Search results for "Carbapenemases"

showing 5 items of 5 documents

Ceftazidime-avibactam use for klebsiella pneumoniae carbapenemase-producing k. pneumoniae infections: A retrospective observational multicenter study

2021

Abstract Background A growing body of observational evidence supports the value of ceftazidime-avibactam (CAZ-AVI) in managing infections caused by carbapenem-resistant Enterobacteriaceae. Methods We retrospectively analyzed observational data on use and outcomes of CAZ-AVI therapy for infections caused by Klebsiella pneumoniae carbapenemase–producing K. pneumoniae (KPC-Kp) strains. Multivariate regression analysis was used to identify variables independently associated with 30-day mortality. Results were adjusted for propensity score for receipt of CAZ-AVI combination regimens versus CAZ-AVI monotherapy. Results The cohort comprised 577 adults with bloodstream infections (n = 391) or nonba…

Microbiology (medical)Adultmedicine.medical_specialtyAzabicyclo CompoundcarbapenemasesBacterial ProteinMicrobial Sensitivity TestsNeutropeniaCeftazidimebeta-Lactamasesbeta-LactamaseCarbapenemasecarbapenemaseBacterial ProteinsRetrospective StudieLower respiratory tract infectionInternal medicineDrug CombinationAnti-Bacterial AgentmedicineHumansKPC-producing Klebsiella pneumoniaeRetrospective StudiesSeptic shockbusiness.industryCeftazidime-avibactamMicrobial Sensitivity Testceftazidime-avibactamMortality rateCarbapenemases; Ceftazidime-avibactam; KPC-producing Klebsiella pneumoniae; Adult; Anti-Bacterial Agents; Azabicyclo Compounds; Bacterial Proteins; Ceftazidime; Drug Combinations; Humans; Microbial Sensitivity Tests; Retrospective Studies; beta-Lactamases; Klebsiella Infections; Klebsiella pneumoniaeKPC-producing Klebsiella pneumoniae; carbapenemases; ceftazidime-avibactammedicine.diseaseCeftazidime/avibactamSettore MED/17KPC-producing Klebsiella pneumoniae; carbapenemases; ceftazidime-avibactam; Adult; Anti-Bacterial Agents; Azabicyclo Compounds; Bacterial Proteins; Ceftazidime; Drug Combinations; Humans; Microbial Sensitivity Tests; Retrospective Studies; beta-Lactamases; Klebsiella Infections; Klebsiella pneumoniaeAnti-Bacterial AgentsKlebsiella InfectionsDrug CombinationsKlebsiella pneumoniaeInfectious DiseasesCohortPropensity score matchingObservational studybusinessAzabicyclo Compoundsmedicine.drugHumanKlebsiella Infection
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Two cases of monomicrobial intraabdominal abscesses due to KPC - 3 Klebsiella pneumoniaeST258 clone

2011

Abstract Background Knowledge of the etiology of pyogenic liver and pancreatic abscesses is an important factor in determining the success of combined surgical and antibiotic treatment. Literature shows geographical variations in the prevalence and distribution of causative organisms, and the spread of Klebsiella pneumoniae carbapenemase-producing bacteria is an emerging cause of abdominal infections. Case presentation We herein describe two cases of intra-abdominal abscesses due to monomicrobial infection by Klebsiella pneumoniae Sequence Type 258 producing K. pneumoniae carbapenemase 3 (KPC-Kp). In case 1, a 50-year-old HIV-negative Italian woman with chronic pancreatitis showed infection…

<it>Klebsiellae pneumoniae</it>medicine.medical_specialtyAbdominal AbscessSettore MED/17 - Malattie Infettivecarbapenemasesmedicine.drug_classKlebsiella pneumoniaeAntibioticsMinocyclineCase ReportDrug resistanceTigecyclineTigecyclinebeta-LactamasesBacterial ProteinsDrug Resistance Multiple BacterialPancreatitis ChronicInternal medicinemedicineHumanslcsh:RC799-869Klebsiellae pneumoniaeSettore MED/12 - GastroenterologiabiologyColistinbusiness.industryAbdominal InfectionLiver NeoplasmsGastroenterologyGeneral MedicineMiddle Agedbiology.organism_classificationmedicine.diseaseAnti-Bacterial AgentsElectrophoresis Gel Pulsed-FieldKlebsiella InfectionsSurgeryPancreatic NeoplasmsSettore MED/18 - Chirurgia GeneraleKlebsiella pneumoniaeColistinPancreatitislcsh:Diseases of the digestive system. Gastroenterologymonomicrobial abscess Klebsiellae pneumoniae carbapenemasesFemalebusinessmonomicrobial abscessmedicine.drugLiver abscessBMC Gastroenterology
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Characterization of Carbapenem-Resistant Enterobacteriaceae Clinical Isolates in Al Thawra University Hospital, Sana'a, Yemen

2020

International audience; Objective: The aim of this study was to investigate the resistance mechanisms of carbapenem-resistant Enterobacteriaceae clinical strains recovered from Al Thawra University Hospital, Sana'a, Yemen. Methods: A total of 27 isolates showing decreased susceptibility to carbapenems were obtained from different clinical specimens in Al Thawra Hospital, Sana'a, Yemen. Strains were identified by Matrix Assisted Laser Desorption Ionization Time-Of-Flight spectroscopy. Susceptibility to antibiotics was determined by the disk diffusion method on Mueller Hinton agar. Carbapenemases-encoding genes, extended-spectrum β-lactamases (ESBLs), and plasmid-mediated quinolone resistance…

MaleYemenKlebsiella pneumoniaeGene ExpressionCarbapenem-resistant enterobacteriaceaeQuinolonesmedicine.disease_causeHospitals Universitychemistry.chemical_compoundChildEscherichia coli InfectionsAged 80 and over0303 health sciencesbiologyEnterobacteriaceae InfectionsMiddle AgedEnterobacteriaceae3. Good healthAnti-Bacterial AgentsBacterial Typing TechniquesMueller-Hinton agarKlebsiella pneumoniae[SDV.MP]Life Sciences [q-bio]/Microbiology and ParasitologyNDM-1-likeChild PreschoolFemalePlasmidsMicrobiology (medical)AdultcarbapenemasesImmunologyMicrobial Sensitivity TestsMicrobiologybeta-Lactam Resistancebeta-LactamasesMicrobiology03 medical and health sciencesEnterobacteriaceaeEnterobacter cloacaemedicineEscherichia coliHumansTypingEscherichia coli030304 developmental biologyAgedPharmacology030306 microbiologyInfantbiochemical phenomena metabolism and nutritionbiology.organism_classificationClone CellsKlebsiella InfectionsCarbapenem-Resistant EnterobacteriaceaechemistryCarbapenemsMultilocus sequence typingbacteriaEnterobacter cloacaeMultilocus Sequence TypingOXA-48-like
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Molecular epidemiology and drug-resistance mechanisms in carbapenem-resistant Klebsiella pneumoniae isolated in patients from a tertiary hospital in …

2020

Abstract Objectives The aim of this study has been to characterize carbapenem-resistant Klebsiella pneumoniae isolates and to determine the resistance mechanisms involved, the clonal relationship between strains and clinical and demographical data of the infected patients. Methods Clinical and demographical data from patients were collected and statistically analysed. Antimicrobial susceptibility testing was performed and resistance genes were detected both phenotypically and genotypically. Conjugation assays were performed to show horizontal transferability of resistance genes. Clonal relationship was also studied. Next-generation sequencing (NGS) was performed to obtain information regard…

0301 basic medicineMicrobiology (medical)Klebsiella pneumoniaeTetracycline030106 microbiologyImmunologyVirulenceDrug resistanceResistance mechanismsMicrobiologyMicrobiologyTertiary Care Centers03 medical and health sciences0302 clinical medicinePlasmidGenotypemedicineImmunology and AllergyHumans030212 general & internal medicineMolecular EpidemiologyMolecular epidemiologybiologybiology.organism_classificationCarbapenemasesQR1-502Klebsiella InfectionsKlebsiella pneumoniaeCarbapenemsPharmaceutical PreparationsSpainMultilocus sequence typingmedicine.drugJournal of Global Antimicrobial Resistance
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Extended-spectrum beta-lactamase-producing and carbapenemase-producing Enterobacter cloacae ventriculitis successfully treated with intraventricular …

2014

SummaryWe present a case of post-neurosurgical ventriculitis caused by carbapenemase-producing Enterobacter cloacae successfully treated with intraventricular colistin. Enterobacter spp are intrinsically resistant to aminopenicillins, cefazolin, and cefoxitin due to the production of constitutive chromosomal AmpC beta-lactamases. Moreover, extended-spectrum beta-lactamase-producing Enterobacter spp have been identified in the USA and Europe, and carbapenems are considered the drug of choice in these cases. Our isolate was sensitive only to fosfomycin, tigecycline, and colistin, and 6 days of intravenous colistin had failed to eradicate the infection. This case provides clinical evidence to …

MaleMicrobiology (medical)Intraventricularmedicine.medical_treatmentTigecyclineFosfomycinCeftazidimebeta-LactamasesCerebral VentriculitisMicrobiologyBacterial ProteinsEnterobacteriaceaeDrug Resistance Multiple BacterialEnterobacter cloacaeVentriculitispolycyclic compoundsVentriculitismedicineHumansMeningitisCefoxitinCarbapenemases Colistin Enterobacter cloacaeAmikacinbiologyColistinbusiness.industryEnterobacteriaceae InfectionsGeneral MedicineEnterobacterbiochemical phenomena metabolism and nutritionCarbapenemasesbacterial infections and mycosesmedicine.diseasebiology.organism_classificationAnti-Bacterial AgentsTreatment OutcomeInfectious DiseasesChild PreschoolBeta-lactamaseColistinbacteriaAdministration Intravenouslipids (amino acids peptides and proteins)TeicoplaninbusinessEnterobacter cloacaemedicine.drugInternational Journal of Infectious Diseases
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