Search results for "Cerebrovascular diseases"

showing 3 items of 23 documents

Caspase-3 contributes to ZO-1 and Cl-5 tight-junction disruption in rapid anoxic neurovascular unit damage.

2011

BACKGROUND: Tight-junction (TJ) protein degradation is a decisive step in hypoxic blood-brain barrier (BBB) breakdown in stroke. In this study we elucidated the impact of acute cerebral ischemia on TJ protein arrangement and the role of the apoptotic effector protease caspase-3 in this context. METHODOLOGY/PRINCIPAL FINDINGS: We used an in vitro model of the neurovascular unit and the guinea pig whole brain preparation to analyze with immunohistochemical methods the BBB properties and neurovascular integrity. In both methodological approaches we observed rapid TJ protein disruptions after 30 min of oxygen and glucose deprivation or middle cerebral artery occlusion, which were accompanied by…

Time FactorsAnatomy and Physiologylcsh:MedicineMiceMolecular Cell BiologyPathologySignaling in Cellular ProcessesHypoxia Brainlcsh:ScienceCells CulturedNeuropathologyApoptotic SignalingMultidisciplinaryTight junctionCaspase 3ChemistryAnimal ModelsCell biologyTransport proteinProtein Transportmedicine.anatomical_structureNeurologyBlood-Brain BarrierMedicineResearch ArticleSignal TransductionClinical Research DesignCerebrovascular DiseasesGuinea PigsIschemiaContext (language use)Caspase 3Protein degradationBlood–brain barrierNeurological SystemTight JunctionsCapillary PermeabilityModel OrganismsDiagnostic MedicinemedicineAnimalsTransient Ischemic AttacksAnimal Models of DiseaseClaudinBiologyIschemic Strokelcsh:REndothelial CellsMembrane ProteinsPhosphoproteinsmedicine.diseaseAnatomical PathologyClaudinsImmunologyZonula Occludens-1 ProteinNervous System Componentslcsh:QPLoS ONE
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Agenesis of the Internal Carotid Artery Associated with Generalized Epilepsy

2018

medicine.medical_specialtyEpilepsybusiness.industrymedicine.diseaseGenesis of internal carotid arterycerebrovascular diseases; carotid artery; epilepsy; magnetic resonance imaging; agenesis030207 dermatology & venereal diseases03 medical and health sciences0302 clinical medicineText miningNeurologyInternal medicinemedicine.arteryAgenesisEpilepsy Genesis of internal carotid artery Case reportCase reportmedicineCardiologyNeurology (clinical)Generalized epilepsyInternal carotid arterybusinessLetter to the Editor030217 neurology & neurosurgeryJournal of Clinical Neurology (Seoul, Korea)
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Relationship between Diabetes and Ischemic Stroke: Analysis of Diabetes- Related Risk Factors for Stroke and of Specific Patterns of Stroke Associate…

2015

Diabetes and ischemic stroke are common diseases that frequently occurring together. Among patients with diabetes mellitus several factors contribute in varying degrees to the overall cerebrovascular risk including hyperglycemia, vascular risk factors such as hypertension and dyslipidemia and also genetic, demographic, and lifestyle factors and several studies have shown that people with diabetes have approximately twice the risk of ischemic stroke compared with those without diabetes. The association between ischemic stroke and diabetes is bidirectional and it is not limited to acute ischemic stroke since diabetes may contribute to a more insidious brain damage represented by lacunar infar…

medicine.medical_specialtybusiness.industryCerebrovascular diseasesBrain damageDiabetemedicine.diseaseOmicsSurgeryStrokeDiabetes mellitusInternal medicineIschemic strokemedicineDementiacardiovascular diseasesRisk factormedicine.symptombusinessStrokeDyslipidemiaJournal of Diabetes & Metabolism
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