Search results for "Chambers"
showing 10 items of 59 documents
Performance study of a 3×1×1 m3 dual phase liquid Argon Time Projection Chamber exposed to cosmic rays
2021
We report the results of the analyses of the cosmic ray data collected with a 4 tonne (3×1×1 m3) active mass (volume) Liquid Argon Time-Projection Chamber (TPC) operated in a dual-phase mode. We present a detailed study of the TPC's response, its main detector parameters and performance. The results are important for the understanding and further developments of the dual-phase technology, thanks to the verification of key aspects, such as the extraction of electrons from liquid to gas and their amplification through the entire one square metre readout plain, gain stability, purity and charge sharing between readout views. peerReviewed
Effect of the surface charge of liposomes on their uptake by angiogenic tumor vessels
2003
Recently, cationic liposomes have been shown to preferentially target the angiogenic endothelium of tumors. It was the aim of our study to investigate the influence of liposomal surface charge on the uptake and kinetics of liposomes into solid tumors and tumor vasculature. Experiments were performed in the amelanotic hamster melanoma A-Mel-3 growing in the dorsal skinfold chamber preparation of male Syrian golden hamsters. Fluorescently labeled liposomes with different surface charge were prepared. Accumulation of i.v. injected liposomes was assessed by quantitative intravital fluorescence microscopy of tumor and surrounding host tissue. The histological distribution of liposomes was analyz…
NEXT-100 Technical Design Report (TDR). Executive summary
2012
[EN] In this Technical Design Report (TDR) we describe the NEXT-100 detector that will search for neutrinoless double beta decay (ßß0v) in 136XE at the Laboratorio Subterráneo de Canfranc (LSC), in Spain. The document formalizes the design presented in our Conceptual Design Report (CDR): an electroluminescence time projection chamber, with separate readout planes for calorimetry and tracking, located, respectively, behind cathode and anode. The detector is designed to hold a maximum of about 150 kg of xenon at 15 bar, or 100 kg at 10 bar. This option builds in the capability to increase the total isotope mass by 50% while keeping the operating pressure at a manageable level. The readout pla…
Design and characterization of the SiPM tracking system of NEXT-DEMO, a demonstrator prototype of the NEXT-100 experiment
2013
NEXT-100 experiment aims at searching the neutrinoless double-beta decay of the Xe-136 isotope using a TPC filled with a 100 kg of high-pressure gaseous xenon, with 90% isotopic enrichment. The experiment will take place at the Laboratorio Subterraneo de Canfranc (LSC), Spain. NEXT-100 uses electroluminescence (EL) technology for energy measurement with a resolution better than 1% FWHM. The gaseous xenon in the TPC additionally allows the tracks of the two beta particles to be recorded, which are expected to have a length of up to 30 cm at 10 bar pressure. The ability to record the topological signature of the beta beta 0 nu events provides a powerful background rejection factor for the bet…
The Next White (NEW) detector
2018
[EN] Conceived to host 5 kg of xenón at a pressure of 15 bar in the ¿ducial volume,the NEXTWhite (NEW)apparatus is currently the largest high pressure xenon gas TPC using electroluminescent ampli¿cation in the world. It is also a 1:2 scale model of the NEXT-100 detector scheduled to start searching for ßß0¿ decays in 136Xe in 2019. Both detectors measure the energy of the event using a plane of photomultipliers located behind a transparent cathode. They can also reconstruct the trajectories of charged tracks in the dense gas of the TPC with the help of a plane of silicon photomultipliers located behind the anode. A sophisticated gas system, common to both detectors, allows the high gas puri…
First results on ProtoDUNE-SP liquid argon time projection chamber performance from a beam test at the CERN Neutrino Platform
2020
The ProtoDUNE-SP detector was constructed and operated on the CERN Neutrino Platform. We thank the CERN management for providing the infrastructure for this experiment and gratefully acknowledge the support of the CERN EP, BE, TE, EN, IT and IPT Departments for NP04/ProtoDUNE-SP. This documentwas prepared by theDUNEcollaboration using the resources of the Fermi National Accelerator Laboratory (Fermilab), a U.S. Department of Energy, Office of Science, HEP User Facility. Fermilab is managed by Fermi Research Alliance, LLC (FRA), acting under Contract No. DE-AC02-07CH11359. This work was supported by CNPq, FAPERJ, FAPEG and FAPESP, Brazil; CFI, IPP and NSERC, Canada; CERN; MSMT, Czech Republi…
Particle tracking in kaon electroproduction with cathode-charge sampling in multi-wire proportional chambers
2011
Abstract Wire chambers are routinely operated as tracking detectors in magnetic spectrometers at high-intensity continuous electron beams. Especially in experiments studying reactions with small cross-sections the reaction yield is limited by the background rate in the chambers. One way to determine the track of a charged particle through a multi-wire proportional chamber (MWPC) is the measurement of the charge distribution induced on its cathodes. In practical applications of this read-out method, the algorithm to relate the measured charge distribution to the avalanche position is an important factor for the achievable position resolution and for the track reconstruction efficiency. An al…
Long-term monitoring of the TeV emission from Mrk 421 with the ARGO-YBJ experiment
2011
ARGO-YBJ is an air shower detector array with a fully covered layer of resistive plate chambers. It is operated with a high duty cycle and a large field of view. It continuously monitors the northern sky at energies above 0.3 TeV. In this paper, we report a long-term monitoring of Mrk 421 over the period from 2007 November to 2010 February. This source was observed by the satellite-borne experiments Rossi X-ray Timing Explorer and Swift in the X-ray band. Mrk 421 was especially active in the first half of 2008. Many flares are observed in both X-ray and gamma-ray bands simultaneously. The gamma-ray flux observed by ARGO-YBJ has a clear correlation with the X-ray flux. No lag between the X-r…
Evaluation of Galantamine transbuccal absorption by reconstituted human oral epithelium and porcine tissue as buccal mucosa models: Part I
2008
Over the last decade, interest in delivering drugs through buccal mucosa has increased. As a major limitation in buccal drug delivery could be the low permeability of the epithelium, the aim of this study was to evaluate the aptitude of galantamine, useful in Alzheimer's disease, to penetrate the buccal mucosa. The evaluation of the ability of galantamine to permeate through the buccal epithelium was investigated using two permeation models. Firstly, in vitro permeation experiments were carried out using reconstituted human oral non-keratinised epithelium and Transwell diffusion cells system. Results were validated by ex vivo experiments using porcine buccal mucosa as membrane and Franz typ…