Search results for "Change"
showing 10 items of 6163 documents
La spécialisation des productions et les spécialistes: Une introduction
2018
With the emergence of manufacturing based economies, specialised productions take on new dimensions during the Neolithic. Production networks progressively develop during the Neolithic and the Metal Ages and can be characterised according to their scale, how they are organised, the status of producers and the intensification of the trade of manufactured goods. This results on the one hand in mass production and on the other in the creation of highly technical objects on demand within a complex economic system of consumption and exchange. This is not seen as a linear progression but as a diversification of productions, products and know-how, the chronological and social contextualisation of …
La spécialisation des productions et les spécialistes : Session XXXIV-2 du XVIIIe congrès de l'UISPP
2020
With the emergence of manufacturing based economies, specialised productions take on new dimensions during the Neolithic. Production networks progressively develop during the Neolithic and the Metal Ages and can be characterised according to their scale, how they are organised, the status of producers and the intensification of the trade of manufactured goods. This results on the one hand in mass production and on the other in the creation of highly technical objects on demand within a complex economic system of consumption and exchange. This is not seen as a linear progression but as a diversification of productions, products and know-how, the chronological and social contextualisation of …
N,N-Dimethyl-N-propylpropan-1-aminium chloride monohydrate
2008
The title compound, C8H20N+·Cl−·H2O, has been prepared by a simple one-pot synthesis route followed by anion exchange using resin. In the crystal structure, the cations are packed in such a way that channels exist parallel to the b axis. These channels are filled by the anions and water molecules, which interact via O—H...Cl hydrogen bonds [O...Cl = 3.285 (3) and 3.239 (3) Å] to form helical chains. The cations are involved in weak intermolecular C—H...Cl and C—H...O hydrogen bonds. The title compound is not isomorphous with the bromo or iodo analogues.
Tenapanor for the treatment of irritable bowel syndrome with constipation.
2020
Introduction: Irritable bowel syndrome with constipation is associated with higher rates of functional impairment, as compared to other subtypes of the syndrome. Conventional laxative-based pharmacologic therapy of IBS-C, which is mostly symptom-based, is often unsatisfactory. Tenapanor represents a first-in-class orally available inhibitor of NHE3, which is minimally absorbed in the GI tract, what constitutes a significant therapeutic benefit, as it may act on the drug target. Areas covered: Aim of this article is to sum up the evidences about pharmacodynamics and pharmacokinetics of tenapanor, focusing on animal models and in vitro studies, but also discuss clinical trials on tenapanor's …
Toward a contextualized understanding of inside sales: the role of sales development in effective lead funnel management
2022
Purpose The purpose of this study is to provide a contextualized understanding of how business-to-business (B2B) firms use the sales development function for efficient and effective lead funnel management. Design/methodology/approach The authors adopted a qualitative field-study approach and interviewed 13 people from eight firms. While software as a service (SaaS) firms are the most prevalent application context for the sales development function, the authors also included respondents from non-SaaS firms to develop an in-depth understanding of the contextualized nature of the sales development process. Findings Sales development processes can be applied in outbound prospect-focused, outbo…
Warming temperatures and ectoparasitic sea lice impair internal organs in juvenile Atlantic salmon
2021
As a consequence of climate change and open net-pen salmon farming, wild Atlantic salmon Salmo salar are increasingly likely to encounter elevated temperatures and parasite abundances during their early marine migration. Such stressors can compromise fitness by diminishing liver energy stores and impairing cardiac muscle. To assess whether temperature and infestation by salmon lice Lepeophtheirus salmonis are important correlates of liver energy stores and cardiac muscle performance in juvenile salmon, we experimentally infested fish at 3 abundances of louse infestation (zero, low, and high) and 5 temperatures (10, 13, 16, 19, and 22°C). At the end of the experiment (i.e. when sea lice reac…
Organizational social entrepreneurship : scale development and validation
2019
Purpose: Social entrepreneurship has become a growing field of research interest. Yet, past research has been held back by the lack of a rigorous measurement instrument. Rather than defining social entrepreneurship as an organizational form that a venture does or does not have, this paper agrees with Dees and Anderson (2006) that the construct is better thought of as a set of practices, processes and behaviors that organizations can engage in to a higher or a lesser degree. In other words, the construct is a set of behaviors that any organization can engage in. The purpose of the paper is to develop scale items to measure the construct of organizational social entrepreneurship (OSE). Design…
A Changing Media Landscape. Science, the Public and the Press: The Case of Climate Change
2013
Economic restructuring in the media industry has eliminated many professional journalists’ jobs, reductions that may have been hardest on specialized journalists reporting areas like science, technology, economics, or international affairs. This makes audiences even more dependent on new, often social, media for scientific information. The concept of «critical science literacy» is introduced as a way to capture the skills needed to navigate science news in the evolving media landscape. While these same skills were needed to make sense of science in the «old» media world as well, the contemporary shift resulting in attenuation of authoritative journalistic voices is likely to continue, deman…
Effect of temperature rising and ocean acidification on reproductive success of thermophilic sea urchin Arbacia lixula
2012
Bean goose migration shows a long-term temporal shift to earlier spring, but not to later autumn migration in Finland
2023
Ilmastonmuutos vaatii eliöitä mukauttamaan perinnöllisiä tai opittuja käyttäytymismallejaan muuttuviin ympäristöolosuhteisiin. Erityisen alttiita muutoksille voi olla erilaisten habitaattien välillä muuttavat linnut, joiden selviytyminen on yhteydessä muuton onnistuneeseen ajoittamiseen. Tässä tutkimuksessa käytimme metsähanhesta (Anser fabalis) avoimeen lintutietopalveluun, Tiiraan (tiira.fi – BirdLife Suomi), kerättyjä havaintoja selvittääksemme, onko lajin muuton ajoituksessa tapahtunut muutosta viimeisten 40 vuoden aikana. Lisäksi selvitimme ajoituksen yhteyttä muuton aikaiseen suursäätilaan käyttämällä Pohjois-Atlantin suursäätilaa kuvaavaa NAO-indeksiä. Tutkitulla ajanjaksolla 1978–20…