Search results for "Cg"

showing 10 items of 999 documents

Pan-cancer analysis of whole genomes

2020

Publisher's version (útgefin grein)

Maletert promoter mutationsCancer development and immune defence Radboud Institute for Molecular Life Sciences [Radboudumc 2]DNA Mutational AnalysisNormal tissuesystematic analysisGermlineTranscriptome0302 clinical medicineAetiologyCàncerCellular SenescenceCancer0303 health sciencesdna-damageMassive parallel sequencingPan cancerREARRANGEMENTSHigh-Throughput Nucleotide SequencingGenomicsSciences bio-médicales et agricolesTelomereCOMPREHENSIVE3. Good healthTERT PROMOTER MUTATIONSsignatures030220 oncology & carcinogenesisScience & Technology - Other TopicsErfðarannsóknirHuman:Informàtica::Aplicacions de la informàtica::Bioinformàtica [Àrees temàtiques de la UPC]EvolutionRNA SplicingGenomicsArticleEvolution MolecularStructural variationRC025403 medical and health sciencesSDG 3 - Good Health and Well-beingGeneticgenomicsSYSTEMATIC ANALYSISGeneticsGenomics--Databases.HumansGenetic TestingMolecular BiologySIGNATURESWhole genome sequencing1000 MultidisciplinaryChromothripsisScience & TechnologyRC0254 Neoplasms. Tumors. Oncology (including Cancer)Information DisseminationResearchInstitutes_Networks_Beacons/mcrcPreventionBiology and Life SciencesMolecularOncogenesCloud Computingmedicine.diseaseGenòmicaCompute cloudsMutation570 Life sciences; biologyCOMPREHENSIVE CHARACTERIZATIONGenèticaWhole Genome Sequencing--methodsBackground informationDNA Mutational Analysis ; Evolution ; Genetic / genetics ; Genome ; Genomics ; Germ-Line Mutation / genetics ; High-Throughput Nucleotide Sequencing ; Human / genetics ; Humans ; ICGC/TCGA Pan-Cancer Analysis of Whole Genomes ConsortiumMedizinGenomeWhole-genomeGenome mappingNeoplasms2.1 Biological and endogenous factorsPromoter Regions GeneticCàncer -- Aspectes genèticsTelomeraseGeneticsWomen's cancers Radboud Institute for Molecular Life Sciences [Radboudumc 17]MultidisciplinaryChromothripsisGenomeManchester Cancer Research Centregenomics cancer profiling3rd-DAS10124 Institute of Molecular Life SciencesWomen's cancers Radboud Institute for Health Sciences [Radboudumc 17]Multidisciplinary SciencesParallel sequencingICGC/TCGA Pan-Cancer Analysis of Whole Genomes ConsortiumFemaleprofilingMedical GeneticsEngineering sciences. TechnologyBiotechnologyGeneral Science & TechnologyThe Cancer Genome Atlas610 Medicine & healthComputational biologyQH426 GeneticsBiologyConsortium of the International Cancer Genome ConsortiumPromoter RegionsGermline mutationPan-cancer analysisKrabbameinsrannsóknirmedicinecancerddc:610QH426Germ-Line MutationMedicinsk genetikKrabbamein030304 developmental biologyCell ProliferationLANDSCAPEGenome Humancomprehensive characterizationPan-cancer analysis of whole genomesPoint mutationHuman GenomeCancerReproducibility of ResultsSOMATIC MUTATIONSEVOLUTIONCancer sequencing Chromothripsis telomereDNA-DAMAGEMutagenesisPATTERNS3111 BiomedicineCHARACTERIZATION
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Late Pleistocene (MIS 3-4) climate inferred from micromammal communities and δ18O of rodents from Les Pradelles, France.

2013

The middle Paleolithic stratigraphic sequence of Les Pradelles (Charente, France) spans from the end of Marine Isotope Stage (MIS) 4 until the middle of MIS 3. Micromammal remains are present in all the stratigraphic levels, offering a rare opportunity to address the questions of both environmental and climatic fluctuations throughout this period. Climate modes were studied through the taphonomy, biodiversity and oxygen isotope compositions of phosphate (δ18O p ) from 66 samples of rodent tooth enamel. The δ18O p values from the lower sedimentary levels provide summer mean air temperatures of 19 ± 2°C (level 2/1) and of 16 ± 2°C (levels 2A, 2B and 4A). Within the middle of sequence (level 4…

Marine isotope stage010506 paleontologyTaphonomy010504 meteorology & atmospheric sciencesPleistoceneClimate[SDE.MCG]Environmental Sciences/Global ChangesPhosphate01 natural sciencesArts and Humanities (miscellaneous)[SDU.STU.GC]Sciences of the Universe [physics]/Earth Sciences/GeochemistryMiddle PaleolithicSmall mammalsDicrostonyx torquatusSequence stratigraphyMicrotus0105 earth and related environmental sciencesEarth-Surface Processes[ SDU.STU.PG ] Sciences of the Universe [physics]/Earth Sciences/PaleontologyRodentbiologyEcology15. Life on landbiology.organism_classification[ SDU.STU.GC ] Sciences of the Universe [physics]/Earth Sciences/GeochemistryLes PradellesOxygen isotopePleistocene[ SDE.MCG ] Environmental Sciences/Global Changes13. Climate actionPaleoecologyGeneral Earth and Planetary Sciences[SDU.STU.PG]Sciences of the Universe [physics]/Earth Sciences/Paleontology
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Solving the pentahedron problem

2015

Nowadays, all geometric modelers provide some tools for specifying geometric constraints. The 3D pentahedron problem is an example of a 3D Geometric Constraint Solving Problem (GCSP), composed of six vertices, nine edges, five faces (two triangles and three quadrilaterals), and defined by the lengths of its edges and the planarity of its quadrilateral faces. This problem seems to be the simplest non-trivial problem, as the methods used to solve the Stewart platform or octahedron problem fail to solve it. The naive algebraic formulation of the pentahedron yields an under-constrained system of twelve equations in eighteen unknowns. Even if the use of placement rules transforms the pentahedron…

Mathematical optimization[ INFO ] Computer Science [cs]Interval (mathematics)[INFO.INFO-CG]Computer Science [cs]/Computational Geometry [cs.CG]Industrial and Manufacturing EngineeringDesargues’ theoremPolyhedronAl-Kashi theorem[INFO]Computer Science [cs]Algebraic numberFinite setMathematicsGeometric constraint solving problemsQuadrilateralGeometric modeling with constraintsSolution set[ MATH.MATH-NA ] Mathematics [math]/Numerical Analysis [math.NA]SolverComputer Graphics and Computer-Aided DesignPentahedronPentahedronComputer Science ApplicationsAlgebraInterval solver[ INFO.INFO-CG ] Computer Science [cs]/Computational Geometry [cs.CG][MATH.MATH-NA]Mathematics [math]/Numerical Analysis [math.NA]
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Bayesian calibration of the nitrous oxide emission module of an agro-ecosystem model

2008

1. NitroEurope Open Science Conference on Reactive Nitrogen and the European Greenhouse Gas Balance ; Ghent (Belgique) - (2008-02-20 - 2008-02-21) / Conférence; Nitrous oxide (N2O) is the main biogenic greenhouse gas contributing to the global warming potential (GWP) of agro-ecosystems. Evaluating the impact of agriculture on climate therefore requires a capacity to predict N2O emissions in relation to environmental conditions and crop management. Biophysical models simulating the dynamics of carbon and nitrogen in agro-ecosystems have a unique potential to explore these relationships, but are fraught with high uncertainties in their parameters due to their variations over time and space. H…

Mean squared error[SDE.MCG]Environmental Sciences/Global ChangesBayesian probabilityparameter uncertainty010501 environmental sciencesAtmospheric sciences7. Clean energy01 natural sciencesEcology and Environment[ SDV.EE ] Life Sciences [q-bio]/Ecology environmentsymbols.namesake[STAT.AP] Statistics [stat]/Applications [stat.AP]Ecosystem modelgreenhouse gasesMarkov Chain Monte Carlo0105 earth and related environmental sciences2. Zero hunger[SDV.EE]Life Sciences [q-bio]/Ecology environment[STAT.AP]Statistics [stat]/Applications [stat.AP]EcologyMarkov chainnitrous oxideEcology[ STAT.AP ] Statistics [stat]/Applications [stat.AP]Global warmingMarkov chain Monte Carlo04 agricultural and veterinary sciences15. Life on land[ SDE.MCG ] Environmental Sciences/Global Changes[SDV.EE] Life Sciences [q-bio]/Ecology environment[SDE.MCG] Environmental Sciences/Global ChangesAgriculture and Soil Science13. Climate actionGreenhouse gas040103 agronomy & agriculturesymbols0401 agriculture forestry and fisheriesEnvironmental scienceProbability distributionAnimal Science and ZoologyCERES-EGCAgronomy and Crop Sciencebayesian calibration
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Entre massification et innovations : La communication de la CGT durant le Front populaire

2009

National audience; Les années 30 et le Front populaire particulièrement, marquent un tournant dans l'histoire du mouvement ouvrier où la CGT tend à redéfinir son rapport à la société, à s'affirmer en tant qu'acteur social de la nation grâce à sa représentativité nouvellement acquise dans le cadre d'une expérience unique du syndicalisme de masse et qui s'accompagne d'une attention croissante portée par la CGT à sa communication et à ses outils de diffusion. C'est dans ce contexte que nous nous proposons donc d'étudier la communication confédérée et ses principales évolutions dans le domaine des techniques et du discours. Nous aborderons tout d'abord la presse, outil traditionnel de la propag…

MediaCGT[ SHS.HIST ] Humanities and Social Sciences/History[SHS.HIST] Humanities and Social Sciences/HistoryCommunicationCinémaSyndicalismeFront populairePresse[SHS.HIST]Humanities and Social Sciences/HistoryRadio
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Diverse histories, common ground and a shared future:the education of career guidance and counselling professionals in the Nordic countries

2019

The development of education programmes in career guidance and counseling (CGC) has followed different paths among the various Nordic countries. Ten CGC programmes in Denmark, Finland, Greenland, Iceland, Norway and Sweden were evaluated against the NICE curricular model. The results show that all NICE core competences are represented in the curricula. However, there is greater focus in some programmes on developing competences for individual career guidance, than on developing competences for working at organisational and societal levels. Implications for the cooperation and professionalisation of CGC within the Nordic countries are discussed as well as limitations of the NICE model. Keywo…

Medical educationVisual Arts and Performing Arts05 social sciencesammatinvalinnanohjausNICE competence modelCommon groundCareer guidance counselling professionalskoulutusohjelmatcareer guidance counselling professionalsEducationPeer review050106 general psychology & cognitive sciencesVocational education0502 economics and businessohjaus (neuvonta ja opastus)0501 psychology and cognitive sciencesSociology050203 business & managementCareer counselingCGC education programmes
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The late Hauterivian Faraoni "Oceanic Anoxic Event" at Río Argos (southern Spain): an assessment on the level of oxygen depletion.

2013

14 pages; International audience; An integrated study of multiple geochemical proxies (TOC, δ13Ccarb, trace metallic elements, iron speciation) on the late Hauterivian Faraoni Oceanic Anoxic Event has been performed along the hemi-pelagic section of Río Argos (south-eastern Spain) in order to better constrain the environmental perturbations linked to this event in the Subbetic domain. In the studied section, the TOC is relatively low (b0.5 wt.%) except for one sample at the base of the Faraoni horizon, where it reaches 1.5 wt.%. The δ13Ccarb signal is characterized by a minor long-term increase, primarily attributed to an enhanced organic matter burial. However, both organic and isotopic si…

Mediterranean climate010504 meteorology & atmospheric sciences[SDE.MCG]Environmental Sciences/Global ChangesIron cycle010502 geochemistry & geophysics[ SDU.STU.ST ] Sciences of the Universe [physics]/Earth Sciences/Stratigraphy01 natural sciencesLate HauterivianCarbon cyclePaleontologyIron cycleGeochemistry and Petrology[SDU.STU.GC]Sciences of the Universe [physics]/Earth Sciences/GeochemistryFaraoni EventOrganic matter0105 earth and related environmental scienceschemistry.chemical_classificationHorizon (archaeology)GeologyCarbon cycle[ SDU.STU.GC ] Sciences of the Universe [physics]/Earth Sciences/GeochemistryAnoxic watersOAEDiagenesis[ SDE.MCG ] Environmental Sciences/Global ChangeschemistryProductivity (ecology)Oxygen concentration variations[SDU.STU.ST]Sciences of the Universe [physics]/Earth Sciences/StratigraphyGeology
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Holocene climate variability of the Western Mediterranean: Surface water dynamics inferred from calcareous plankton assemblages

2020

A high-resolution study (centennial scale) has been performed on the calcareous plankton assemblage of the Holocene portion of the Ocean Drilling Program Site 976 (Alboran Sea) with the aim to identify the main changes in the surface water dynamic. The dataset also provided a seasonal foraminiferal sea surface water temperatures (SSTs), estimated using the modern analog technique SIMMAX 28, and it was compared with available geochemical and pollen data at the site. Three main climate shifts were identified as (1) the increase in abundance of Syracosphaera spp. and Turborotalita quinqueloba marks the early Holocene humid phase, during maximum summer insolation and enhanced river runoff. It i…

Mediterranean climate010506 paleontologyArcheology010504 meteorology & atmospheric sciencesPaleoclimate[SHS.ARCHEO]Humanities and Social Sciences/Archaeology and Prehistorymillennial–centennial-scale climate variability[SDE.MCG]Environmental Sciences/Global ChangesPhysical Geography; GeologyForaminifera01 natural sciencesForaminiferaPaleoclimatologyCoccolithophorescoccolithophore14. Life underwaterComputingMilieux_MISCELLANEOUSHolocene0105 earth and related environmental sciencesEarth-Surface ProcessesGlobal and Planetary ChangeEcologybiologyHoloceneMillennial-centennial-scale climate variabilityPaleontologyDrilling15. Life on landPlanktonbiology.organism_classificationAlboran SeaOceanography13. Climate actionMillennial-centennial scale climate variability[SDU.STU.PG]Sciences of the Universe [physics]/Earth Sciences/PaleontologySurface waterCalcareousGeologyPaleoproductivity
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The Grotta Grande of Scario (Salerno, Italy): Archaeology and environment during the last interglacial (MIS 5) of the Mediterranean region

2011

Abstract Archeological and paleo-environmental researches carried on the Grotta Grande site illustrate the importance of a multidisciplinary approach among archeologists, palynologists and paleontologists. The archaeology, fauna, pollen and micro-charcoal recovered in two short sedimentary successions (trenches A, F) located close to the entrance of the cave are discussed. The cave opens directly on the Tyrrhenian Sea, 2 km from Scario (Salerno, Campania, Southern Italy). The morphology of the cave and sedimentary processes were controlled by eustatic fluctuations during the late Middle Pleistocene and the early Late Pleistocene. The sea repeatedly occupied the cave. The cave was frequented…

Mediterranean climatePalinologyPleistoceneGrotta Grande (Scario)FaunamammalFaunal and pollen remainsLast InterglacialMiddle Palaeolithic; Southern Italy; Faunal and pollen remains; Grotta GrandePaleontologyCaveMiddle PalaeolithicGlacial periodfaunaEarth-Surface ProcessesPalynologygeographygeography.geographical_feature_categorybiologyarchaeologyGrotta GrandeSettore GEO/01 - Paleontologia E Paleoecologiabiology.organism_classificationArchaeologyArcgaeologyStraight-tusked elephantItalyInterglacialSouthern ItalyenvironmentGeologyGrotta Grande (Scario); archaeology; fauna; pollen and micro-charcoalpollen and micro-charcoalQuaternary International
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Zonation by ammonites and foraminifers of the Vraconnian-Turonian interval: A comparison of the Boreal and Tethyan domains (NW Europe / Central Tunis…

2008

International audience; Since the end of the 19th century the interval comprising the uppermost Upper Albian, the Cenomamian, the Turonian and the basal Coniacian has been subdivided, first into ammonite zones, then, beginning in the middle of the 20th century, into zones of planktonic foraminifera. These two groups, one macrofossil, the other microfossil, are particularly effective for bio-chronostratigraphy thanks to their rapid rates of evolution. But differences in the faunal makeup between the Boreal domain (northwestern Europe) and the Tethyan domain (Mediterranean) have for a long time hindered precise correlation of the two domains. Today, in a time interval covering about 16 millio…

Mediterranean climateStratigraphyzones[ SDU.STU.ST ] Sciences of the Universe [physics]/Earth Sciences/Stratigraphy[SDE.MCG.CPE] Environmental Sciences/Global Changes/domain_sde.mcg.cpe[ SDE.MCG.CPE ] Environmental Sciences/Global Changes/domain_sde.mcg.cpeCretaceousForaminiferaPaleontologyzonationlcsh:Stratigraphy[SDU.STU.GC] Sciences of the Universe [physics]/Earth Sciences/GeochemistryCenomanianTethyslcsh:QE701-760lcsh:QE640-699Ammoniteammonitesbiologylcsh:QE1-996.5PaleontologyMacrofossilGeologyVraconnianAlbianTuronianbiology.organism_classification[ SDU.STU.GC ] Sciences of the Universe [physics]/Earth Sciences/Geochemistrylanguage.human_languageCretaceouslcsh:GeologyBoreallcsh:Paleontologylanguage[SDU.STU.ST] Sciences of the Universe [physics]/Earth Sciences/StratigraphyforaminifersCenomanianGeologyCarnets de Géologie
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