Search results for "Clase"

Identification of a genetic signature enriching for response to ibrutinib in relapsed/refractory follicular lymphoma in the DAWN phase 2 trial.

2021

Abstract Background The single‐arm DAWN trial (NCT01779791) of ibrutinib monotherapy in patients with relapsed/refractory follicular lymphoma (FL) showed an overall response rate (ORR) of 20.9% and a median response duration of 19.4 months. This biomarker analysis of the DAWN dataset sought to determine genetic classifiers for prediction of response to ibrutinib treatment. Methods Whole exome sequencing was performed on baseline tumor samples. Potential germline variants were excluded; a custom set of 1216 cancer‐related genes was examined. Responder‐ versus nonresponder‐associated variants were identified using Fisher's exact test. Classifiers with increasing numbers of genes were created …

Psychometric properties of the interaction on supervised classes scale (ISCS)

2016

Objeto: La presente investigación se centra en la construcción y validación de una escala diseñada para evaluar la calidad de la clases dirigidas: Escala de Interacción en las Clases Dirigidas (EICD). Diseño/metodología/enfoque: Se trata de un estudio descriptivo correlacional. Para la elaboración de la escala se recurrió a tres fases diferenciadas en las que diferentes expertos evaluaron la adecuación de los ítems, finalmente se estudiaron las propiedades psicométricas de la versión final en una muestra de 314 socios (69.1% mujeres) con edades entre los 18 y los 77 con una media de 39.33 años (DT=12.25). Aportaciones y resultados: La escala presenta una validez y fiabilidad adecuadas, sien…

Relación entre la incidencia de asimetrías mandibulares y la clase esquelética y patrón facial del paciente medida sobre Cone Beam Computed Tomograph…

2019

Introducción: El propósito de este estudio fue establecer si existe una relación entre la presencia de asimetrías mandibulares y la maloclusión esquelética o patrón facial del paciente.   Material y métodos: Se realizó un estudio retrospectivo comparativo. Se analizaron imágenes de tomografía computarizada de haz cónico (CBCT) de 60 sujetos del Departamento de Ortodoncia de la Universidad de Valencia (34 mujeres, 26 hombres; edad media, 32,7 ± 11,6 años). Las exploraciones CBCT se dividieron en 3 grupos (pacientes con Clase I, Clase II y Clase III esquelética) y se determinó el patrón facial de cada paciente. Utilizando dos programas informáticos (ITK-SNAP y 3DSlicer), se realizó la segment…

p-grupos finitos

1997

In the first part, new bounds for the number of conjugacy classes of maximal length of a finite $p$-group $G$, $r(G)$, are obtained, and they are related with the length of these classes. If $r(G)=p^m-b-1$, there exists a unique normal subgroup of order $p^b$, $N_b$, which is characteristic, and structural properties of these groups are studied when $b\le 3$, by paying special attention to the relation between $N_b$, $Z(G)$ and $G$. In the second part, new bounds for the degree of commutativity of a $p$-group of maximal class are established. In Chapter 2, the bounds known for $c$ are reviewed. In Chapter 3, the reuslts obtained by Shepherd for $c_0\le 4$ are extended to $c_0\le 10$ by mean…

Entre el negocio y los derechos humanos

2008

Partial melting of metagreywacke: a calculated mineral equilibria study

2008

Greywacke occurs in most regionally metamorphosed orogenic terranes, with depositional ages from Archean to recent. It is commonly the dominant siliciclastic rock type, many times more abundant than pelite. Using calculated pseudosections in the Na2O–CaO–K2O–FeO–MgO–Al2O3–SiO2–H2O–TiO2–O system, the partial melting of metagreywacke is investigated using several natural protolith compositions that reflect the main observed compositional variations. At conditions appropriate for regional metamorphism at mid-crustal depths (6–8 kbar), high-T subsolidus assemblages are dominated by quartz, plagioclase and biotite with minor garnet, orthoamphibole, sillimanite, muscovite and/or K-feldspar (±Fe–T…

Postsynaptic NO/cGMP Increases NMDA Receptor Currents via Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels in the Hippocampus

2013

The nitric oxide (NO)/cyclic guanosine monophosphate (cGMP) signaling cascade participates in the modulation of synaptic transmission. The effects of NO are mediated by the NO-sensitive cGMP-forming guanylyl cyclases (NO-GCs), which exist in 2 isoforms with indistinguishable regulatory properties. The lack of long-term potentiation (LTP) in knock-out (KO) mice deficient in either one of the NO-GC isoforms indicates the contribution of both NO-GCs to LTP. Recently, we showed that the NO-GC1 isoform is located presynaptically in glutamatergic neurons and increases the glutamate release via hyperpolarization-activated cyclic nucleotide (HCN)-gated channels in the hippocampus. Electrophysiologi…

Zirconolite-bearing ultra-potassic veins in a mantle-xenolith from Mt. Melbourne Volcanic Field, Victoria Land, Antarctica

1991

One mantle xenolith from a basanite host of the Mt. Melbourne Volcanic Field (Ross Sea Rift) is extraordinary in containing veins filled with leucite, plagioclase, clinopyroxene, nepheline, Mg-ilmenite, apatite, titaniferous mica, and the rare mineral zirconolite. These veins show extensive reaction with the dunitic or lherzolitic host (olivine+spinel+orthopyroxene+clinopyroxene). The reaction areas contain skeletal olivine and diopside crystals, plagioclase, phlogopite, aluminous spinel and ilmenite in a fine grained groundmass of aluminous spinel, clinopyroxene, olivine, plagioclase and interstitial leucite. The vein composition estimated from modal abundances and microprobe analyses is a…

Are highly siderophile elements (PGE, Re and Au) fractionated in the upper mantle of the earth? New results on peridotites from Zabargad

2000

Abstract Seven peridotite samples from Zabargad Island (Red Sea) were analyzed for highly siderophile elements (HSE), including five platinum-group elements (PGE: Os, Ir, Ru, Rh, Pd) and Re and Au. Petrography and chemical composition of the samples had been published earlier [Kurat, G., Palme, h., Embey-Isztin, A., Touret, J., Ntaflos, T., Spettel, B., Brandstatter, F., Palme, C., Dreibus, G., Prinz, m., 1993. Petrology and geochemistry of peridotites and associated vein rocks of Zabargad Island, Red Sea, Egypt. Mineralogy and Petrology 48, 309–341]. Five samples with chemical compositions typical of upper mantle rocks, from fertile to increasingly depleted mantle (CaO: 3.39 to 0.21%), hav…

Highly siderophile element geochemistry of the Earth's mantle: new data for the Lanzo (Italy) and Ronda (Spain) orogenic peridotite bodies

2000

Abstract Nine plagioclase/spinel lherzolites from the Lanzo (Italy) and Ronda (Spain) peridotite bodies were analysed for Re, Os, Ir, Ru, Rh, Pd, and Au using a high-precision instrumental neutron activation (INA) procedure after NiS fire assay. Our data conform with previous observations that orogenic lherzolite massifs sampled domains of the subcontinental lithospheric mantle (SCLM) displaying a characteristic enrichment of Ru, Rh and Pd (i.e. the light platinum group elements; PGEs) over Os and Ir. The Pd/Ir, Rh/Ir and Ru/Ir ratios are superchondritic and very similar in both suites (2.46±0.32 vs. 2.42±0.21; 0.46±0.07 vs. 0.45±0.10; 1.99±0.14 vs. 2.25±0.25, respectively). Rhenium and gol…