Search results for "Cardiac"

Beta-3 adrenergic receptor overexpression reverses aortic stenosis-induced heart failure and restores balanced mitochondrial dynamics

2022

25 p.-7 fig.

Electrocardiographic Abnormalities and Mortality in Epilepsy Patients

2021

Background and Objectives: People with epilepsy (PWE) have a 2–3 times higher mortality rate than the general population. Sudden unexpected death in epilepsy (SUDEP) comprises a significant proportion of premature deaths, whereas sudden cardiac death (SCD) is among the leading causes of sudden death in the general population. Cardiac pathologies are significantly more prevalent in PWE. Whether electrocardiographic (ECG) parameters are associated with remote death in PWE has yet to be elucidated. The study objective was to assess whether interictal ECG parameters are associated with mortality in the long-term. Materials and Methods: The study involved 471 epilepsy patients who were hospitali…

Management of Direct Oral Anticoagulants in Patients with Atrial Fibrillation Undergoing Cardioversion

2019

Atrial fibrillation the most common cardiac arrhythmia. Its incidence rises steadily with each decade, becoming a real “epidemic phenomenon”. Cardioversion is defined as a rhythm control strategy which, if successful, restores normal sinus rhythm. This, whether obtained with synchronized shock or with drugs, involves a periprocedural risk of stroke and systemic embolism which is reduced by adequate anticoagulant therapy in the weeks before or by the exclusion of left atrial thrombi. Direct oral anticoagulants are safe, manageable, and provide rapid onset of oral anticoagulation; they are an important alternative to heparin/warfarin from all points of view, with a considerable reduction in b…

Variations in physiological responses to thermal stress in congeneric limpets in the Mediterranean Sea

2014

Cardiac activity (Arrhenius breakpoint temperatures and Q10 relationships) and heat shock response (hsp70 expression) were measured in the congeneric limpets Patella rustica, P. caerulea and P. ulyssiponensis in order to test the relationship between their vertical distribution and physiological thermal tolerance. These species exhibit different vertical distributions along Mediterranean shores and despite the narrow tidal range in the Mediterranean, they experience different environmental conditions and consequently had specific thermal windows. Cardiac activity of the upper zoned P. rustica was maintained at higher temperatures than its mid- or low shore counterparts, P. caerulea and P. u…

TRPA1 channel is a cardiac target of mIGF-1/SIRT1 signaling.

2014

Cardiac overexpression of locally acting muscle-restricted (m)IGF-1 and the consequent downstream activation of NAD+-dependent protein deacetylase sirtuin 1 (SIRT1) trigger potent cardiac antioxidative and antihypertrophic effects. Transient receptor potential (TRP) cation channel A1 (TRPA1) belongs to the TRP ion channel family of molecular detectors of thermal and chemical stimuli that activate sensory neurons to produce pain. Recently, it has been shown that TRPA1 activity influences blood pressure, but the significance of TRPA1 in the cardiovascular system remains elusive. In the present work, using genomic screening in mouse hearts, we found that TRPA1 is a target of mIGF-1/SIRT1 sign…

Integration of different cardiac electrophysiological models into a single simulation pipeline

2012

Clinical translation of computational models of the heart has been hampered by the absence of complete and rigorous technical and clinical validation, as well as benchmarking of the developed tools. To address this issue, a dataset containing the cardiac anatomy and fibre orientations from magnetic resonance images (MRI), as well as epicardial transmembrane potentials from optical mapping acquired on ex-vivo porcine hearts, have previously been made available to the community. Image processing techniques were developed to integrate MRI images with electrical information. Different models were tested and compared with the integrated data1, including: i) a new methodology to customize and reg…

Über das Membranpotential am Vorhof des Meerschweinchenherzens nach Hypothermie / The Membrane Potential of the Cardiac Atrium of Guinea Pigs after H…

1969

Linke Vorhofe von Meerschweinchenherzen wurden prapariert und 30 min in Tyrodelosung mit 5, 4m MK+ /l bei 35° C aquilibriert. Anschliesend wurden die Praparate 90 min bei 4–6° C von einer Tyrodelosung mit 1,35mMK+ /l umspult. Danach wurden die Vorhofe in einer Tyrodelosung mit 21,6 mM K+ /1 bei 35° C rasch wiedererwarmt.

Lipomatous Metaplasia. Two Chronic Infarcts in the Same Patient Detected by Cardiac Magnetic Resonance

2009

microRNAs and cardiac progenitor cells

2012

Matrix Metalloproteinases (MMPs), Their Genetic Variants and miRNA in Mitral Valve Diseases: Potential Biomarker Tools and Targets for Personalized T…

2016

Mitral valve diseases (MVD)s, comprising congenital and acquired forms, are characterized by a diverse etiology, pathophysiology, prevalence, and incidence. In industrialized countries, the acquired forms represent 2.5% of all cardiovascular diseases, with a marked augmentation after the age of 65 years. In addition, all forms of MVDs (i.e., degenerative forms) have a difficult clinical management. The major challenge is 'the early diagnosis', and echocardiographic analysis has been shown inappropriate for diagnosing MVD in moderate forms. Thus, there is a strong need to identify more appropriate biomarker tools to diagnose MVDs at early clinical stage before complications occur and worsen …