Search results for "Clase"

Effects of nitric oxide donors on cardiac contractility in wild-type and myoglobin-deficient mice

2002

1. The effects of the nitric oxide (NO) donors S-nitroso-N-acetylpenicillamine (SNAP), sodium(Z)-1-(N,N-diethylamino)diazen-1-ium-1,2-diolate (DEA-NONOate), and (Z)-1-[N-(2-Aminoethyl)-N-(2-ammonioethyl)amino]diazen-1-ium-1,2-diolate (DETA-NONOate) on force of contraction (F(c)) were studied in atrial and ventricular muscle strips obtained from wild-type (WT) and myoglobin-deficient (myo(-/-)) mice. 2. SNAP slightly reduced F(c) in preparations from WT mice at concentrations above 100 microM; this effect was more pronounced in myo(-/-) mice. 3. DEA-NONOate reduced F(c) in preparations from myo(-/-) mice to a larger extent than those from WT mice. 4. DETA-NONOate reduced F(c) in preparations…

Modulation of acetylcholine release in the guinea-pig trachea by the nitric oxide donor, S-nitroso-N-acetyl-DL-penicillamine (SNAP)

2000

The effects of the nitric oxide (NO) donor S-nitroso-N-acetyl-DL-penicillamine (SNAP) and the NO synthase inhibitor L-N(G)-nitroarginine (L-NOARG) on the electrically evoked [(3)H]-acetylcholine release were studied in an epithelium-free preparation of guinea-pig trachea that had been preincubated with [(3)H]-choline. SNAP (100 and 300 microM) caused small but significant increases of the electrically evoked [(3)H]-acetylcholine release (121+/-4% and 124+/-10% of control). Resting outflow of [(3)H]-ACh was not affected by SNAP. The increase by SNAP was abolished by the specific inhibitor of soluble guanylyl cyclase, 1H-[1,2,4]oxadiazolo[4,3-alpha]quinoxalin-1-one (ODQ, 1 microM). The facili…

Explaining the phenomenon of nitrate tolerance.

2005

During the last century, nitroglycerin has been the most commonly used antiischemic and antianginal agent. Unfortunately, after continuous application, its therapeutic efficacy rapidly vanishes. Neurohormonal activation of vasoconstrictor signals and intravascular volume expansion constitute early counter-regulatory responses (pseudotolerance), whereas long-term treatment induces intrinsic vascular changes, eg, a loss of nitrovasodilator-responsiveness (vascular tolerance). This is caused by increased vascular superoxide production and a supersensitivity to vasoconstrictors secondary to a tonic activation of protein kinase C. NADPH oxidase(s) and uncoupled endothelial nitric oxide synthase …

Analyse de la planification espagnole comme processus de decision politique

1977

Salones de París / 2: El culto de la cultura

2006

Dinámicas de legitimación de la desregulación laboral en España

2021

En esta tesis problematizamos la desregulación de las relaciones laborales desde el punto de vista de los automatismos y de las predisposiciones ejercidas por los actores del mercado laboral, entre los que incluimos tanto a los agentes reguladores como a los/as trabajadores/as. Es decir, desde el sentido práctico que la acción de la desregulación adquiere en un contexto de expansión de la hegemonía neoliberal, en el que subyacen los mecanismos de dominación que se imponen al quedar ocultos bajo un lenguaje organizador de lo flexible, por el que los/as trabajadores/as, acaban por pensarse a sí mismos/as como trabajadores/as desregulados/as. Se utilizan dos enfoques teóricos complementarios y…

Immuno-electron microscopic localization of the alpha(1) and beta(1)-subunits of soluble guanylyl cyclase in the guinea pig organ of corti.

2000

Guanylyl cyclases (GC) catalyze the formation of the intracellular signal molecule cyclic GMP from GTP. For some years it has been known that the heme-containing soluble guanylyl cyclase (sGC) is stimulated by NO and NO-containing compounds. The sGC enzyme consists of two subunits (alpha(1) and beta(1)). In the present study, the alpha(1) and beta(1)-subunits were identified in the guinea pig cochlea at the electron microscopic level using a post-embedding immuno-labeling procedure. Ultrathin sections of LR White embedded specimens were incubated with various concentrations of two rabbit polyclonal antibodies to the alpha(1)- and beta(1)-subunit, respectively. The immunoreactivity was visua…

Efecto de intervenciones de psicología positiva y ejercicio físico en el bienestar y malestar psicológico de estudiantes universitarios

2019

Resumen El propósito de este estudio fue analizar el efecto de intervenciones de Psicología positiva y de ejercicio físico sobre indicadores de bienestar y malestar psicológico en estudiantes universitarios costarricenses. Se realizó una investigación cuasiexperimental, de diseño factorial (4 x 2) con mediciones pre y post, en el que 233 estudiantes universitarios (18.97 ± 2.18 años, 135 mujeres, 98 hombres) se vieron expuestos a una de cuatro diferentes condiciones: intervenciones de psicología positiva (PP), intervenciones de ejercicio físico (E), intervenciones combinadas de PP y E y control (C). Se midieron indicadores de bienestar y malestar psicológico. Las intervenciones de Psicologí…

La obstinación de los hechos

1976

Local disequilibrium of plagioclase in high-temperature shear zones of the Ivrea Zone, Italy

1995

Microstructural and chemical analysis of plagioclase in 20 superficially similar amphibolite facies ductile shear zones in metagabbors and amphibolites of the Ivrea Zone in Italy reveals significant differences in An and Ba contents. Plagioclase, which was deformed at P-T conditions lower than those of the wall rocks, occurs in the following four different microstructural situations with different chemical compositions: (i) relatively undeformed porphyroclasts, (ii) dynamically recrystallized grains and subgrains rimming the porphyroclasts, (iii) infill of microcracks cross-cutting the porphyroclasts and (iv) fine-grained recrystallized grains in the matrix of the shear zones. The differenc…