Search results for "Cervell"
showing 10 items of 32 documents
Papel de la eminencia talámica, el sistema olfativo principal y el sistema olfativo accesorio en la maduración sexual del encéfalo y las manifestacio…
2014
El desarrollo de sistema olfativo y la diferenciación sexual del encéfalo, tanto en el hombre como en los animales, están estrechamente relacionados. Actualmente, se describe la imbricación entre la formación del sistema olfativo principal y la migración de las neuronas que sintetizan la hormona liberadora de gonadotrofinas (GnRF). Estas neuronas GnRF se desplazan por los nervios olfatorios, desde la parte medial del epitelio nasal al bulbo olfatorio, continúan por el encéfalo rostral hasta alcanzar el hipotálamo anterior. Por otro lado, el síndrome de Kallmann es un trastorno genético en el cual se combina el hipogonadismo hipogonadotrópico y la anosmia. El hipogonadismo se caracteriza por…
Amphiphilic peptide-tagged N-cadherin forms radial glial-like fibers that enhance neuronal migration in injured brain and promote sensorimotor recove…
2023
The mammalian brain has very limited ability to regenerate lost neurons and recover function after injury. Promoting the migration of young neurons (neuroblasts) derived from endogenous neural stem cells using biomaterials is a new and promising approach to aid recovery of the brain after injury. However, the delivery of sufficient neuroblasts to distant injured sites is a major challenge because of the limited number of scaffold cells that are available to guide neuroblast migration. To address this issue, we have developed an amphiphilic peptide [(RADA)3-(RADG)] (mRADA)-tagged N-cadherin extracellular domain (Ncad-mRADA), which can remain in mRADA hydrogels and be injected into deep brain…
The maternal hormone in the male brain: Sexually dimorphic distribution of prolactin signalling in the mouse brain.
2018
Research of the central actions of prolactin is highly focused on females, but this hormone has also documented roles in male physiology and behaviour. Here, we provide the first description of the pattern of prolactin-derived signalling in the male mouse brain, employing the immunostaining of phosphorylated signal transducer and activator of transcription 5 (pSTAT5) after exogenous prolactin administration. Next, we explore possible sexually dimorphic differences by comparing pSTAT5 immunoreactivity in prolactin-supplemented males and females. We also assess the role of testosterone in the regulation of central prolactin signalling in males by comparing intact with castrated prolactin-supp…
DIENCEFALO: TALAMO-IPOTALAMO. TERMOREGOLAZIONE; REGOLAZIONE DI EQUILIBRIO IDRICO, APPORTO ALIMENTARE E CICLO MESTRUALE
2008
The relationship between genetic risk variants with brain structure and function in bipolar disorder: A systematic review of genetic-neuroimaging stu…
2017
Genetic-neuroimaging paradigms could provide insights regarding the pathophysiology of bipolar disorder (BD). Nevertheless, findings have been inconsistent across studies. A systematic review of gene-imaging studies involving individuals with BD was conducted across electronic major databases from inception until January 9th, 2017. Forty-four studies met eligibility criteria (N = 2122 BD participants). Twenty-six gene variants were investigated across candidate gene studies and 4 studies used a genome-wide association approach. Replicated evidence (i.e. in >2 studies) suggests that individuals with BD carrying the BDNF Val66Met risk allele could have reduced hippocampal volumes compared …
Thyroid hormones and the central nervous system of mammals (Review)
2008
Abstract. The thyroid hormones (THs) L-thyroxine (T4) and L-triiodothyronine (T3) have a profound influence on the development and maturation of the mammalian brain, both before and after birth. Any impairment in the supply of THs to the developing nervous system leads to severe and irreversible changes in both the overall architecture and functions of the brain and causes, in humans, neurological and motor deficits known as cretinism. Pronounced neurological symptoms are also commonly observed in adult patients suffering from both hyperthyroidism and hypothyroidism, and it has recently emerged that certain symptoms might result from the reduced brain uptake, rather than the insufficient pr…
La ciència com a cerca. Don Quixot, la neurociència i l'interrogatori de la veritat
2014
El neurocientifi c Rodrigo Quian Quiroga es va preguntar si «els cientifi cs, embarcats en cerques personals i quixotesques croades, es passen el temps pensant». Aquesta invocacio adjectival del Quixot de Cervantes presenta la ciencia com una cerca epica que equipara la racionalitat cientifi ca amb els deliris de Don Quixot. Es la cerca de la veritat per part de la ciencia, quixotesca i literaria, un «racionalisme neurotic», en paraules del fi losof Nicholas Maxwell?
El testament del marqués de Villatorcas i la disputa del compte de Cervelló per l'herència paterna : una altra conseqüència de l'exili austracista.
2007
Felipo Orts, Amparo - Amparo.Felipo@uv.es En el context de les conseqüències de l'exili austriacista vinculat a la Guerra de Successió, aquest article estudia els desencontres familiars que va haver de salvar don Juan Basilio de Castellví, exiliat a Viena, per a veure reconeguts els seus drets a la part de l'herència familiar que assegurava correspondreli, derivats, al seu torn, del conflicte personal que per a son pare, el marqués de Villatorcas, va haver de suposar la necessitat de disposar les seues últimes voluntats -en forma de poder públic- abans de la firma de la Pau de Viena de 1725.
IL NEGLECT COME PRINCIPALE RESPONSABILE DELLA PERDITA DI AUTONOMIA E AUTOSUFFICIENZA IN SOGGETTO AFFETTO DA DECLINO COGNITIVO DI GRADO LIEVE
2017
La negligenza spaziale unilaterale è una delle patologie più frequentemente riscontrate dopo un danno cerebrale all’emisfero destro (40%-81%) e consiste in un deficit di consapevolezza dello spazio contro- lesionale. È una condizione neurologica e neuropsicologica caratterizzata dal danneggiamento di particolari zone del cervello: la persona non presta più attenzione a una porzione dello spazio interessato. Esistono tre tipi di neglect: il neglect dello spazio personale impedisce al paziente la consapevolezza dell’emisoma contro-lesionale; pazienti che presentano questa patologia avranno difficoltà nel vestirsi o nel lavare la metà del corpo contro-laterale rispetto alla lesione; il neglect…