Search results for "Choledocholithiasis"

showing 5 items of 5 documents

Loss of cellular FLICE-inhibitory protein promotes acute cholestatic liver injury and inflammation from bile duct ligation.

2017

Cholestatic liver injury results from impaired bile flow or metabolism and promotes hepatic inflammation and fibrogenesis. Toxic bile acids that accumulate in cholestasis induce apoptosis and contribute to early cholestatic liver injury, which is amplified by accompanying inflammation. The aim of the current study was to evaluate the role of the antiapoptotic caspase 8-homolog cellular FLICE-inhibitory (cFLIP) protein during acute cholestatic liver injury. Transgenic mice exhibiting hepatocyte-specific deletion of cFLIP (cFLIP−/−) were used for in vivo and in vitro analysis of cholestatic liver injury using bile duct ligation (BDL) and the addition of bile acids ex vivo. Loss of cFLIP in h…

0301 basic medicineLiver CirrhosisTime FactorsPhysiologyCASP8 and FADD-Like Apoptosis Regulating ProteinInflammationApoptosisp38 Mitogen-Activated Protein KinasesHepatitisBile Acids and Salts03 medical and health sciencesNecrosisCholestasisPhysiology (medical)medicineHepatic Stellate CellsAnimalsASK1Genetic Predisposition to DiseaseLigationCells CulturedTumor Necrosis Factor alpha-Induced Protein 3chemistry.chemical_classificationLiver injuryCommon Bile DuctMice KnockoutReactive oxygen speciesHepatologyBile duct ligationGastroenterologyTranscription Factor RelAmedicine.diseaseOxidative Stress030104 developmental biologyCholedocholithiasisPhenotypechemistryLiverNeutrophil InfiltrationApoptosisFLICE Inhibitory ProteinCancer researchHepatocytesCytokinesmedicine.symptomInflammation MediatorsSignal TransductionAmerican journal of physiology. Gastrointestinal and liver physiology
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Double-balloon endoscopy for retrograde cholangiography in patients with choledochojejunostomy and Roux-en-Y reconstruction.

2009

BACKGROUND Choledochojejunal anastomoses with Roux-en-Y reconstruction excludes the biliary tract from conventional endoscopic retrograde cholangiography (ERC) with standard endoscopes due to the length of the interposed small bowel segment. Double-balloon enteroscopy (DBE) facilitates deep insertion into the small bowel and may be used to perform ERC in these patients. In the present case series we report our experience with diagnostic and therapeutic double-balloon ERC in patients with choledochojejunostomy to a long Roux-en-Y loop previously unavailable for standard length endoscopes. PATIENTS AND METHODS Between December 2004 and May 2008 15 patients (mean age: 60.2 years) with choledoc…

EnteroscopyAdultMalemedicine.medical_specialtyTime FactorsCholangitisAnastomosisCholangiographyCholestasisMedicineHumansIn patientDouble balloon endoscopyAgedAged 80 and overCholestasismedicine.diagnostic_testbusiness.industryGastroenterologyAnastomosis Roux-en-YEndoscopyMiddle Agedmedicine.diseaseRoux-en-Y anastomosisSurgeryCholedocholithiasisTreatment OutcomeBiliary tractCholedochostomyFemaleRadiologybusinessCholangiographyFollow-Up StudiesZeitschrift fur Gastroenterologie
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Endoscopic papillary large balloon dilation in patients with large biliary stones and periampullary diverticula: Results of a multicentric series.

2018

Abstract Introduction Stone extraction represents the most frequent indication for endoscopic retrograde cholangiopancreatography (ERCP). Endoscopic papillary large balloon dilation (EPLBD) is a recent introduced approach consisting of an endoscopic papillary large balloon dilation following limited endoscopic sphyncterotomy (ES), which has been proven to be safe and effective for extraction of large common bile duct (CBD) stones. Peri-ampullary diverticula (PAD) are described in 10–20% of patients undergoing ERCP. Aim of our study is to evaluate efficacy and safety of EPLBD for the extraction of large biliary stones in patients with PAD. Methods The prospectively collected endoscopy databa…

Malemedicine.medical_specialtyAmpulla of VaterDilation assisted stone extractionTherapeutic ERCPEndoscopic papillary large balloon dilationGallstonesDASE Dilation assisted stone extraction Difficult choledocholithiasis03 medical and health sciencesSphincterotomy Endoscopic0302 clinical medicineInternal medicinemedicineStone extractionHumansLarge bile duct stoneIn patientAgedRetrospective StudiesAged 80 and overCholangiopancreatography Endoscopic RetrogradeEndoscopic retrograde cholangiopancreatographyHepatologyCommon bile ductmedicine.diagnostic_testbusiness.industryGastroenterologyDASEHepatologyMiddle AgedDilatationSurgeryEndoscopyDiverticulummedicine.anatomical_structureLogistic ModelsTreatment OutcomeItalyDifficult choledocholithiasi030220 oncology & carcinogenesisBalloon dilation030211 gastroenterology & hepatologyFemaleEPLBDbusinessBILIARY STONESDigestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver
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Efficacy and safety of direct transnasal cholangioscopy with standard ultraslim endoscopes: results of a large cohort study.

2013

Background Direct cholangioscopy (DC) with ultraslim endoscopes and free-hand cannulation of the common bile duct (CBD) is a promising technique for evaluating and treating cholangiopathy. However, its safety and success rates are as yet unclear. Objective To evaluate the overall success rates and adverse events with the procedure. Design Single-center, prospective cohort study; 12 patients retrospectively enrolled. Setting Academic tertiary referral center. Patients A total of 100 DC procedures in 84 patients with biliary disease were evaluated prospectively. Interventions DC performed with the patient under conscious sedation. Main Outcome Measurements Overall success rates and adverse ev…

Malemedicine.medical_specialtySedationOperative TimeConscious SedationNoseBalloonBiliary diseaseCholangiocarcinomamedicineHumansRadiology Nuclear Medicine and imagingEndoscopy Digestive SystemProspective StudiesProspective cohort studyAdverse effectAgedAged 80 and overCommon bile ductbusiness.industryBile ductGastroenterologyMiddle Agedmedicine.diseaseLarge cohortSurgerymedicine.anatomical_structureBile Ducts IntrahepaticCholedocholithiasisBile Duct NeoplasmsFemalemedicine.symptombusinessGastrointestinal endoscopy
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Fragmentation of bile duct stones: a prospective systematic in vitro evaluation of argon plasma coagulation, cryotechnology, and water-jet technology

2009

Background and study aim Choledocholithiasis is a common disease in the West. Lithotripsy by mechanical methods using baskets and by laser or electrohydraulic methods varies in effectiveness. With argon plasma coagulation (APC), high temperatures are used for devitalization and fragmentation; cryogenic techniques use the selective controlled application of freeze-thaw cycles to devitalize pathological tissue; and the dissecting water jet exploits the high pressure action of a thin laminar jet. We aimed to assess the feasibility and effectiveness of APC, cryotechnology, and the dissecting water jet as options for the fragmentation of bile duct stones. Methods In an in vitro feasibility study…

medicine.medical_specialtymedicine.medical_treatmentUrologyArgon plasma coagulationGallstonesIn Vitro TechniquesLithotripsyCryosurgeryElectrocoagulationLithotripsyElectrocoagulationPressuremedicineHumansArgonFragmentation (cell biology)Jet (fluid)Bile ductbusiness.industryGastroenterologyWaterWater jetSurgeryCholedocholithiasismedicine.anatomical_structureFragmentation rateFeasibility StudiesbusinessEndoscopy
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