Search results for "Carboxamide"

showing 10 items of 216 documents

Synthesis, antiproliferative activity, and mechanism of action of a series of 2-{[2E]-3-phenylprop-2-enoylamino}benzamides

2011

Several new 2-{[(2E)-3-phenylprop-2-enoyl]amino}benzamides 12a–s and 17t–v were synthesized by stirring in pyridine the (E)-3-(2-R1-3-R2-4-R3-phenyl)acrylic acid chlorides 11c–k and 11t–v with the appropriate anthranilamide derivatives 10a–c or the 5-iodoanthranilic acid 13. Some of the synthesized compounds were evaluated for their in vitro antiproliferative activity against the full NCI tumor cell line panel derived from nine clinically isolated cancer types (leukemia, non-small cell lung, colon, CNS, melanoma, ovarian, renal, prostate and breast). COMPARE analysis, effects on tubulin polymerization in cells and with purified tubulin, and effects on cell cycle distribution for 17t, the mo…

Pyridinesmedicine.drug_classStereochemistryAntineoplastic AgentsCarboxamideChemical synthesisArticlePolymerizationInhibitory Concentration 50Structure-Activity RelationshipTubulinCell Line TumorDrug DiscoverymedicineHumansStructure–activity relationshiportho-AminobenzoatesCytotoxicity2-{[2E]-3-phenylprop-2-enoylamino}benzamides antimitotic agents cytotoxic activityPharmacologyDose-Response Relationship DrugbiologyChemistryTubulin ModulatorsCell CycleOrganic ChemistryGeneral MedicineCell cycleSettore CHIM/08 - Chimica FarmaceuticaTubulin ModulatorsTubulinAcrylatesMechanism of actionBiochemistryBenzamidesbiology.proteinDrug Screening Assays Antitumormedicine.symptom
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Fluoreszierende silane als OH-selektive schutzgruppen

1985

Abstract Fluorescent tertiary silanes are synthesized which, under cesium fluoride/ imidazole activation, discriminate between primary and secondary OH groups. Serine n-butylamide reacts with [5-dimethylamino(1-naphthyl)]dimethylsilane ( 1 ) and diisopropyl[5-dimethylamino(1-naphthyl)]silane ( 2 ) to form the silyl ethers (−)- l -3-[5-dimethylamino(1-naphthyl)]-dimethylsilyloxy]serine n-butylamid ( 14 ) and (−)- l -3-[diisopropyl[5-dimethylamino(1-naphthyl)]silyloxy]serine n-butylamid ( 15 ) exclusively. The silyl ethers are cleaved on treatment with H 2 F 2 , forming the corresponding fluorescent silyl fluorides. Absorption and fluorescence data as well as stability data for the hydrolysis…

SilanesDimethylsilaneSilylationChemistrymedicine.drug_classStereochemistryOrganic ChemistryCarboxamideBiochemistryMedicinal chemistryInorganic Chemistrychemistry.chemical_compoundpolycyclic compoundsMaterials ChemistrymedicineImidazolePhysical and Theoretical ChemistryProtecting groupAliphatic compoundFluorideJournal of Organometallic Chemistry
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CCDC 245908: Experimental Crystal Structure Determination

2006

Related Article: R.Frohlich, T.C.Rosen, O.G.J.Meyer, K.Rissanen, G.Haufe|2006|J.Mol.Struct.|787|50|doi:10.1016/j.molstruc.2005.10.033

Space GroupCrystallography(1R2S)-(-)-2-Fluoro-2-phenylcyclopropanecarboxamideCrystal SystemCrystal StructureCell ParametersExperimental 3D Coordinates
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CCDC 1521297: Experimental Crystal Structure Determination

2017

Related Article: Marlena Łukomska-Rogala, Agnieszka J. Rybarczyk-Pirek, Krzysztof Ejsmont, Marcin Jasiński, Marcin Palusiak|2017|Struct.Chem.|28|1229|doi:10.1007/s11224-017-0935-x

Space GroupCrystallography15-dimethyl-3-oxo-N-(4-(trifluoromethyl)phenyl)-1H-imidazole-4-carboxamideCrystal SystemCrystal StructureCell ParametersExperimental 3D Coordinates
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CCDC 1521295: Experimental Crystal Structure Determination

2017

Related Article: Marlena Łukomska-Rogala, Agnieszka J. Rybarczyk-Pirek, Krzysztof Ejsmont, Marcin Jasiński, Marcin Palusiak|2017|Struct.Chem.|28|1229|doi:10.1007/s11224-017-0935-x

Space GroupCrystallography15-dimethyl-3-oxo-N-phenyl-1H-imidazole-4-carboxamide hydrateCrystal SystemCrystal StructureCell ParametersExperimental 3D Coordinates
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CCDC 1536511: Experimental Crystal Structure Determination

2017

Related Article: Santiago Matías Ruatta, Marcelo César Murguía, Carmen Ramírez de Arellano, Santos Fustero|2017|Tetrahedron Lett.|58|2441|doi:10.1016/j.tetlet.2017.05.029

Space GroupCrystallography1-t-butyl-5-(furan-2-yl)-N-(4-nitrophenyl)-1H-pyrazole-3-carboxamideCrystal SystemCrystal StructureCell ParametersExperimental 3D Coordinates
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CCDC 133179: Experimental Crystal Structure Determination

2003

Related Article: M.Albrecht, K.Witt, E.Wegelius, K.Rissanen|2000|Tetrahedron|56|591|doi:10.1016/S0040-4020(99)01057-1

Space GroupCrystallography2-(N-n-Hexylcarboxamide)-8-hydroxyquinolineCrystal SystemCrystal StructureCell ParametersExperimental 3D Coordinates
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CCDC 280351: Experimental Crystal Structure Determination

2006

Related Article: R.Frohlich, T.C.Rosen, O.G.J.Meyer, K.Rissanen, G.Haufe|2006|J.Mol.Struct.|787|50|doi:10.1016/j.molstruc.2005.10.033

Space GroupCrystallographyCrystal System(+-)-cis-2-Fluoro-2-phenylcyclopropanecarboxamideCrystal StructureCell ParametersExperimental 3D Coordinates
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CCDC 280350: Experimental Crystal Structure Determination

2006

Related Article: R.Frohlich, T.C.Rosen, O.G.J.Meyer, K.Rissanen, G.Haufe|2006|J.Mol.Struct.|787|50|doi:10.1016/j.molstruc.2005.10.033

Space GroupCrystallographyCrystal System(+-)-trans-2-Fluoro-2-phenylcyclopropanecarboxamideCrystal StructureCell ParametersExperimental 3D Coordinates
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CCDC 1521298: Experimental Crystal Structure Determination

2017

Related Article: Marlena Łukomska-Rogala, Agnieszka J. Rybarczyk-Pirek, Krzysztof Ejsmont, Marcin Jasiński, Marcin Palusiak|2017|Struct.Chem.|28|1229|doi:10.1007/s11224-017-0935-x

Space GroupCrystallographyCrystal System3-hydroxy-15-dimethyl-N-(4-nitrophenyl)-1H-imidazole-4-carboxamideCrystal StructureCell ParametersExperimental 3D Coordinates
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