Search results for "Cinnamaldehyde"

showing 3 items of 13 documents

STUDIES ON BICYCLO[3.3.1]NONANES FOR SYNTHESIS OF CYCLOOCTENES

2002

This paper describes a full conformational and stereochemical study of bicylo[3.3.1]nonanes, obtained from the reaction between cinnamaldehyde and 1-morpholine 1-cyclohexene. NMR data and stereochemistry were unequivocally established and assigned by two-dimensional experiments and single-crystal X-ray analysis. The crystal structure of a minor compound, 4, is reported. Cyclooctenes, which are present in natural products with biological activities, were synthesized from the bicyclononanes via the Wharton fragmentation.

chemistry.chemical_compoundBicyclic moleculeChemistryStereochemistryOrganic ChemistryCrystal structureNmr dataCinnamaldehydeSynthetic Communications
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Cinnamaldehyde Induces Expression of Efflux Pumps and Multidrug Resistance in Pseudomonas aeruginosa

2019

Essential oils or their components are increasingly used to fight bacterial infections. Cinnamaldehyde (CNA), the main constituent of cinnamon bark oil, has demonstrated interesting properties in vitro against various pathogens, including Pseudomonas aeruginosa. In the present study, we investigated the mechanisms and possible therapeutic consequences of P. aeruginosa adaptation to CNA. Exposure of P. aeruginosa PA14 to subinhibitory concentrations of CNA caused a strong albeit transient increase in the expression of operons that encode the efflux systems MexAB-OprM, MexCD-OprJ, MexEF-OprN, and MexXY/OprM. This multipump activation enhanced from 2- to 8-fold the resistance (MIC) of PA14 to …

medicine.drug_classAntibioticsMicrobial Sensitivity Testsmedicine.disease_causeCinnamaldehydeMicrobiology03 medical and health scienceschemistry.chemical_compoundAntibiotic resistanceMechanisms of ResistanceDrug Resistance Multiple BacterialOils VolatilemedicineTobramycin[CHIM]Chemical SciencesPharmacology (medical)AcroleinComputingMilieux_MISCELLANEOUS030304 developmental biologyPharmacology0303 health sciences030306 microbiologyPseudomonas aeruginosaMembrane Transport Proteins[SDV.BBM.BM]Life Sciences [q-bio]/Biochemistry Molecular Biology/Molecular biologybiochemical phenomena metabolism and nutrition[SDV.SP]Life Sciences [q-bio]/Pharmaceutical sciencesAnti-Bacterial Agents3. Good healthCiprofloxacinMultiple drug resistanceInfectious DiseaseschemistryPseudomonas aeruginosaEffluxmedicine.drug
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STABILITY AND ORGANOCATALYTIC EFFICIENCY OF N-HETEROCYCLIC CARBENES ELECTROGENERATED IN ORGANIC SOLVENTS FROM IMIDAZOLIUM IONIC LIQUIDS

2015

The kinetic of degradation of 1-butyl-3-methylimidazole-2-ylidene (selected as model N-heterocyclic carbene - NHC), generated in organic solvents by cathodic reduction of the parent 1-butyl-3- methylimidazolium salts BMIm-X, was studied by a simple voltammetric analysis. The effect of NHC degradation rate on the efficiency of an organocatalyzed reaction (the synthesis of g-butyrolactone from cinnamaldehyde and trifluoromethylacetophenone) was investigated. The nature of the solvent and of the anion X have a remarkable effect on the stability of the NHC, the bis(trifluoromethylsulfonyl) imide anion being the best for a long lasting carbene (while acetonitrile seems to be the worst solvent). …

n-heterocyclic carbinen-heterocyclic carbeneHydrogen bondanion effect; cyclic voltammetry; ionic liquid; n-heterocyclic carbene; n-heterocyclic carbine; organocatalysisGeneral Chemical EngineeringSettore CHIM/06 - Chimica Organicacyclic voltammetryCinnamaldehydeSolventchemistry.chemical_compoundchemistryOrganocatalysisPolymer chemistryIonic liquidElectrochemistryOrganic chemistryorganocatalysiscyclic voltammetry N-heterocyclic carbene organocatalysis ionic liquid anion effectImideAcetonitrileCarbeneanion effectionic liquid
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