Search results for "Carotid Body"
showing 7 items of 17 documents
Miega artērijas audzēju ķirurģiska ārstēšana Latvijā no 2010. līdz 2015.gadam
2016
Ievads: Miega artēriju audzēji (MAA) ir reti, lēni augoši un labi apasiņoti neiroendokrīni veidojumi, kuru izcelsme ir miega artērijas bifurkācijas līmenī esošās paraganglionārās šūnas. Mērķis: Pētījuma mērķis bija izpētīt MAA pacientus Latvijā pēdējo piecu gadu laikā, veicot demogrāfisku, kā arī ārstēšanās iznākumu analīzi. Materiāli un metodes: Tika veikta retrospektīva analīze, caurskatot pacientu slimības vēstures no 2010. līdz 2015. gadam Paula Stradiņa Klīniskās Universitātes slimnīcā, kurā esošais asinsvadu ķirurģijas centrs ir vadošais Latvijā, kurā ārstē MAA. Pētījuma ietvaros pacienti tika arī uzaicināti uz duplex ultrasonogrāfiju apsekošanai. Rezultāti: Kopumā 10 pacientiem tika …
Chemoresponsiveness and Breath Physiology in Anosmia
2014
Anosmia is a model to study the interaction among chemoreception systems. In the head injury, the traumatic irreversible anosmia caused by damage to olfactory nerve fibers and brain regions is of enviable research interest. In this study, psychophysiological tests for a comprehensive assessment of olfactory function were utilized to investigate anosmia, together with a new technique based on the breath real-time monitoring of volatile organic compounds (VOCs). We applied the breath and VOCs analysis to investigate chemoresponsiveness in the long-term irreversible post-traumatic anosmia.
Inhibition of Peripheral Dopamine Metabolism and the Ventilatory Response to Hypoxia in the Rat
2014
Dopamine (DA) is a putative neurotransmitter in the carotid body engaged in the generation of the hypoxic ventilatory response (HVR). However, the action of endogenous DA is unsettled. This study seeks to determine the ventilatory effects of increased availability of endogenous DA caused by inhibition of DA enzymatic breakdown. The peripheral inhibitor of MAO – debrisoquine, or COMT – entacapone, or both combined were injected to conscious rats. Ventilation and its responses to acute 8 % O2 in N2 were investigated in a whole body plethysmograph. We found that inhibition of MAO augmented the hyperventilatory response to hypoxia. Inhibition of COMT failed to influence the hypoxic response. Ho…
Role of IP3 Receptors in Shaping the Carotid Chemoreceptor Response to Hypoxia But Not to Hypercapnia in the Rat Carotid Body: An Evidence Review
2020
This article addresses the disparity in the transduction pathways for hypoxic and hypercapnic stimuli in carotid body glomus cells. We investigated and reviewed the experimental evidence showing that the response to hypoxia, but not to hypercapnia, is mediated by 1,4,5-inositol triphosphate receptors (IP3R/s) regulating the intracellular calcium content [Ca2+]c in glomus cells. The rationale was based on the past observations that inhibition of oxidative phosphorylation leads to the explicit inhibition of the hypoxic chemoreflex. [Ca2+]c changes were measured using cellular Ca2+-sensitive fluorescent probes, and carotid sinus nerve (CSN) sensory discharge was recorded with bipolar electrode…
An O2-sensitive glomus cell-stem cell synapse induces carotid body growth in chronic hypoxia.
2013
Summary Neural stem cells (NSCs) exist in germinal centers of the adult brain and in the carotid body (CB), an oxygen-sensing organ that grows under chronic hypoxemia. How stem cell lineage differentiation into mature glomus cells is coupled with changes in physiological demand is poorly understood. Here, we show that hypoxia does not affect CB NSC proliferation directly. Rather, mature glomus cells expressing endothelin-1, the O 2 -sensing elements in the CB that secrete neurotransmitters in response to hypoxia, establish abundant synaptic-like contacts with stem cells, which express endothelin receptors, and instruct their growth. Inhibition of glomus cell transmitter release or their sel…
Die Rolle der Farbduplexsonographie bei Diagnose und Differentialdiagnose von Glomus-caroticum-Tumoren*
1996
BACKGROUND Currently the diagnosis of tumorous lesions of the carotid bifurcation is the domain of magnetic resonance imaging (MRI) and digital subtraction angiography (DSA). So far, colour Doppler imaging (CDI) has not been playing an important part in this field. The aim of this study was to define the diagnostic value of CDI in the evaluation of these tumours related to the big arteries and to compare the different imaging techniques. PATIENTS AND METHODS 6 female patients with suspected tumours of the carotid bifurcation were examined with CDI. Additionally 5 MRI examinations and 3 preoperative diagnostic DSA examinations were performed in the same patients. Pathologically, there were 4…