Search results for "Case"
showing 10 items of 3855 documents
Do Software Firms Collaborate or Compete? A Model of Coopetition in Community-initiated OSS Projects
2019
[Background] An increasing number of commercial firms are participating in Open Source Software (OSS) projects to reduce their development cost and increase technical innovativeness. When collaborating with other firms whose sought values are conflicts of interests, firms may behave uncooperatively leading to harmful impacts on the common goal. [Aim] This study explores how software firms both collaborate and compete in OSS projects. [Method] We adopted a mixed research method on three OSS projects. [Result] We found that commercial firms participating in community-initiated OSS projects collaborate in various ways across the organizational boundaries. While most of firms contribute little,…
A classical phenotype of Anderson-Fabry disease in a female patient with intronic mutations of the GLA gene: a case report
2012
Abstract Background Fabry disease (FD) is a hereditary metabolic disorder caused by the partial or total inactivation of a lysosomal hydrolase, the enzyme α-galactosidase A (GLA). This inactivation is responsible for the storage of undegraded glycosphingolipids in the lysosomes with subsequent cellular and microvascular dysfunction. The incidence of disease is estimated at 1:40,000 in the general population, although neonatal screening initiatives have found an unexpectedly high prevalence of genetic alterations, up to 1:3,100, in newborns in Italy, and have identified a surprisingly high frequency of newborn males with genetic alterations (about 1:1,500) in Taiwan. Case presentation We des…
Serological Levels of Anti-clathrin Antibodies Are Decreased in Patients With Pseudoexfoliation Glaucoma
2021
Evidence for immunologic contribution to glaucoma pathophysiology is steadily increasing in ophthalmic research. Particularly, an altered abundance of circulating autoantibodies to ocular antigens is frequently observed. Here, we report an analysis of autoantibody abundancies to selected antigens in sera of open-angle glaucoma patients, subdivided into normal-tension glaucoma (N = 31), primary open-angle glaucoma (N = 43) and pseudoexfoliation glaucoma (N = 45), vs. a non-glaucomatous control group (N = 46). Serum samples were analyzed by protein microarray, including 38 antigens. Differences in antibody levels were assessed by ANOVA. Five serological antibodies showed significantly altered…
Endothelial nitric oxide synthase gene polymorphisms and cardiovascular damage in hypertensive subjects: an Italian case-control study
2008
Abstract Background Nitric oxide (NO) synthesized by endothelial nitric oxide synthase (eNOS) plays an important role in regulation of endothelial function and in the control of blood pressure. However, the results from some studies on the association between three clinically relevant eNOS gene polymorphisms (G894T, T786C and intron 4b/a) and essential hypertension are unclear. We designed a case-control study to evaluate the influence of eNOS polymorphisms on target organ damage in 127 hypertensives and 67 normotensives. Clinical evaluation, biochemical parameters, Urinary Albumin Excretion (UAE) and echocardiogram were performed to characterize target organ damage. eNOS polymorphism were …
Subject case alternation in negated existential, locative, and possessive clauses in Latvian
2018
[full article and abstract in English]
 The goal of this article is to analyse the alternation between the genitive and nominative cases in Latvian. As the alternation between genitive and nominative cases is possible in all clauses in which the verb būt ‘to be’ is used as an independent verb, this article examines existential, locative, and also possessive clauses, while also demonstrating that distinguishing these clause types is problematic for Latvian utilising the criteria given in the linguistic literature. Clauses containing the negative form of būt ‘to be’, i.e. nebūt, form the foundation of those selected for this study, as only in these sentences the genitive/nominative alter…
Lexicographic studies in medicine: Academic Word List for clinical case histories
2013
Medical texts are often thought to pertain to a closed community, but how far the language used by that community overlaps with general academic lexis is unknown. We examined a corpus of clinical case histories using the software RANGE to characterise the lexis of clinical case histories quantitatively and present a wordlist for clinical medicine. Only 58% of the general academic wordlists are found in clinical texts but the 85% overlap with an important academic wordlist, the Coxhead 570, furnishes evidence for the academic nature of the lexis used for clinical cases in Medicine. There was little overlap (38%) between our clinical case wordlist and other wordlists of medical research artic…
Magnetic Resonance Imaging-Guided Focused Ultrasound Surgery for the Treatment of Symptomatic Uterine Fibroids
2017
Uterine fibroids, the most common benign tumor in women of childbearing age, may cause symptoms including pelvic pain, menorrhagia, dysmenorrhea, pressure, urinary symptoms, and infertility. Various approaches are available to treat symptomatic uterine fibroids. Magnetic Resonance-guided Focused Ultrasound Surgery (MRgFUS) represents a recently introduced noninvasive safe and effective technique that can be performed without general anesthesia, in an outpatient setting. We review the principles of MRgFUS, describing patient selection criteria for the treatments performed at our center and we present a series of five selected patients with symptomatic uterine fibroids treated with this not y…
Can radium 223 be a conservative non-surgical management of medication-related osteonecrosis of the jaw?
2019
AbstractOsteonecrosis of the jaw (ONJ) is a rare and severe necrotic bone disease reflecting a compromise in the body's osseous healing mechanisms and unique to the craniofacial region. Radium 223 dichloride (Ra223) is the only targeted alpha therapy able to extend survival in patients with bone metastases from prostate cancer. Mechanism of action and data currently available focused mainly on osteoblastic metastases from prostate cancer. In 2018, a Caucasian 54-year-old woman presented to our institution for a breast cancer with bone metastases. Since the patient refused any treatment and taking into account the bone disease, our multidisciplinary team evaluated a supplementary strategy wi…
Endovascular treatment of spontaneous isolated abdominal aortic dissection
2016
Isolated abdominal aortic dissection is a rare clinical disease representing only 1.3% of all dissections. There are a few case series reported in the literature. The causes of this pathology can be spontaneous, iatrogenic, or traumatic. Most patients are asymptomatic and symptoms are usually abdominal or back pain, while claudication and lower limb ischemia are rare. Surgical and endovascular treatment are two valid options with acceptable results. We herein describe nine cases of symptomatic spontaneous isolated abdominal aortic dissection, out of which four successfully were treated with an endovascular approach between July 2003 and July 2013. All patients were men, smokers, symptomati…
Diagnosis of exon 12‐positive polycythemia vera rescued by NGS
2020
Abstract A JAK2V617F‐negative polycythemia associated with low serum epo needs to be tested for an exon 12 JAK2 mutation. When negative, due to potential serious complications in PV, a next generation sequencing is necessary to rule out false negative results.