Search results for "Catenin"
showing 3 items of 83 documents
Understanding the effect of Vitamin D treatment on human uterine leiomyoma growth using in vitro and in vivo models
2019
Los miomas uterinos afectan al 70% de las mujeres en edad reproductiva, empeorando la calidad de vida de muchas de ellas debido a sus síntomas asociados. A pesar de su alta prevalencia no existe ninguna terapia efectiva para reducir el tamaño de éstos mínimamente invasiva y sin efectos secundarios. Aunque la patogénesis de los miomas no se conoce completamente, la correlación entre el déficit de Vitamina D (Vit D) y el riesgo de miomas uterinos, junto sus efectos antiproliferativos descritos en cáncer, apuntaron a la Vit D como una posible opción terapéutica para tratar los miomas uterinos. En este sentido, la acción de la Vit D ha sido ampliamente estudiada en cáncer, demostrando que su ac…
Targeting HSP90 with the small molecule inhibitor AUY922 (luminespib) as a treatment strategy against hepatocellular carcinoma
2018
Hepatocellular carcinoma (HCC) is a highly malignant tumor that responds very poorly to existing therapies, most probably due to its extraordinary inter- and intra-tumor molecular heterogeneity. The modest therapeutic response to molecular targeted agents underlines the need for new therapeutic approaches for HCC. In our study, we took advantage of well-characterized human HCC cell lines, differing in transcriptomic subtypes, DNA mutation and amplification alterations, reflecting the heterogeneity of primary HCCs, to provide a preclinical evaluation of the specific heat shock protein 90 (HSP90) inhibitor AUY922 (luminespib). Indeed, HSP90 is highly expressed in different tumor types, but it…
Comparative histological and immunohistochemical study of ameloblastomas and ameloblastic carcinomas
2017
Background This study aimed to compare the histological and immunohistochemical characteristics of ameloblastomas (AM) and ameloblastic carcinomas (AC). Material and Methods Fifteen cases of AM and 9 AC were submitted to hematoxilin and eosin (H&E) and immunohistochemical analysis with the following antibodies: cytokeratins 5,7,8,14 and 19, Ki-67, p53, p63 and the cellular adhesion molecules CD138 (Syndecan-1), E-cadherin and β-catenin. The mean score of the expression of Ki-67 and p53 labelling index (LIs) were compared between the groups using the t test. A value of p<0.05 was considered to be statistically significant. Results All cases were positive for CKs 5, 14 and 19, but negative fo…