Search results for "Cipro"
showing 10 items of 369 documents
Activity–Bioavailability balance in Oral Drug Development for a Selected Group of 6‐Fluoroquinolones
2002
Abstract A nomogram is proposed to select the best candidate in drug development studies with quinolones and is intended to substitute other possible models. The nomogram is referred to as an activity–bioavailability balance (ABB) because it includes the following two criteria: ABB= 1 / gm MIC ( drug candidate ) 1 /gm MIC ( ciprofloxacin ) · F calc \( drug candidate \) F calc ( ciproflaxacin ) . The in vitro activity of a group of 4′ N ‐alkyl‐ciprofloxacin derivatives was determined together with that of ciprofloxacin, initially against some reference strains and subsequently against 159 clinical isolates of eight selected species. The inverse of the geometric mean of the lowest concentrati…
Lipid Nanocarriers-Loaded Nanocomposite as a Suitable Platform to Release Antibacterial and Antioxidant Agents for Immediate Dental Implant Placement…
2021
Immediate implant placement is a single-stage restorative approach for missing teeth widely used to overcome the ridge remodeling process occurring after dental extractions. The success of this procedure relies on opportune osseointegration in the surrounding tissues. To support this process, a multifunctional nanocomposite, to be applied in the fresh post-extraction socket, was here designed, prepared, and characterized. This formulation consists of quercetin (QRC)-loaded nanostructured lipid carriers (NLCs) entrapped in a chitosan-based solid matrix containing ciprofloxacin (CPX). QRC-NLCs were prepared by homogenization followed by high-frequency sonication, and thereafter this dispersio…
The Bile Acid Receptor GPBAR-1 (TGR5) Modulates Integrity of Intestinal Barrier and Immune Response to Experimental Colitis
2011
Background GP-BAR1, a member G protein coupled receptor superfamily, is a cell surface bile acid-activated receptor highly expressed in the ileum and colon. In monocytes, ligation of GP-BAR1 by secondary bile acids results in a cAMP-dependent attenuation of cytokine generation. Aims To investigate the role GP-BAR1 in regulating intestinal homeostasis and inflammation-driven immune dysfunction in rodent models of colitis. Methods Colitis was induced in wild type and GP-BAR1−/− mice by DSS and TNBS administration. Potential GP-BAR1 agonists were identified by in silico screening and computational docking studies. Results GP-BAR1−/− mice develop an abnormal morphology of colonic mucous cells a…
Michalis Pierìs
2004
si presenta l'opera del poeta cipriota Michalis Pierìs, con traduzione italiana di sue poesie
Microwave-assisted chemical modification of g-C3N4 for photoinduced processes: organic degradation, hydrogen production and selective oxidation of al…
2023
g-C3N4 powders were treated by means of the microwave technique in three different aqueous and organic media (HNO3, NaOH and N,N-dimethylformamide). All powders were analyzed by XRD reveling that g-C3N4 maintains its structure. The morphology of the samples was analyzed with scanning electron microscopy, where the micrographs reveals that the modifcation occurs on the surface of the g-C3N4. The photocatalytic activity of the samples was evaluated in the degradation of ciprofoxacin, hydrogen production and for the selective partial oxidation of 4-methoxybenzylalcohol (4-MBA) to its aldehyde. The sample treated with HNO3 (C3N4-HNO3) shows the best photocatalytic performance in the degradation…
La validación del clima de justicia y de la justicia entre compañeros en un entorno real de trabajo
2016
Abstract In this study we tested the validity of justice climate and peer justice, measured as second-order constructs, in a real work setting. First, we investigated the appropriateness of aggregating first-order facets of justice climate and peer justice to work-unit level of analysis. Second, we examined the construct validity of justice climate and peer justice as two different factor structures. Third, we tested the hierarchical structure of justice climate and peer justice as second-order factors. Finally, we examined the predictive validity of second-order factors justice climate and peer justice within a nomological network composed of reciprocity with the supervisor and reciprocity…
1. Recognition And Social Ontology: An Introduction
2011
One of Hegel's big ideas is that creatures with a self-conception are the subjects of developmental processes that exhibit a distinctive structure. Call a creature 'essentially self-conscious' if what it is for itself, its self- conception, is an essential element of what it is in itself. How something that is essentially self-conscious appears to itself is part of what it really is. This chapter shows how the tripartite account of erotic awareness can be used in a natural way to build a notion of recognition that satisfies these twin philosophical constraints on the interpretation of Hegel's notion of self-consciousness in terms of recognition. Doing so it clarifies the nature of the trans…
Parabolic Subgroups of Artin Groups
1997
Abstract Let ( A , Σ) be an Artin system. For X ⊆ Σ, we denote by A X the subgroup of A generated by X . Such a group is called a parabolic subgroup of A . We reprove Van der Lek's theorem: “a parabolic subgroup of an Artin group is an Artin group.” We give an algorithm which decides whether two parabolic subgroups of an Artin group are conjugate. Let A be a finite type Artin group, and let A X be a parabolic subgroup with connected associated Coxeter graph. The quasi-centralizer of A X in A is the set of β in A such that β X β −1 = X . We prove that the commensurator of A X in A is equal to the normalizer of A X in A , and that this group is generated by A X and the quasi-centralizer of…
On the consequences of the standard polynomial
1998
The purpose of this paper is to shed some light on the polynomial identities of low degree for the n × n matrix algebra over a field of characteristic 0.Our main result is that we have found all the consequences of degree n + 2 of the standard polynomial have calculated the S n+2-character of the T-ideal generated by this polynomial.