Search results for "Celia"
showing 10 items of 269 documents
Non-celiac wheat sensitivity and ANA positivity: is there any association with autoimmune disease?
2016
Introduction: In the last decade non-celiac wheat sensitivity (NCWS) has raised great interest but unfortunately little is known about the risks linked to this condition. Our study aimed to evaluate the frequency of autoimmune diseases (AIDs) and of serum anti-nuclear antibodies (ANA) in these patients. Materials and Methods: We recruited 131 NCWS patients (121 F, mean age 39.1 years), belonging to a historical cohort retrospectively evaluated, at two Internal Medicine Institutes. Two groups of age- and sex-matched controls, respectively composed of celiac (CD) and irritable bowel syndrome (IBS) patients, were also chosen. Co-existent of AIDs was recorded by a pre-structured questionnaire. …
Non-celiac wheat sensitivity: a search for the pathogenesis of a self-reported condition
2019
A significant percentage of the general population reports gastrointestinal and non-gastrointestinal symptoms caused by wheat and/or gluten ingestion, even though they do not suffer from celiac disease (CD) or wheat allergy (WS), because they test negative both for CD-specific serology and histopathology. All patients report improvement of symptoms on a gluten-free diet. This clinical condition has been named non-celiac gluten sensitivity (NCGS). The objective of this paper was to review some studies regarding the pathogenesis of NCGS to summarize the current hypotheses about the mechanisms, which can lead to NCGS. Particular attention was given to the immunologic and the malabsorptive hypo…
Rectal mucosa inflammation in non-celiac wheat sensitivity: comparison with duodenal histology.
2018
Background and Aims: In recent years an increasing number of studies on Non-Celiac Gluten/Wheat Sensitivity (NCG/WS) have been published but no markers of this condition have as yet been found. Although the NCG/WS clinical presentation often overlaps with IBS, no previous study evacuate colon or rectal histology in NCG/WS patients. Patients and Methods: We performed a prospective study on 78 patients (66 females, 12 males, mean age 36. 4 years) diagnosed with NCG/WS by double-blind wheat challenge, presenting at two tertiary care centers in Italy from January 2015 through September 2016. Data were also collected from 55 control patients either with celiac disease (CD) or with self-reported …
Frequency Of Self-Reported Non-Celiac Wheat Sensitivity In School-Age Adolescents In Italy Epidemiological And Clinical Data.
2018
Non-Celiac Wheat Sensitivity (NCWS) has recently been included among the gluten-related disorders. As no biomarkers of this disease exist, its frequency has been estimated based on self-reported symptoms, but to date no data are available about self-reported NCWS in teenagers. AIM: To explore the prevalence of self-reported NCWS in a group of high school students and to study their demographic and clinical characteristics. METHODS: The study was performed between April 2015 and January 2016 in two high schools of a coastal town in the south of Sicily (Italy).
Vitamin B12 deficiency with multiple sclerosis-like neurological clinical framework.
2012
ANEMIA RESISTANT TO THE GLUTEN-FREE DIET IN CELIAC DISEASE PATIENTS: IS IT JUST A MALABSORPTION PROBLEM?: ANEMIA RESISTANT TO GFD IN CD PATIENTS
2022
IPERSENSIBILITÀ AL GLUTINE NELL’ANZIANO. PRESENTAZIONE DI UN CASO CLINICO
2015
La celiachia è una malattia immunomediata scatenata dall’ingestione di glutine che, in soggetti geneticamente predisposti, determina un processo infiammatorio intestinale con conseguente malassorbimento e manifesta-zioni extraintestinali. Fino ad alcuni anni fa era considerata una patologia rara, tipica dell’età infantile; lo scenario epidemiologico della celiachia, oggi, è totalmente cambiato, grazie anche all’introduzione di test sierologici ad elevata sensibilità e specificità come gli anticorpi anti-endomisio (EMA) e gli anticorpi anti-transglutaminasi tissutale (tTG). Studi epidemiologici basati sull’impiego dei test sierologici hanno dimostrato che la diagnosi di celiachia viene sempr…
Celiac disease in older persons: A case of seronegative disease
2017
A 68-year-old man with a history of smoking (former smoker of 40 cigarettes per day), euthyroid goiter, deep vein thrombosis and depression, came to our attention for weakness, cachexia, abdominal bloating and diarrhea lasting for almost six months. Furthermore, he had lost about 25 kilograms of weight in the last year and was bedridden for three months. Combining the results of serological, histopathological and genetic tests, he was diagnosed with a seronegative celiac disease. Gluten-free diet, combined with nutritional supplements and physical therapy, improved his clinical condition and allowed the recovery of weight and the walking ability. Celiac disease might be suspected in elderly…
Reduction of mineral bone density i n patients with non-celiac wheat- and multiple food sensitivity.
2014
The Gliadin Hydrolysis Capacity of B. longum, L. acidophilus, and L. plantarum and Their Protective Effects on Caco-2 Cells against Gliadin-Induced I…
2023
Background: Non-celiac wheat sensitivity (NCWS) is a poorly understood gluten-related disorder (GRD) and its prominent symptoms can be ameliorated by gluten avoidance. This study aimed to determine the effectiveness of a probiotic mixture in hydrolyzing gliadin peptides (toxic components of gluten) and suppressing gliadin-induced inflammatory responses in Caco-2 cells. Methods: Wheat dough was fermented with a probiotic mix for 0, 2, 4, and 6 h. The effect of the probiotic mix on gliadin degradation was monitored by SDS-PAGE. The expression levels of IL-6, IL-17A, INF-G, IL-10, and TGF-B were evaluated using ELISA and qRT-PCR methods. Results: According to our findings, fermenting wheat dou…