Search results for "Cardiovascular diseases"

showing 10 items of 2174 documents

Large-scale association analysis identifies new risk loci for coronary artery disease

2016

Coronary artery disease (CAD) is the commonest cause of death. Here, we report an association analysis in 63,746 CAD cases and 130,681 controls identifying 15 loci reaching genome-wide significance, taking the number of susceptibility loci for CAD to 46, and a further 104 independent variants (r 2 < 0.2) strongly associated with CAD at a 5% false discovery rate (FDR). Together, these variants explain approximately 10.6% of CAD heritability. Of the 46 genome-wide significant lead SNPs, 12 show a significant association with a lipid trait, and 5 show a significant association with blood pressure, but none is significantly associated with diabetes. Network analysis with 233 candidate genes …

AdultAsian Continental Ancestry GroupMaleCandidate geneBIO/12 - BIOCHIMICA CLINICA E BIOLOGIA MOLECOLARE CLINICAPopulationEuropean Continental Ancestry GroupQuantitative Trait LociCADGenome-wide association studySingle-nucleotide polymorphismCoronary Artery Disease030204 cardiovascular system & hematologyBiologyQuantitative trait locusBioinformaticsPolymorphism Single NucleotideArticleWhite Peoplecoronary artery disease risk lociCell LineCoronary artery disease03 medical and health sciences0302 clinical medicineAsian PeopleRisk FactorsmedicineHumansgeneticsGene Regulatory NetworksGenetic Predisposition to Diseasecardiovascular diseasesPolymorphismeducation030304 developmental biologyGenetic associationAgedGenetics0303 health scienceseducation.field_of_studyAdult Aged Asian Continental Ancestry Group Cell Line Coronary Artery Disease; genetics European Continental Ancestry Group; genetics Female Gene Regulatory Networks Genetic Predisposition to Disease Genome-Wide Association Study Humans Male Middle Aged Polymorphism; Single Nucleotide Quantitative Trait Loci Risk FactorsSingle NucleotideMiddle Agedmedicine.disease3. Good healthFemaleGenome-Wide Association StudyNature Genetics
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Changes in body composition, physical performance and cardiovascular risk factors after a 3-week integrated body weight reduction program and after 1…

2005

To investigate the short- and medium-term (ie, at 1-y follow-up) effects of a hospital-based body weight reduction (BWR) program lasting 3 weeks in severely obese individuals.Longitudinal, clinical intervention study entailing energy-restricted diet, tailored aerobic-strength exercise, psychological counselling and nutritional education during a 3-week period followed by 49 weeks of indirect supervision at home.In all, 45 women and 19 men aged 30.2 +/- 7.2 y (mean +/- s.d.) with severe obesity (BMI: 41.3 +/- 4.3 kg/m(2)), classified as weight losers (finalinitial weight) and regainers (finalor =initial weight).Body composition, physical performance and cardiovascular risk factors before and…

AdultBlood GlucoseCounselingMalemedicine.medical_specialtyTime FactorsNutritional SciencesMedicine (miscellaneous)Physical exerciseSex FactorsRisk FactorsInternal medicineWeight LossmedicineHumansLongitudinal StudiesObesityExercise physiologyRisk factorDiet Fat-RestrictedExerciseNutrition and Dieteticsmedicine.diagnostic_testbusiness.industrymedicine.diseaseObesityPhysical activity levelEndocrinologyBlood pressureCholesterolItalyCardiovascular DiseasesPhysical FitnessLean body massBody CompositionPhysical EnduranceFemalebusinessLipid profileFollow-Up StudiesProgram EvaluationEuropean journal of clinical nutrition
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Rheological blood behavior is not only influenced by cardiovascular risk factors but also by aging itself. Research into 927 healthy Spanish Mediterr…

2013

It is not well-established whether the alterations that the hemorheological profile undergoes with aging are an effect of concomitant cardiovascular risk factors or are due to age itself. To clarify this issue, we investigated the effect of age on blood rheology in a population of 927 healthy subjects from eastern Spain aged between 16-85 years, divided into four age groups (<30, 30-44, 45-50, ≥60 years) with and without cardiovascular risk factors. We determined blood viscosity, corrected blood viscosity (BVc), plasma viscosity (PV), erythrocyte aggregation (EA), erythrocyte deformability (EEI60) and fibrinogen, along with glucose and plasma lipids. We found that corrected blood viscosity …

AdultBlood GlucoseErythrocyte AggregationMalemedicine.medical_specialtyAgingAdolescentPhysiologyBlood viscosityPopulationFibrinogenLogistic regressionErythrocyte aggregationYoung AdultRisk FactorsPhysiology (medical)Internal medicineMedicineErythrocyte deformabilityHumanseducationMean corpuscular volumeAgedAged 80 and overeducation.field_of_studymedicine.diagnostic_testbusiness.industryAge FactorsFibrinogenHematologyMiddle AgedLipidsEndocrinologyCardiovascular DiseasesSpainConcomitantImmunologyHemorheologyFemaleCardiology and Cardiovascular Medicinebusinessmedicine.drugClinical hemorheology and microcirculation
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Increased thioredoxin levels are related to insulin resistance in familial combined hyperlipidaemia

2015

BACKGROUND Thioredoxins (TRX) are major cellular protein disulphide reductases that are critical for redox regulation. Oxidative stress and inflammation play promoting roles in the genesis and progression of atherosclerosis, but until now scarce data are available considering the influence of TRX activity in familial combined hyperlipidaemia (FCH). Since FCH is associated with high risk of cardiovascular disease, the objective of the present study was to assess oxidative stress status in FCH patients, and evaluate the influence of insulin resistance (IR). MATERIALS AND METHODS A cohort of 35 control subjects and 35 non-related FCH patients were included, all of them nondiabetic, normotensiv…

AdultBlood GlucoseMale0301 basic medicinemedicine.medical_specialtyanimal structuresmedicine.medical_treatmentClinical BiochemistryHyperlipidemia Familial Combined030204 cardiovascular system & hematologymedicine.disease_causeBiochemistry03 medical and health scienceschemistry.chemical_compoundThioredoxins0302 clinical medicineInsulin resistanceInternal medicinemedicineHumansTriglyceridesGlutathione Disulfidemedicine.diagnostic_testbusiness.industryInsulinCholesterol HDLCase-control studyCholesterol LDLGeneral MedicineGlutathioneMiddle Agedmedicine.diseaseGlutathioneOxidative Stress030104 developmental biologyEndocrinologychemistryCardiovascular DiseasesCase-Control StudiesGlutathione disulfideFemaleInsulin ResistanceThioredoxinLipid profilebusinessOxidative stressEuropean Journal of Clinical Investigation
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Sleep apnoea severity independently predicts glycaemic health in nondiabetic subjects: the ESADA study

2014

Abstract: Obstructive sleep apnoea (OSA) is associated with increased risk of dysglycaemia but the intimate link of these conditions with obesity makes discerning an independent relationship between them challenging. Glycosylated haemoglobin (HbA1c) levels predict adverse cardiovascular outcomes in nondiabetics but there is a lack of population-level data exploring the relationship of HbA1c with OSA. A cross-sectional analysis of 5294 participants in the multinational European Sleep Apnoea Cohort (European Sleep Apnoea Database) study was performed, assessing the relationship of OSA severity with HbA1c levels in nondiabetic subjects, with adjustment for confounding factors. HbA1c levels cor…

AdultBlood GlucoseMalePulmonary and Respiratory Medicinemedicine.medical_specialtyAdolescentCross-sectional studyPolysomnographyintermittent hypoxia insulin resistance diabetes obesityBlood PressurePolysomnographySettore MED/10 - Malattie Dell'Apparato Respiratoriota3111Young Adultstomatognathic systemInternal medicineDiabetes MellitusmedicineHumansProspective StudiesSleep studyHypoxiaAgedAged 80 and overGlycated HemoglobinSleep Apnea ObstructiveAnthropometrymedicine.diagnostic_testbusiness.industryConfoundingSleep apneaOdds ratioMiddle Agedmedicine.diseasenervous system diseasesrespiratory tract diseasesEuropeCross-Sectional StudiesTreatment OutcomeQuartileCardiovascular DiseasesHyperglycemiaMultivariate AnalysisCohortPhysical therapyFemaleHuman medicinebusinessEuropean Respiratory Journal
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Pasta consumption and connected dietary habits: Associations with glucose control, adiposity measures, and cardiovascular risk factors in people with…

2019

Background: Pasta is a refined carbohydrate with a low glycemic index. Whether pasta shares the metabolic advantages of other low glycemic index foods has not really been investigated. The aim of this study is to document, in people with type-2 diabetes, the consumption of pasta, the connected dietary habits, and the association with glucose control, measures of adiposity, and major cardiovascular risk factors. Methods: We studied 2562 participants. The dietary habits were assessed with the European Prospective Investigation into Cancer and Nutrition (EPIC) questionnaire. Sex-specific quartiles of pasta consumption were created in order to explore the study aims. Results: A higher pasta con…

AdultBlood GlucoseMalecardiovascular risk factorsAdolescentSaturated fatlcsh:TX341-641Type 2 diabetesAdded sugarDietary habitCardiovascular risk factorArticleSettore MED/13 - EndocrinologiaYoung AdultEnvironmental healthDiabetes mellitusGlucose controlmedicinebody mass index; cardiovascular risk factors; dietary habits; glucose control; pasta consumption; type 2 diabetesDietary CarbohydratesHumansHypoglycemic AgentsChilddietary habitsBody mass indexAdiposityAgedNutrition and Dieteticsbusiness.industryPasta consumptionConfoundingfood and beveragesType 2 diabetesFeeding BehaviorMiddle Agedmedicine.diseaseObesityEuropean Prospective Investigation into Cancer and NutritionDiabetes Mellitus Type 2ItalyCardiovascular DiseasesChild PreschoolFemalebusinessBody mass indexlcsh:Nutrition. Foods and food supplyFood Science
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Clinical profiles and quality of care of subjects with type 2 diabetes according to their cardiovascular risk: an observational, retrospective study

2021

Abstract Background The European Society of Cardiology (ESC) recently defined cardiovascular risk classes for subjects with diabetes. Aim of this study was to explore the distribution of subjects with type 2 diabetes (T2D) by cardiovascular risk groups according to the ESC classification and to describe the quality indicators of care, with particular regard to cardiovascular risk factors. Methods The study is based on data extracted from electronic medical records of patients treated at the 258 Italian diabetes centers participating in the AMD Annals initiative. Patients with T2D were stratified by cardiovascular risk. General descriptive indicators, measures of intermediate outcomes, inten…

AdultBlood GlucoseMalelcsh:Diseases of the circulatory (Cardiovascular) systemmedicine.medical_specialtyTime FactorsEndocrinology Diabetes and MetabolismType 2 diabetesIncretinsRisk AssessmentDiabetes mellitusInternal medicinemedicineElectronic Health RecordsHumansHypoglycemic AgentsMedical prescriptionSodium-Glucose Transporter 2 InhibitorsOriginal InvestigationAgedQuality Indicators Health CareRetrospective StudiesAngiologyCardiovascular risk Humans Hypoglycemic Agents Incretins Italy Male Middle Aged Retrospective Studies Risk Assessment Sodium-Glucose Transporter 2 Inhibitors Time Factors Treatment Outcome Quality Indicators Health Care Quality of care Type 2 diabetes Adult Aged Aged 80 and over Biomarkers Blood Glucose Cardiovascular Diseases Diabetes Mellitus Type 2 Dipeptidyl-Peptidase IV Inhibitors Heart Disease Risk Factors Female Electronic Health RecordsAged 80 and overDipeptidyl-Peptidase IV Inhibitorsbusiness.industryMedical recordQuality of careType 2 diabetesRetrospective cohort studyMiddle AgedCardiovascular riskmedicine.diseaseTreatment OutcomeDiabetes Mellitus Type 2ItalyCardiovascular DiseasesHeart Disease Risk Factorslcsh:RC666-701AlbuminuriaFemaleObservational studymedicine.symptomCardiology and Cardiovascular MedicinebusinessBiomarkersCardiovascular Diabetology
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Effects of hypocaloric diets with different glycemic indexes on endothelial function and glycemic variability in overweight and in obese adult patien…

2013

Background & aims: The role of glycemic index of the diet in glucose control and cardiovascular prevention is still not clear. The aim of this study was to determine the effects of hypocaloric diets with different glycemic indexes and glycemic loads on endothelial function and glycemic variability in nondiabetic participants at increased cardiovascular risk. Methods: Forty nondiabetic obese participants were randomly assigned to a three-month treatment with either a low glycemic index (LGI; n ¼ 19) or high glycemic index (HGI; n ¼ 21) hypocaloric diet with similar macronutrient and fiber content. Endothelial function was measured as flow-mediated dilatation (FMD) of the brachial artery befo…

AdultBlood GlucoseMalemedicine.medical_specialtyAdolescentBrachial ArteryOverweightCritical Care and Intensive Care MedicineGastroenterologyBody Mass IndexYoung AdultInsulin resistanceRisk FactorsWeight lossInternal medicineWeight LossGlycemic loadDiabetes MellitusmedicineBody Fat DistributionHumansInsulinendothelial function glycemic variability diet glycemic index glycemic load cardiovascular riskEndotheliumObesitySettore MED/49 - Scienze Tecniche Dietetiche ApplicateCaloric RestrictionGlycemicNutrition and Dieteticsbusiness.industryMiddle AgedOverweightmedicine.diseaseGlycemic indexEndocrinologyCardiovascular DiseasesGlycemic IndexBody CompositionFemaleInsulin Resistancemedicine.symptomEnergy IntakebusinessBody mass indexDietingClinical Nutrition
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Hyperinsulinemia as a determinant of microalbuminuria in essential hypertension

1997

OBJECTIVE To analyze the relationship between insulinemia and urinary albumin excretion in a group of nonobese, young adult hypertensive patients, who had never been treated with antihypertensive drugs. PATIENTS AND METHODS Forty-nine patients who fulfilled the inclusion criteria were included. Twenty-four-hour ambulatory blood pressure monitorings, urinary albumin excretion (UAE) measurements, and an oral glucose-tolerance test measuring glucose and insulin, were performed, and left ventricular mass was measured by echocardiography. Hypertensive patients were classified as normoalbuminuric when their UAE was < 30 mg/24 h (40 patients; mean UAE 13.4 +/- 7.0 mg/24 h), and as microalbuminuric…

AdultBlood GlucoseMalemedicine.medical_specialtyAmbulatory blood pressurePhysiologymedicine.medical_treatmentUrologyBlood PressureEssential hypertensionRisk FactorsHyperinsulinismInternal medicineInternal MedicineHyperinsulinemiamedicineAlbuminuriaHumansInsulinProteinuriabusiness.industryInsulinArea under the curveGlucose Tolerance TestMiddle Agedmedicine.diseaseBlood pressureEndocrinologyCardiovascular DiseasesCase-Control StudiesHypertensionFemaleMicroalbuminuriamedicine.symptomCardiology and Cardiovascular MedicinebusinessBiomarkersJournal of Hypertension
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Levels of C3 in patients with severe, morbid and extreme obesity: its relationship to insulin resistance and different cardiovascular risk factors.

2007

Increased C3 has been related to body mass index (BMI) and insulin resistance, although there are not sufficient studies in subjects with morbid obesity. The purpose of this study was to evaluate the levels of C3 as a function of the BMI in subjects of both sexes, with severe, morbid and extreme obesity, and their possible relationship to insulin resistance or associated diseases such as diabetes, hypertension and dyslipidemia.The study included a total of 316 patients (110 men and 206 women) with severe obesity (17.1%), morbid obesity (54.4%) and extreme obesity (28.4%), with an average BMI of 46.70+/-7.37 kg/m2.The glucose and insulin levels were determined baseline, and 2 h after a 75 g …

AdultBlood GlucoseMalemedicine.medical_specialtyEndocrinology Diabetes and Metabolismmedicine.medical_treatmentMedicine (miscellaneous)Blood Pressuremacromolecular substancesBody Mass IndexInsulin resistanceRisk FactorsInternal medicineEpidemiologymedicineHyperinsulinemiaHumansInsulinObesityRisk factorPancreatic hormoneDyslipidemiasNutrition and DieteticsVascular diseasebusiness.industryInsulinComplement C3medicine.diseaseObesity MorbidEndocrinologyDiabetes Mellitus Type 2Cardiovascular DiseasesHypertensionFemaleInsulin ResistancebusinessHyperinsulinismInternational journal of obesity (2005)
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