Search results for "Clase"
showing 10 items of 319 documents
Vida más allá del PowerPoint: Un esfuerzo por superar la presente involución tecnológica de los procesos de enseñanza-aprendizaje hacia prácticas doc…
2018
La tradicional clase magistral se ha vestido o disfrazado, en el marco de la revolución digital, con tecnología para convertirse, en la pràctica, en una versión más cara y compleja, con grandes costes para los centros de enseñanza y universidades. Sigue siendo una lectura comentada por el profesor donde el alumno no tiene un papel activo, ya que es el profesor el que se considera que tiene el conocimiento, y trabaja. Los alumnos pueden preguntar si se considera necesario, ahora el estudiante no necesita ya tomar apuntes siquiera, las diapositivas de las editoriales carecen casi de erratas… Se propone con este poster dar un salto cualitativo siguiendo metodologías del mundo anglosajón para p…
Targeting B Cell Maturation Antigen (BCMA) in Multiple Myeloma: Potential Uses of BCMA-Based Immunotherapy
2018
The approval of the first two monoclonal antibodies targeting CD38 (daratumumab) and SLAMF7 (elotuzumab) in late 2015 for treating relapsed and refractory multiple myeloma (RRMM) was a critical advance for immunotherapies for multiple myeloma (MM). Importantly, the outcome of patients continues to improve with the incorporation of this new class of agents with current MM therapies. However, both antigens are also expressed on other normal tissues including hematopoietic lineages and immune effector cells, which may limit their long-term clinical use. B cell maturation antigen (BCMA), a transmembrane glycoprotein in the tumor necrosis factor receptor superfamily 17 (TNFRSF17), is expressed a…
Blood Transfusion Management for Patients Treated With Anti-CD38 Monoclonal Antibodies
2018
Daratumumab has proven to be highly efficacious for relapsed and refractory multiple myeloma (MM) and has recently been approved in the frontline setting for MM patients ineligible for transplantation. In the future, expanded indications are possible for daratumumab and other anti-CD38 monoclonal antibodies in development. For several years, it has been recognized that these therapies interfere with blood bank testing by binding to CD38 on red blood cells and causing panagglutination on the Indirect Antiglobulin Test. This can lead to redundant testing and significant delays in patient care. Given the anticipated increase in utilization of anti-CD38 monoclonal antibodies, as well as the tra…
Corundum Anorthosites-Kyshtymites from the South Urals, Russia: A Combined Mineralogical, Geochemical, and U-Pb Zircon Geochronological Study
2019
Kyshtymites are the unique corundum-blue sapphire-bearing variety of anorthosites of debatable geological origin found in the Ilmenogorsky-Vishnevogorsky complex (IVC) in the South Urals, Russia. Their mineral association includes corundum-sapphire, plagioclase (An61&ndash
La transformación de la familia: el caso de los trabajadores del sector textil-confección valenciano.
2014
El principal objetivo del artículo es valorar la incidencia del proceso de individualización en las relaciones familiares de la clase trabajadora. Un análisis pertinente si tenemos en cuenta la importancia de la familia en la provisión de bienestar en nuestro país, la capacidad de transformación que ha demostrado tener la individualización en la concepción y gestión de los vínculos entre parientes, así como la ausencia de la clase trabajadora de las principales teorizaciones sobre este proceso. Las entrevistas en profundidad realizadas a trabajadores en el sector del textil-confección en las comarcas valencianas de l?Alcoià, el Comtat y la Vall d?Albaida permiten concluir que su concepción …
Más allá de Gramsci, lucha de clases, sindicalismo e intelectuales en el siglo XXI
2020
El precio que se paga por acceder a la llamada sociedad del capital intelectual o posindustrial, es vivir en una sociedad cada vez más entregada al corporativismo de las tecnocracias; a las cuales, las diferentes clases sociales delegan la construcción de las decisiones, y por lo tanto de estrategias. La relación entre la tecnocracia y el capital financiero es clara, altas retribuciones y participación en el valor apropiado, pero muy conflictiva.
In vivo evaluation of the interaction between the Escherichia coli IGP synthase subunits using the Bacterial Two-Hybrid system
2020
ABSTRACT Histidine biosynthesis is one of the most characterized metabolic routes for its antiquity and its central role in cellular metabolism; indeed, it represents a cross-road between nitrogen metabolism and de novo synthesis of purines. This interconnection is due to the activity of imidazole glycerol phosphate synthase, a heterodimeric enzyme constituted by the products of two his genes, hisH and hisF, encoding a glutamine amidotransferase and a cyclase, respectively. Despite their interaction was suggested by several in vitro experiments, their in vivo complex formation has not been demonstrated. On the contrary, the analysis of the entire Escherichia coli interactome performed using…
D1 receptors play a major role in the dopamine modulation of mouse ileum contractility
2010
Since the role of dopamine in the bowel motility is far from being clear, our aim was to analyse pharmacologically the effects of dopamine on mouse ileum contractility. Contractile activity of mouse ileum was examined in vitro as changes in isometric tension. Dopamine caused a concentration-dependent reduction of the spontaneous contraction amplitude of ileal muscle up to their complete disappearance. SCH-23390, D1 receptor antagonist, which per se increased basal tone and amplitude of spontaneous contractions, antagonized the responses to dopamine, whilst sulpiride or domperidone, D2 receptor antagonists, were without effects. The application of both D1 and D2 antagonists had additive effe…
Cyclic AMP-dependent and independent stimulations of ovarian steroidogenesis by brain factors in the blowfly, Phormia regina.
2000
0303-7207 doi: DOI: 10.1016/S0303-7207(00)00312-9; The involvement of cyclic-AMP (cAMP) as a potential second messenger in the neurohormonal control of ovarian steroidogenesis was investigated in the adult female blowfly Phormia regina. Individual measurements of ovarian cAMP concentrations and of ovarian biosynthesis of ecdysteroids, stimulated after a protein meal, demonstrated that steroidogenesis is preceded by a peak of cAMP in the ovaries. In vitro, ovarian steroidogenesis was stimulated by cell-permeable analogues of cAMP and by forskolin. Crude brain extracts were also able to elicit a rise of cAMP in the ovaries in vitro and the secretion of ecdysteroids into the medium: such extra…
Antiproliferative effects of drugs affecting different signalling pathways on rat and human pulmonary artery smooth muscle cells
2015
Current treatments for pulmonary arterial hypertension (PAH) include pulmonary vasodilators which may also inhibit PASMC proliferation. The aim of this study was to compare the antiproliferative effects of multiple drugs on rat and human PASMC (rPASMC and hPMASC, respectively) in vitro. rPASMCs and hPASMC were starved for 24 h, then treated with different inhibitors and incubated for 48 h in 1% foetal calf serum plus endothelin-1, 5-HT and U46619. Cell number was estimated by the MTT test. Viable cells increased by 160-180% in 48 h. Activation of the cGMP pathway with the soluble guanylyl cyclase activators riociguat and YC-1 (≤ 10 µM) or the cAMP pathway by the adenylyl cyclase activator f…