Search results for "Chris"

Neddylation inhibition ameliorates steatosis in NAFLD by boosting hepatic fatty acid oxidation via the DEPTOR-mTOR axis

2021

Objective Neddylation is a druggable and reversible ubiquitin-like post-translational modification upregulated in many diseases, including liver fibrosis, hepatocellular carcinoma, and more recently, non-alcoholic fatty liver disease (NAFLD). Herein, we propose to address the effects of neddylation inhibition and the underlying mechanisms in pre-clinical models of NAFLD. Methods Hepatic neddylation measured by immunohistochemical analysis and NEDD8 serum levels measured by ELISA assay were evaluated in NAFLD clinical and pre-clinical samples. The effects of neddylation inhibition by using a pharmacological small inhibitor, MLN4924, or molecular approaches were assessed in isolated mouse hep…

Poor mothers, unhealthy children: the transmission of health inequalities in the INMA study, Spain

2019

Background The health of pregnant women and their fetuses are especially sensitive to socioeconomic conditions. This study analyzes the impact of maternal socioeconomic status (SES), evaluated by occupation and maternal education level, in preterm births (PTBs) and in small for gestational age (SGA) fetuses, considering the effect of the potential mediating factors on the SES and birth outcomes. Methods A total of 2497 mother/newborn dyads from the INMA-Spain project were studied. We examined maternal occupation and education in relation to PTB and SGA along with covariate data, using logistic regression analysis. Adjusted models for each of the outcome variables in relation to SES indicato…

The international phase 4 validation study of the EORTC QLQ-SWB32: A stand-alone measure of spiritual well-being for people receiving palliative care…

2017

The EORTC Quality of Life Group has just completed the final phase (field‐testing and validation) of an international project to develop a stand‐alone measure of spiritual well‐being (SWB) for palliative cancer patients. Participants (n = 451)—from 14 countries on four continents; 54% female; 188 Christian; 50 Muslim; 156 with no religion—completed a provisional 36‐item measure of SWB plus the EORTC QLQ‐C15‐PAL (PAL), then took part in a structured debriefing interview. All items showed good score distribution across response categories. We assessed scale structure using principal component analysis and Rasch analysis, and explored construct validity, and convergent/divergent validity with …

Evidence for association between structural variants in lissencephaly-related genes and executive deficits in schizophrenia or bipolar patients from …

2008

There is evidence for an association between structural variants in genes for lissencephaly, which are involved in neuronal migration, and prefrontal cognitive deficits in schizophrenia and bipolar patients. On the basis of these intriguing findings, we analyzed 16 markers located in the lissencephaly critical region (LCR in chromosome 17p13.3) in 124 schizophrenic, 56 bipolar, and 141 healthy individuals. All recruits were from a Spanish population isolate of Basque origin that is characterized by low genetic heterogeneity. In addition, we examined whether structural genomic variations in the LCR were associated with executive cognition. Twenty-three patients (12.8%), but none of the contr…

Disclosure to God as a Mediator Between Private Prayer and Psychological Well-Being in a Christian Sample.

2021

AbstractAlthough a number of studies have reported the psychological and physical benefits of prayer, only a few have examined the means by which prayer affects health. Winkeljohn Black et al. (J Relig Health 54(2):540–553, 2015. 10.1007/s10943-014-9840-4) found disclosure to God as a mediator in the relationship between prayer and mental health. In their study, the authors used Poloma and Pendleton’s (Rev Relig Res 31(1):46–53, 1989. https://doi.org/10.2307/3511023, ) model of prayer. This study examined whether disclosure to God as a mediator can be upheld with Laird et al.’s (Int J Psychol Relig 14(4):251–272, 2004) prayer model. The study included 285 Polish adults (50.2% of women), age…

Effects of functional resistance training on fitness and quality of life in females with chronic nonspecific low-back pain.

2018

BACKGROUND: Exercise is important as adjuvant in the chronic low back pain (CLBP) treatment. Functional training could involve benefits for low back pain (LBP) patients. OBJECTIVE: To evaluate the effects of a 12-week period of functional resistance training on health-related quality of life (HRQOL), disability, body pain, and physical fitness in CLBP females. METHODS: Nineteen females CLBP were recruited according to Paris Task Force on Back Pain criteria. Participants were randomly assigned to an exercise group (EG); and a control group (CG). Subjects were tested at baseline and at week 12 after 24 sessions, 2 days per week. Body pain was assessed using visual analog scale (VAS), disabili…

Christianity in Africa : Roman Catholicism

2019

Older and Younger Adults Perform Similarly in an Iterated Trust Game

2021

This work was supported by the Spanish Ministry of Education, Culture and Sports, with pre-doctoral FPU fellowship FPU14/07106 to MT, and the Spanish Ministry of Economy and Competitiveness, with research projects PSI2014-52764-P and PSI2017-84926-P to JL. This research is part of MT’s thesis dissertation under the supervision of JL.

Profilo dell'attività scientifica di Fabiola Ardizzone

2018

Si ripercorre l'attività scientifica della compianta Collega Fabiola Ardizzone, dai suoi esordi come allieva della Cattedra di Archeologia Cristiana dell'Università di Palermo, all'attività di insegnamento e di ricerca sul campo in qualità di Professore Associato. Il contributo dato da Fabiola Ardizzone agli studi sulla Tarda Antichità e sul Medioevo siciliani hanno riguardato molteplici direttrici di ricerca: dall'identificazione di nuove classi ceramiche alle modalità di organizzazione delle aree funerarie, dai problemi di topografia urbana all'archeologia dei cimiteri e ai problemi della produzione e circolazione delle produzioni ceramiche. The paper traces the scientific activity of Fab…

La réception des Noces chimiques d'Andreae chez Novalis [in] Jean-Pierre Brach, Aurélie Choné: Un roman alchimique à Strasbourg 1616-2016. Ein al…

2018

International audience