Search results for "Clase"
showing 10 items of 319 documents
Mutation Analysis Identifies GUCY2D as the Major Gene Responsible for Autosomal Dominant Progressive Cone Degeneration
2008
PURPOSE. Heterozygous mutations in the GUCY2D gene, which encodes the membrane-bound retinal guanylyl cyclase-1 protein (RetGC-1), have been shown to cause autosomal dominant inherited cone degeneration and cone–rod degeneration (adCD, adCRD). The present study was a comprehensive screening of the GUCY2D gene in 27 adCD and adCRD unrelated families of these rare disorders. METHODS. Mutation analysis was performed by direct sequencing as well as PCR and subsequent restriction length polymorphism analysis (PCR/RFLP). Haplotype analysis was performed in selected patients by using microsatellite markers. RESULTS. GUCY2D gene mutations were identified in 11 (40%) of 27 patients, and all mutation…
Four- and five-phase peridotites from a continental rift system: evidence for upper mantle uplift and cooling at the Ross Sea margin (Antarctica)
1992
Upper mantle plagioclase+spinel- and spinel-peridotite xenoliths occur in basanitic and tephritic lavas of the 2.7 my to Recent Mt. Melbourne Volcanic Field (Antarctica). This field belongs to the Cenozoic McMurdo volcanic group which is located between the deep western trough of the Ross Sea rift system and the uplifted rift shoulder of the Transantarctic Mountains. Our samples cover the transition zone between rift and shoulder. We examined texture and composition of plagioclase+spinel and normal spinel peridotites and determined temperatures and pressures of formation using the internally consistent Ca-ol/cpx and 2px-thermobarometer of Kohler and Brey (1990) and Brey and Kohler (1990). D…
Estudio comparativo de dos metodologías aplicadas para la comprensión de la música contemporánea en la educación secundaria obligatoria
2016
In this paper we try to discover which methodology is more appropriate for the comprehension of the contemporary music in the Secondary Education. For that purpose by a quasi-experiment, mixed, qualitative and quantitative, the preserved results through the application of two different methodologies have been compared: a traditional one base on the masterly class and another based in different kinds of audition. The obtained results after the didactical application on the quantitative level weren´t significant, however, on the qualitative level we could also observe that the pupils who subjected to that methodology had more advantageous results regarding to the comprehension of the contempo…
A la nación por la clase. La campaña electoral socialista de noviembre de 1933
2017
El artículo analiza la campaña electoral realizada por el Partido Socialista Obrero Español para las elecciones de noviembre del 1933. A partir de la importancia que la nueva historia sociocultural y política atribuye a los discursos en la conformación de las identidades y la acción colectiva, el artículo intenta poner de manifiesto la capital importancia que tuvo el uso de la narrativa nacional por parte del socialismo. Con ello, se trata de llamar la atención sobre una vía central en la (re)construcción y difusión social de la identidad nacional española, como los procesos de politización y el rol que el socialismo pudo jugar a tal efecto. The article deals with electoral campaign carried…
Seismic properties across an amphibolite- to greenschist-facies strain gradient (Neves area, eastern Alps, Italy): New considerations for shear zone …
2021
Abstract Detecting the presence and geometry of crustal shear zones by geophysical methods relies on our understanding of the intrinsic parameters controlling the seismic properties of these deformed rocks, over the range of pressure-temperature conditions expected in the Earth's crust. To this end, we aimed to track changes in P-wave propagation velocity (VP), anisotropy (AVP) and S-wave splitting (AVS) across a natural shear zone using experimental and electron backscatter diffraction methods. Five samples were collected across a meter-scale shear zone developed under amphibolite- to greenschist-facies in the Neves metagranodiorite (Tauern Window, Eastern Alps). With increasing strain, se…
Development of predictive retention-activity relationship models of tricyclic antidepressants by micellar liquid chromatography.
1999
The distribution of tricyclic antidepressants from plasma to brain, where these drugs exert their main clinical action, and other organs is related to transport events across the cell membranes of the different tissues. It could be expected that all the molecular features that condition the transport processes (mainly hydrophobicity and molar total charge) also control the pharmacokinetic and biochemical behavior. Micellar liquid chromatography (MLC) has been proposed to emulate in vitro the partitioning process in the biomembranes. The use of micellar solutions of Brij35 as mobile phases in reversed-phase liquid chromatography has proven to be valid to predict the biological activities of …
Wharton’s Jelly Mesenchymal Stromal Cells Support the Expansion of Cord Blood–derived CD34+Cells Mimicking a Hematopoietic Niche in a Direct Cell–cel…
2018
Wharton’s jelly mesenchymal stromal cells (WJ-MSCs) have been recently exploited as a feeder layer in coculture systems to expand umbilical cord blood–hematopoietic stem/progenitor cells (UCB-HSPCs). Here, we investigated the role of WJ-MSCs in supporting ex vivo UCB-HSPC expansion either when cultured in direct contact (DC) with WJ-MSCs or separated by a transwell system or in the presence of WJ-MSC–conditioned medium. We found, in short-term culture, a greater degree of expansion of UCB-CD34+cells in a DC system (15.7 ± 4.1-fold increase) with respect to the other conditions. Moreover, in DC, we evidenced two different CD34+cell populations (one floating and one adherent to WJ-MSCs) with …
Volume strain, strain type and flow path in a narrow shear zone
1998
This study explores the state of finite strain and changes in the mean kinematic vorticity number, grain size, whole-rock chemistry and mineralogy across an upper amphibolite-facies shear zone in a metadiorite, northern Malawi, east-central Africa. P–T conditions during shear-zone formation and deformation were approximately 700–750 °C and 5–7 kbar and are slightly less than P–T conditions for the regional peak of metamorphism. The major rock-forming minerals, plagioclase, hornblende, biotite, and quartz, were deformed by crystal-plastic processes accompanied by, except for hornblende, dynamic recrystallization. The modal abundance of all four major rock-forming minerals shows no systematic…