Search results for "Cero"

Morphological aspects of the neuronal ceroid lipofuscinoses

2000

Morphological aspects of the neuronal ceroid lipofuscinoses (NCL) encompass two main features: loss of nerve cells and accumulation of autofluorescent lipopigments within cellular compartments. The former requires histology and morphometry for assessment, while the latter necessitates fluorescence microscopy, electron microscopy, and immunohistochemistry. Accumulation of lipopigments is widespread throughout the central nervous system and extracerebrally. The latter feature enables diagnosis of NCL and its clinical subtype. Loss of neurons is most pronounced in cerebral and cerebellar cortices, in early childhood forms. In subcortical grey matter and in later-onset forms, juvenile and adult…

Metabolic profiling reveals distinct variations linked to nicotine consumption in humans--first results from the KORA study.

2008

Exposure to nicotine during smoking causes a multitude of metabolic changes that are poorly understood. We quantified and analyzed 198 metabolites in 283 serum samples from the human cohort KORA (Cooperative Health Research in the Region of Augsburg). Multivariate analysis of metabolic profiles revealed that the group of smokers could be clearly differentiated from the groups of former smokers and non-smokers. Moreover, 23 lipid metabolites were identified as nicotine-dependent biomarkers. The levels of these biomarkers are all up-regulated in smokers compared to those in former and non-smokers, except for three acyl-alkyl-phosphatidylcholines (e.g. plasmalogens). Consistently significant r…

Expression and inducibility of drug-metabolizing enzymes in preneoplastic and neoplastic lesions of rat liver during nitrosamine-induced hepatocarcin…

1987

The expression, inducibility, and regulation of four different cytochrome (cyt.) P-450 isoenzymes (PB1, PB2, MC1, and MC2) NADPH-cytochrome P-450 reductase, the glutathione transferases (GSTs) B and C and microsomal epoxide hydrolase (mEHb) have been studied during nitrosamine-induced hepatocarcinogenesis using immunohistochemical techniques. The investigations revealed basic differences in the expression of the individual drug metabolizing enzymes in the course of neoplastic development. While the two GSTs and mEHb were increased in all preneoplastic and benign neoplastic lesions, the levels of the distinct cyt. P-450 isoenzymes were characteristically different from each other. Following …

El sentido alusivo de singularis en el discurso ciceroniano pro Sulla

2012

Después de haber propuesto que el uso frecuente de singularis en las Verrinas está en buena parte motivado por la alusión aprina que suscitan los nombres parlantes de Verres y de su principal colaborador Apronius, se nos ha opuesto el reparo de que el uso relativo de ese adjetivo es superior en el Pro Sulla. Pues bien, hecho el oportuno análisis, comprobamos que dos de los seis empleos de singularis en este discurso apuntan el mismo valor alusivo. Y los motivos son paralelos: Sulla facilita la conexión con el término genérico del cerdo doméstico o salvaje (sus, suis) y la conducta predatoria del personaje justifi ca la alusión, como en el caso de las Verrinas

Neuronal ceroid-lipofuscinoses: The current status

1992

In view of the epidemiological connotation of childhood neuronal ceroid-lipofuscinosis (NCL) as one of the most frequent progressive lysosomal diseases and neurodegenerative disorders in children, the recognition of the individual clinical forms of childhood NCL is still based on invasive diagnostic electronmicroscopy which, currently, may be applied also for prenatal diagnosis. Like other inherited disorders, the NCL group has finally also benefited from the genetic breakthroughs of localization of the genes for infantile NCL and juvenile NCL on chromosomes 1 and 16, respectively. This review concerns recent advances in morphological studies, broadening of the clinical spectrum of childhoo…

IN CELLULE DI OSTEOSARCOMA UMANO MG-63, IL TRATTAMENTO CON 3-AMINOBENZAMIDE FAVORISCE L’ESPANSIONE DI UNA POPOLAZIONE CELLULARE “STEM-LIKE”

2009

Clinical correlates of change in inflammatory biomarkers: The Framingham Heart Study

2013

Objectives: Traditional clinical risk factors are associated with inflammation cross-sectionally, but associations of longitudinal variation in inflammatory biomarkers with corresponding changes in clinical risk factors are incompletely described. We sought to analyze clinical factors associated with change in inflammation in the community.Methods: We studied 3013 Framingham Offspring (n = 2735) and Omni Cohort (n = 278) participants (mean age 59 years, 55% women, 9% ethnic/racial minority) who attended two consecutive examination cycles (mean 6.7 years apart). We selected ten inflammatory biomarkers representing distinctive biological functions: C-reactive protein (CRP), intercellular adhe…

Gene signatures in CRC and liver metastasis

2011

Colorectal cancer (CRC) is one of the most common causes of cancer-related death with a worldwide incidence of almost a million cases annually in both males and females. The accelerated decrease in CRC incidence rates from 1998 to 2006 largely reflects the advances in diagnosis and treatment that have enabled to detect and remove precancerous polyps. However, the screening technology has not resulted in major improvements in the prognosis of patients with advanced cancer and the liver metastasis remains the major cause of death in CRC. About 25% of patients have detectable liver metastasis at diagnosis, that are classified as “synchronous” lesions and approximately 70% of patients develop a…

Il Palazzo Reale di Palermo in età moderna (XVI-XVII secolo)

2012

Il "Sacruma Regium Palatium" di Palermo rapppresenta nell'immaginario collettivo siciliano la testimonianza materiale più illustre dei fasti della corona d'Altavilla e in particolare dell'età ruggeriana: non a caso ancora oggi il complesso prende il nome di "Palazzo dei Normanni". Come è noto, tuttavia, il complesso ha una storia millenaria, che con lo snodarsi dei secoli ha conosciuto vicende alterne e momenti di decadimento. Questo libro è dedicato alla "rinascenza" del palazzo, cioè a quella fase del suo iter architettonico in cui, dopo due secoli di abbandono, torna a ricoprie il suo ruolo istituzionale di sede dell'autorità monarchica in Sicilia. La decisione presa da nel 1553 dal vice…

Grafting of hyperbranched polymers: From unusual complex polymer topologies to multivalent surface functionalization

2013

Abstract In this feature article, the grafting of hyperbranched polymers to different substrates is reviewed. Both grafting onto macromolecules with different topologies (homogeneous grafting) and the resulting complex polymer architectures containing highly branched segments as well as their applications are discussed. In the second part grafting of hyperbranched polymers on surfaces, i.e., planar surfaces and spherical particles (heterogeneous grafting), with respect to specific applications, such as bio-repellent surfaces or soluble carbon nanotubes is described. In all cases, the one-step synthesis and the resulting highly branched topology of the hyperbranched building blocks is benefi…