Search results for "Change"

showing 10 items of 6163 documents

Modelling Systemic Cojumps with Hawkes Factor Models

2013

Instabilities in the price dynamics of a large number of financial assets are a clear sign of systemic events. By investigating a set of 20 high cap stocks traded at the Italian Stock Exchange, we find that there is a large number of high frequency cojumps. We show that the dynamics of these jumps is described neither by a multivariate Poisson nor by a multivariate Hawkes model. We introduce a Hawkes one factor model which is able to capture simultaneously the time clustering of jumps and the high synchronization of jumps across assets.

symbols.namesakeMultivariate statisticsStock exchangeEconometricssymbolsEconomicsPoisson distributionSynchronizationTime clusteringFactor analysisSign (mathematics)SSRN Electronic Journal
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ChemInform Abstract: Magnetic Exchange Between Metal Ions with Unquenched Orbital Angular Momenta: Basic Concepts and Relevance to Molecular Magnetism

2010

This review article is a first attempt to give a systematic and comprehensive description (in the framework of the unified theoretical approach) of the exchange interactions in polynuclear systems based on orbitally degenerate metal ions in the context of their relevance to the modern molecular magnetism. Interest in these systems is related to the fundamental problems of magnetism and at the same time steered by a number of impressive potential applications of molecular magnets, like high-density memory storage units, nanoscale qubits, spintronics and photoswitchable devices. In the presence of orbital degeneracy, the conventional spin Hamiltonian (Heisenberg–Dirac–van Vleck model) becomes…

symbols.namesakeTheoretical physicsSpintronicsMagnetismChemistryQubitExchange interactionDegenerate energy levelssymbolsContext (language use)General MedicineHamiltonian (quantum mechanics)Degeneracy (mathematics)ChemInform
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Synthesis and Structure-Affinity Relationships of Spirocyclic Benzopyrans with Exocyclic Amino Moiety

2019

σ1 and/or σ2 receptors play a crucial role in pathological conditions such as pain, neurodegenerative disorders, and cancer. A set of spirocyclic cyclohexanes with diverse O-heterocycles and amino moieties (general structure III) was prepared and pharmacologically evaluated. In structure-activity relationships studies, the σ1 receptor affinity and σ1:σ2 selectivity were correlated with the stereochemistry, the kind and substitution pattern of the O-heterocycle, and the substituents at the exocyclic amino moiety. cis-configured 2-benzopyran cis-11b bearing a methoxy group and a tertiary cyclohexylmethylamino moiety showed the highest σ1 affinity ( Ki = 1.9 nM) of this series of compounds. In…

synthesisexocyclic amino moietyReceptors Opioid mudocking studieCrystallography X-RayLigands01 natural sciencesopioid receptorschemistry.chemical_compoundProtein structureDrug DiscoveryMoiety0303 health sciencesσ1 receptor ligandsstructure (σ1) affinity relationshipmolecular dynamicBenzyl groupMolecular MedicinesynthesiBenzopyransSelectivityHydrophobic and Hydrophilic Interactionsfree binding enthalpyStereochemistrychange of receptor profileMolecular Dynamics Simulation03 medical and health sciencesStructure-Activity Relationshipσ1 receptor ligands; spirocyclic compounds; benzopyrans; benzofurans; exocyclic amino moiety; synthesis; structure (σ1) affinity relationships; σ1 antagonistic activity; receptor selectivity; molecular dynamics; docking studies; free binding enthalpy; X-ray crystal structure; opioid receptors; MOR affinity; change of receptor profile; structure MOR affinity relationshipsstructure (σ1) affinity relationshipsStructure–activity relationshipHumansReceptors sigmaBenzopyransSpiro Compoundsspirocyclic compoundBinding siteMOR affinity030304 developmental biologybenzopyranbenzofuransσ1 receptor ligandBinding Sitesspirocyclic compoundsreceptor selectivitystructure MOR affinity relationshipsdocking studiesbenzofuranopioid receptorX-ray crystal structuremolecular dynamics0104 chemical sciencesProtein Structure Tertiary010404 medicinal & biomolecular chemistrychemistrySalt bridgeσ1 antagonistic activity
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The Dynamics of the Organizational Culture in a Municipality

2013

system dynamichuman resource managementorganizational cultureorganizational dynamicchange managementwork and organizational psychology
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Timing the information system upgrade

2010

A system upgrade requires careful planning as its implications to organizational systems might be enormous. Although in IS literature the requirements and process of systems upgrade have been discussed, the timing when to upgrade and what factors guide it has been of lesser interest. Consequently, in this paper we focus on information systems upgrading and its timing from the perspective of the user organization. Upgrading is enabled by the availability of a new software version. When to upgrade, meanwhile, is determined by the business interests of the customer organization, business calendar, development projects, and the vendor. These factors were identified by interviewing 14 IT manager…

system upgrade timingdeterminantitmotivesvendorcustomerajoitus (suunnittelu)Version changeupgradeinformation systems
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Transitions en système

2020

Cette illustration conçue par l'auteur et co-réalisée avec l'association Alterre Bourgogne-Franche-Comté vise à synthétiser le concept de la Transition, fonctionnant comme un système, où chaque élément est lié aux autres, de telle sorte qu'on ne peut efficacement concevoir une banche de transition sans structurer les autres dans une même dynamique.Cette modélisation est issue de travaux de recherche de l'auteur qui sont en cours de publication (sur 2022 et 2023) dans le cadre de l'Observatoire de la Transition Socio-Écologique (MSHE C. N. Ledoux, Université de Franche-Comté et CNRS, Université de Bourgogne), et dans le cadre d'une Habilitation à Diriger les Recherches en cours.

systèmeaccompagnement au changementtransition[SHS.INFO] Humanities and Social Sciences/Library and information sciences
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Caractérisation et diagenèse thermique des roches mères pétrolières de la série des Schistes d'âge néocomien moyen-barrémien dans le bassin intérieur…

2006

8 pages; International audience

série des Schistes[SDE.MCG]Environmental Sciences/Global Changesbassin intérieur[ SDU.STU.ST ] Sciences of the Universe [physics]/Earth Sciences/Stratigraphy[ SDU.STU.GC ] Sciences of the Universe [physics]/Earth Sciences/Geochemistry[SDE.MCG.CPE]Environmental Sciences/Global Changes/domain_sde.mcg.cpeNéocomien[SDE.MCG.CPE] Environmental Sciences/Global Changes/domain_sde.mcg.cpe[ SDE.MCG.CPE ] Environmental Sciences/Global Changes/domain_sde.mcg.cpe[ SDE.MCG ] Environmental Sciences/Global Changes[SDE.MCG] Environmental Sciences/Global Changes[SDU.STU.GC]Sciences of the Universe [physics]/Earth Sciences/Geochemistry[SDU.STU.ST]Sciences of the Universe [physics]/Earth Sciences/Stratigraphymatière organiquegéochimie organique[SDU.STU.GC] Sciences of the Universe [physics]/Earth Sciences/Geochemistry[SDU.STU.ST] Sciences of the Universe [physics]/Earth Sciences/StratigraphyBarrémienGabonComputingMilieux_MISCELLANEOUS
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Rehearsing to control depressive symptoms through a behavior change support system

2013

Depressive symptoms are generally coupled with distress and high treatment costs. We present our on-going research on a Web-based behavior change support system, which utilizes Acceptance and Commitment Therapy as a rehearsal tool. We present a summarized account of the research setting, studied persuasive software features, and a brief account of initial data analysis. Our work presents implications on design interventions for mental well-being and human-computer interaction.

ta113DistressPsychotherapistWork (electrical)Control (management)Behavior changePsychological interventionRehearsingPsychologyAcceptance and commitment therapyta515Depressive symptomsCHI '13 Extended Abstracts on Human Factors in Computing Systems
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Quantile index for gradual and abrupt change detection from CFB boiler sensor data in online settings

2012

In this paper we consider the problem of online detection of gradual and abrupt changes in sensor data having high levels of noise and outliers. We propose a simple heuristic method based on the Quantile Index (QI) and study how robust this method is for detecting both gradual and abrupt changes with such data. We evaluate the performance of our method on the artificially generated and real datasets that represent different operational settings of a pilot circulating fluidized bed (CFB) reactor and CFB cold model. Our experiments suggest that QI can be used for designing very simple yet effective methods for gradual change detection in the noisy sensor data. It can be also used for detectin…

ta113Engineeringbusiness.industryOutlierBoiler (power generation)Data miningbusinesscomputer.software_genrecomputerChange detectionQuantile
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Learnings from the Finnish Game Industry

2016

The motivation behind our research was the rapid growth and business wins of world-class Finnish game companies, like Supercell, as well as the success of other game companies in Finland. In particular, Supercell's growth is something that has not been heard of before and this raised the interest to research what game companies have been doing right. Supercell is not the only Finnish success. Rovio is also well known and has the roots for success from few years before. There are also other game companies in Finland that have succeeded and this motivated us to investigate what is happening behind the game industry and what could be learned from there that could be applied to other software i…

ta113Engineeringgame industry040301 veterinary sciencesbusiness.industryStar (game theory)0402 animal and dairy scienceContext (language use)Advertising04 agricultural and veterinary sciencesPublic relations040201 dairy & animal scienceMountain sheepNewspaper0403 veterinary scienceEntertainmentcvg.developerOrder (exchange)NarrativecvgGame DeveloperbusinessFinland
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