Search results for "Carcinoma in Situ"

showing 10 items of 48 documents

Segmental resection of distal ureter with termino-terminal ureteric anastomosis vs bladder cuff removal and ureteric re-implantation for upper tract …

2019

OBJECTIVES: To compare overall (OS), cancer-specific (CSS), recurrence free survival (RFS) and post-operative renal function among patients affected by upper tract urothelial carcinoma (UTUC) of the distal (lower lumbar and pelvic) ureter, electively treated with segmental resection and termino-terminal anastomosis (TT) vs bladder cuff removal and ureteral re-implantation (RR). PATIENTS AND METHODS: A multicentre retrospective study, including 84 patients diagnosed with UTUC of the distal ureter and treated with TT or RR, is presented. The primary endpoint was to compare TT and RR in terms of OS, CSS and RFS. As a secondary outcome we compared the post-operative creatinine values as an inde…

Male030232 urology & nephrologysegmental ureterectomySettore MED/24 - Urologiachemistry.chemical_compound0302 clinical medicine#utuc; renal function; segmental ureterectomy; survival; termino-terminal ureteroureterostomy; upper tract urothelial carcinoma; ureteric re-implantationAnastomosis Surgicaltermino-terminal ureteroureterostomyMiddle Agedupper tract urothelial carcinomaTreatment Outcomemedicine.anatomical_structureItalyCreatinineReplantation030220 oncology & carcinogenesis#utucCuffUreteral reimplantationFemaleSegmental resectionCarcinoma in Situmedicine.medical_specialtyUrologyUrinary BladderUrologyRenal functionAnastomosissurvivalDisease-Free Survival03 medical and health sciencesUreterLumbarBiomarkers TumormedicineHumansRetrospective StudiesCreatinineUreteral Neoplasmsbusiness.industryrenal functionRenal function; Segmental ureterectomy; Survival; Termino-terminal ureteroureterostomy; Upper tract urothelial carcinoma; Ureteral reimplantationRetrospective cohort studychemistryUreterbusinessureteric re-implantationutuc
researchProduct

Human endogenous retrovirus rec interferes with germ cell development in mice and may cause carcinoma in situ, the predecessor lesion of germ cell tu…

2005

Germ cell tumors (GCTs) are among the most common malignancies in young men. We have previously documented that patients with GCT frequently produce serum antibodies directed against proteins encoded by human endogenous retrovirus (HERV) type K sequences. Transcripts originating from the env gene of HERV-K, including the rec-relative of human immunodeficiency virus rev, are highly expressed in GCTs. We report here that mice that inducibly express HERV-K rec show a disturbed germ cell development and may exhibit, by 19 months of age, changes reminiscent of carcinoma in situ, the predecessor lesion of classic seminoma in humans. This provides the first direct evidence that the expression of a…

MaleCancer ResearchTime FactorsvirusesTransgeneBlotting WesternEndogenous retrovirusApoptosisMice TransgenicEndogenyBiologymedicine.disease_causeMiceViral Envelope ProteinsCell Line TumorGeneticsmedicineAnimalsHumansHuman endogenous retrovirus KRNA MessengerMolecular BiologyModels GeneticReverse Transcriptase Polymerase Chain ReactionEndogenous RetrovirusesSeminomaNeoplasms Germ Cell and EmbryonalSeminiferous Tubulesmedicine.diseaseVirologyProtein Structure TertiaryAlternative SplicingGerm Cellsmedicine.anatomical_structureMicroscopy FluorescenceCancer researchGerminomaGerm cell tumorsCarcinogenesisCarcinoma in SituGerm cellOncogene
researchProduct

Randomized controlled single‐blinded clinical trial of functional voice outcome after vascular targeting KTP laser microsurgery of early laryngeal ca…

2019

Abstract Background Local control rate (LCR) of early glottic cancer is high after radiation therapy or transoral laser microsurgery (TLM). The aim of this study was to investigate functional voice outcome after TLM using a microvessel‐ablative potassium‐titanyl‐phosphate (KTP) laser in comparison with a gold standard cutting CO2 laser. Methods The primary end point of this prospective, randomized, single‐blinded, clinical phase II study with control group was voice outcome during a follow‐up of 6 months assayed by Voice Handicap Index (VHI‐30)‐questionnaires in patients with unilateral high‐grade dysplasia, carcinoma in situ or early glottic cancer undergoing TLM‐KTP (n = 8) or TLM‐CO2 (n …

MaleMicrosurgeryTime Factorsmedicine.medical_treatmentLasers Solid-State0302 clinical medicineClinical endpointSingle-Blind MethodProspective StudiesTransoral laser microsurgery030223 otorhinolaryngologyEarly Detection of CancerAged 80 and overMiddle AgedTreatment Outcome030220 oncology & carcinogenesisCarcinoma Squamous CellOriginal ArticleFemaleLaser Therapymedicine.medical_specialtyCO2 laserVoice QualityT1 glottic cancerVoice Handicap Index (VHI‐30)Statistics Nonparametric03 medical and health scienceslocal control ratemedicineHumansNeoplasm InvasivenessVoice Handicap IndexLaryngeal NeoplasmsAgedNeoplasm Stagingbusiness.industryCarcinoma in situReproducibility of ResultsCancerOriginal ArticlesRecovery of Functionmedicine.diseaseSurgeryClinical trialRadiation therapyangiolytic therapyOtorhinolaryngologyDysplasiaLasers GasbusinessFollow-Up StudiesHead & Neck
researchProduct

Multiple Mucosal Biopsies and Postoperative Urinary Cytology in Patients with Bladder Cancer

1990

Seventy-one patients with bladder tumors of stage Ta, T1 or T2 were studied by bladder mucosal biopsies. In 34 (48%) patients abnormal histology was found in at least one of the biopsies. The occurrence and severity of mucosal abnormalities were related to tumor grade and stage. Urinary cytology after complete tumor resection was positive in 18 of 19 patients with abnormal biopsies and in 6 of 12 patients with normal biopsies. Postoperative urinary cytology seems to be a good indicator for the presence of urothelial atypia.

MalePathologymedicine.medical_specialtyBiopsyUrologyUrinary systemUrinary BladderUrologyCytologyBiopsyAtypiamedicineHumansCarcinoma Transitional CellMucous MembraneUrinary bladderBladder cancermedicine.diagnostic_testbusiness.industryCarcinoma in situMiddle Agedmedicine.diseaseNeck of urinary bladdermedicine.anatomical_structureUrinary Bladder NeoplasmsFemalebusinessCarcinoma in SituEuropean Urology
researchProduct

Effect on postoperative survival of the status of distal ureteral margin: The necessity to achieve negative margins at the time of radical cystectomy.

2015

Background: Despite several studies, the adequate management of positive distal ureter margins at the time of radical cystectomy (RC) remains controversial. Particularly, it is not clear whether the achievement of negative distal ureter margins at the intraoperative frozen sections (IFS) affects postoperative cancer-specific mortality (CSM). Methods: In all, 1,447 consecutive patients treated with RC at a single center between January 1987 and August 2014 were considered. Multivariable (MVA) logistic regression analyses were used to determine predictors of positive IFS. MVA Cox regression analyses were used to test the effect on CSM of intraoperative conversion to negative margins. Results:…

Malemedicine.medical_specialtyFrozen sectionUrologymedicine.medical_treatment030232 urology & nephrologySingle CenterCystectomySettore MED/24 - UrologiaUreteral marginCystectomy03 medical and health sciences0302 clinical medicineRetrospective StudiemedicineHumansPostoperative PeriodUreteral neoplasmSurvival analysisMarginAgedRetrospective StudiesBladder cancerbusiness.industryProportional hazards modelUreteral NeoplasmsCarcinoma in situBladder cancerOdds ratioUreteral NeoplasmMiddle Agedmedicine.diseaseSurvival AnalysisSurgeryRadical cystectomyOncology030220 oncology & carcinogenesisFemaleSurvival AnalysibusinessHumanUrologic oncology
researchProduct

Conclusions from the histological diagnosis of low-grade intraepithelial neoplasia in Barrett's oesophagus.

2007

It is well known that low-grade intraepithelial neoplasia (LGIN) in Barrett's oesophagus (BE) might progress to high-grade intraepithelial neoplasia (HGIN) or carcinoma. Since accurate diagnosis of LGIN is difficult, general pathologists are frequently uncertain about the diagnosis of LGIN and its follow-up risks. The purpose of this study was to analyse the divergence between the diagnoses of general and specialized gastrointestinal pathologists.Fifty consecutive patients with a previous diagnosis of LGIN in BE, made by a general pathologist, were included in our study. The histopathological slides of every patient were reassessed in a blinded fashion by two specialized gastrointestinal (G…

Malemedicine.medical_specialtyGastroenterologyBarrett EsophagusInternal medicineMetaplasiamedicineCarcinomaHumansMedical diagnosisLow Grade Intraepithelial NeoplasiaAgedIntraepithelial neoplasiamedicine.diagnostic_testEsophageal diseasebusiness.industryGastroenterologyMiddle Agedmedicine.diseasedigestive system diseasesEndoscopysurgical procedures operativeHistopathologyFemalemedicine.symptombusinessCarcinoma in SituFollow-Up StudiesScandinavian journal of gastroenterology
researchProduct

Chemotherapy for Urinary Bladder Cancer: Developments, Trends, and Future Perspectives

1982

The role of chemotherapy in the management of transitional bladder tumors can conveniently be considered under two principal headings — topical (intracavitary) and sytemic chemotherapy, as the indications for these modalities are distinctly different. The intent of topical administration of cytoxic agents may be (1) prophylactic to prevent recurrences or new occurrences after TUR; (2) curative to clear the bladder of extensive non-resectable multifocal disease, or to control carcinoma in situ.

OncologyChemotherapymedicine.medical_specialtyUrinary bladderBladder cancerUrinary Bladder Cancerbusiness.industrymedicine.medical_treatmentCarcinoma in situmedicine.diseasemedicine.anatomical_structureMultifocal diseaseInternal medicineBladder tumorSuperficial bladder cancerMedicinebusiness
researchProduct

Prognostic factors and risk groups in T1G3 non-muscle-invasive bladder cancer patients initially treated with Bacillus Calmette-Guérin: results of a …

2014

Contains fulltext : 153742.pdf (Publisher’s version ) (Closed access) BACKGROUND: The impact of prognostic factors in T1G3 non-muscle-invasive bladder cancer (BCa) patients is critical for proper treatment decision making. OBJECTIVE: To assess prognostic factors in patients who received bacillus Calmette-Guerin (BCG) as initial intravesical treatment of T1G3 tumors and to identify a subgroup of high-risk patients who should be considered for more aggressive treatment. DESIGN, SETTING, AND PARTICIPANTS: Individual patient data were collected for 2451 T1G3 patients from 23 centers who received BCG between 1990 and 2011. OUTCOME MEASUREMENTS AND STATISTICAL ANALYSIS: Using Cox multivariable re…

OncologyMaleNon–muscle-invasive bladderBacillus Calmette-Guerin; BCG; Non-muscle-invasive bladder cancer; Prognostic factors; T1G3Settore MED/24 - UrologiaRisk groupsRetrospective StudieRisk FactorsBCGAge Factorskin and connective tissue diseasesBacillus Calmette-GuerinBacillus (shape)Prognostic factorbiologyBacillus Calmette-Gue´rin BCG Non–muscle-invasive bladder cancer Prognostic factors T1G3Age FactorsBacillus Calmette-Gue´rinMiddle AgedPrognosisTumor BurdenBacilluSurvival RateUrological cancers Radboud Institute for Health Sciences [Radboudumc 15]Urinary Bladder NeoplasmBCG VaccineDisease ProgressionFemaleNon muscle invasiveCalmette-GuérinCarcinoma in SituHumanmedicine.medical_specialtyPrognosiNon-muscle-invasive bladder cancerUrologyUrologyT1G3Prognostic factorsCystectomyRisk AssessmentNon–muscle-invasive bladder cancerFollow-Up StudieAdjuvants ImmunologicInternal medicineUrological cancers Radboud Institute for Molecular Life Sciences [Radboudumc 15]medicinecancerHumansAgedRetrospective StudiesBladder cancerbusiness.industryRisk Factorbiology.organism_classificationmedicine.diseaseMulticenter studyUrinary Bladder NeoplasmsProper treatmentNeoplasm Recurrence LocalbusinessFollow-Up StudiesEuropean urology
researchProduct

Chemotherapy of bladder tumours.

1978

OncologyNephrologymedicine.medical_specialtyChemotherapyBladder cancerPapillomabusiness.industryUrologymedicine.medical_treatmentBLADDER PAPILLOMAAntineoplastic Agentsmedicine.diseaseTopical chemotherapyCarcinoma PapillaryUrinary Bladder NeoplasmsRecurrenceInternal medicineChemoprophylaxisMedicineHumansNeoplasm MetastasisbusinessCarcinoma in SituThiotepaTeniposideUrological research
researchProduct

Vulvar cancer: a review for dermatologists.

2015

Vulvar malignancies are important tumors of the female reproductive system. They represent a serious health issue with an incidence between 2 and 7 per 100,000 and year. We provide a review about most important cancer entities, i.e., melanoma, squamous cell carcinoma, basal cell carcinoma, neuroendocrine cancer, and skin adnexal malignancies. Squamous cell carcinoma is the most common vulvar malignancy that can develop from vulvar intraepithelial neoplasia or de novo. Basal cell carcinoma represents only 2 % of all vulvar cancers. Melanoma of the vulva exists in two major types—superficial spreading and acral lentiginous. A special feature is the occurrence of multiple vulvar melanomas. Of …

Oncologymedicine.medical_specialtySkin NeoplasmsMalignancyVulvaVulvaDiagnosis DifferentialVulva · Squamous cell carcinoma · Basal cell carcinoma · Melanoma · Paget’s disease · Adnexal carcinomasInternal medicineCarcinomamedicineSettore MED/35 - Malattie Cutanee E VenereeHumansBasal cell carcinomaMelanomaNeoplasm StagingSkinintegumentary systemVulvar Neoplasmsurogenital systembusiness.industryMelanomaCancerGeneral MedicineVulvar cancermedicine.diseaseVulvar intraepithelial neoplasiaPrognosisDermatologyfemale genital diseases and pregnancy complicationsNeuroendocrine Tumorsmedicine.anatomical_structurePaget Disease ExtramammaryCarcinoma Basal CellCarcinoma Squamous CellFemaleNeoplasms Adnexal and Skin AppendagebusinessCarcinoma in SituWiener medizinische Wochenschrift (1946)
researchProduct