Search results for "Childhood cancer"
showing 10 items of 90 documents
Methods of spatial cluster detection in rare childhood cancers: Benchmarking data and results from a simulation study on nephroblastoma
2021
Abstract The potential existence of spatial clusters in childhood cancer incidence is a debated topic. Identification of rare disease clusters in general may help to better understand disease etiology and develop preventive strategies against such entities. The incidence of newly diagnosed childhood malignancies under 15 years of age is 140/1,000,000. In this context, the subgroup of nephroblastoma represents an extremely rare entity with an annual incidence of 7/1,000,000. We evaluated widely used statistical approaches for spatial cluster detection in childhood cancer (Ref. [22] Schundeln et al., 2021, Cancer Epidemiology). For the simulation study, random high risk clusters of 1 to 50 ad…
Childhood cancer survival in Europe 1999-2007: results of EUROCARE-5-a population-based study.
2014
To access publisher's full text version of this article. Please click on the hyperlink in Additional Links field. Survival and cure rates for childhood cancers in Europe have greatly improved over the past 40 years and are mostly good, although not in all European countries. The EUROCARE-5 survival study estimates survival of children diagnosed with cancer between 2000 and 2007, assesses whether survival differences among European countries have changed, and investigates changes from 1999 to 2007. We analysed survival data for 157,499 children (age 0-14 years) diagnosed between Jan 1, 1978 and Dec 31, 2007. They came from 74 population-based cancer registries in 29 countries. We calculated …
A sensemaking approach to a discursive ethical skill in healthcare management: the case of an oncopaediatric service
2015
International audience; This study uses the case of an oncological paediatric service to discuss sensemaking and discourse ethics in the context of caregiving, building ethical competence to provide the best care possible to children. The patients and their families live in paediatric care, some for several years. At length, an intense relationship may develop between the medical staff and patients' family members, albeit at times a difficult relationship. Still, interviews conducted indicated that when caregivers provided the best care possible to these patients, even in this harsh environment, an ethics of sensitivity made a positive difference both for the patients and the medical staff.…
Worldwide comparison of survival from childhood leukaemia for 1995–2009, by subtype, age, and sex (CONCORD-2): a population-based study of individual…
2017
BACKGROUND: Global inequalities in access to health care are reflected in differences in cancer survival. The CONCORD programme was designed to assess worldwide differences and trends in population-based cancer survival. In this population-based study, we aimed to estimate survival inequalities globally for several subtypes of childhood leukaemia. METHODS: Cancer registries participating in CONCORD were asked to submit tumour registrations for all children aged 0-14 years who were diagnosed with leukaemia between Jan 1, 1995, and Dec 31, 2009, and followed up until Dec 31, 2009. Haematological malignancies were defined by morphology codes in the International Classification of Diseases for …
Complementary and alternative treatment methods in children with cancer. A population based retrospective survey on the prevalence of use in Germany
2008
Introduction Few studies have been conducted to date on the prevalence of use of complementary and alternative treatment methods (CAM) in paediatric oncology and those that have been conducted are often not representative. We therefore decided to study a representative sample of children with cancer in the German population. Patients and methods The study took the form of a retrospective survey amongst all parents whose children were first diagnosed with a disease covered by the German Childhood Cancer Registry in 2001. The primary objectives of the survey were to establish the prevalence of use of CAM and the factors related to its use. Results Of the 1595 questionnaires sent out, 1063 (67…
Recent epidemiological studies on ionizing radiation and childhood cancer in Germany.
1998
The results from recent epidemiological studies based on the German Childhood Cancer Registry are summarized.An oecological study covers 16 years' incidence of childhood malignancies in areas surrounding nuclear facilities and in matched control regions. Two population-based case control studies explore potential risk factors of childhood leukaemia in the state of Lower Saxony (1988 93) and in all western states of Germany (1992-94).There was no increased incidence of childhood leukaemia and other malignancies in the vicinity of nuclear installations. X-ray examinations during pregnancy and in early childhood were not associated with an increased risk of childhood leukaemia. There were no d…
Effective childhood cancer treatment: The impact of large scale clinical trials in Germany and Austria
2013
In Germany and Austria, more than 90% of pediatric cancer patients are enrolled into nationwide disease-specific first-line clinical trials or interim registries. Essential components are a pediatric cancer registry and centralized reference laboratories, imaging review, and tumor board assistance. The five-year overall survival rate in countries where such infrastructures are established has improved from 80% since 1995. Today, treatment intensity is tailored to the individual patient's risk to provide the highest chances of survival while minimizing deleterious late effects. Multicenter clinical trials are internationalized and serve as platforms for further improvements by novel drugs an…
Musculoskeletal manifestations of childhood cancer and differential diagnosis with juvenile idiopathic arthritis (ONCOREUM): a multicentre, cross-sec…
2021
Summary Background Presenting symptoms of childhood cancers might mimic those of rheumatic diseases. However, the evidence available to guide differential diagnosis remains scarce. Preventing wrong or delayed diagnosis is therefore important to avoid incorrect administration of glucocorticoid or immunosuppressive therapy and worsening of prognosis. As such, we aimed to assess the prevalence and characteristics of presenting musculoskeletal manifestations in patients at cancer onset and to identify the factors that differentiate childhood malignancies with arthropathy from juvenile idiopathic arthritis. Methods We did a multicentre, cross-sectional study at 25 paediatric haemato-oncology cen…
Pediatric Psycho-Oncology
2013
La psicooncología pediátrica, entre otras, estudia por qué el cáncer, además de ser una enfermedad crónica que amenaza la vida de quien la padece, es una enfermedad que simboliza el sufrimiento de la persona enferma y su familia. El tratamiento del cáncer infantil implica un régimen médico exigente en el que los niños y sus familias se enfrentan a múltiples factores estresantes, que provocan cambios considerables en las actividades diarias; por ejemplo, alteración de los roles familiares y sociales, temor a la adhesión al tratamiento y una constante amenaza de muerte. El presente trabajo tiene como objetivo mostrar, por medio de una revisión teórica, el papel de la psicooncología pediátrica…
Pediatric Psycho-Oncology
2013
La psicooncología pediátrica, entre otras, estudia por qué el cáncer, además de ser una enfermedad crónica que amenaza la vida de quien la padece, es una enfermedad que simboliza el sufrimiento de la persona enferma y su familia. El tratamiento del cáncer infantil implica un régimen médico exigente en el que los niños y sus familias se enfrentan a múltiples factores estresantes, que provocan cambios considerables en las actividades diarias; por ejemplo, alteración de los roles familiares y sociales, temor a la adhesión al tratamiento y una constante amenaza de muerte. El presente trabajo tiene como objetivo mostrar, por medio de una revisión teórica, el papel de la psicooncología pediátrica…