Search results for "Clero"

ANP IMUUNOLOCALITATION IN INTERNAL CAROTID ARTERY WALL OF SUBJECTS WITH AN WITHOUT ATHEROSCLEROTIC LESIONS

2008

Mortality in multiple sclerosis: a review.

2008

This work was undertaken to evaluate studies on mortality caused by multiple sclerosis (MS), to evaluate if useful inferences can be drawn from survival studies that can be applied to clinical practice. A literature search was carried out to find epidemiological studies on MS prognosis, survival, mortality and causes of death relevant to our aim. The World Health Organization (WHO) reports on worldwide cause-specific mortality were also considered. Studies were evaluated according to the duration of the follow-up study, the year of publication and the methodology used. We evaluated MS survival from a methodological point of view and considered if time trends could be drawn from study result…

Chemical gels of scleroglucan obtained by cross-linking with 1,w-dicarboxylic acids: Synthesis and characterization

2005

Chemical gels obtained by cross-linking reaction between scleroglucan and I, omega-dicarboxylic acids having a number of carbon atoms from 4 to 8 in the chain, have been prepared and characterised. The networks show properties correlated with the number of carbon atoms of the acid and with the molar ratio carboxylic acid/glucose unit of the polymer (r) employed in the cross-linking reaction. The diffusion of theophylline, chosen as model drug, through the swelled cross-linked polymers has been also investigated and it has enabled the diffusion coefficients of the drug to be calculated under different environmental conditions. The release profiles of theophylline from tablets prepared with t…

Soil solarization with biodegradabile materials and its impact on soil microbial communities.

2008

Soil solarization (SS) seems one of the most promising techniques to control soilborne pathogens, but an important limitation to the diffusion of this technique is due to the drawback regarding the disposal of the used plastic materials. A possible solution to this problem is the use of biodegradable plastics. The aim of this study was compare the impact of SS with biodegradable materials with SS with plastic film and others pest management techniques (i.e. organic matter amendment, calcium cyanamide and Dazomet fungicide application) on crop productivity, soilborne disease incidence, weed suppression, and soil chemical (total N, ammonium, nitrate, available phosphorus, organic matter, hydr…

Molecular hydrogen (H 2 ) as a potential treatment for acute and chronic fatigue

2020

Many diseases as well as acute conditions can lead to fatigue, which can be either temporary or chronic in nature. Acute fatigue develops frequently after physical exercise or after alcohol hangover, whereas microbial infections such as influenza or COVID-19 and chronic diseases like Parkinson's disease or multiple sclerosis are often associated with chronic fatigue. Oxidative stress and a resulting disturbance of mitochondrial function are likely to be common denominators for many forms of fatigue, and antioxidant treatments have been shown to be effective in alleviating the symptoms of fatigue. In this study, we review the role of reactive oxygen and nitrogen species in fatigue and the an…

Analysis of the metabolic switch induced by the spirulina peptide SP6 in high fat diet ApoE-/-mice model: A direct infusion FT-ICR-MS based approach

2021

Atherosclerosis, dyslipidemia and hypertension are comorbid diseases often found in combination. Among different pharmacological approaches the employment of natural multifunctional peptides is an attractive option as side therapy. Mass spectrometry-based metabolomics provide valuable information on metabolic changes and can be useful to elucidate peptide pharmacodynamics. In this this work we performed a preliminary investigation on the potential effect of a recently characterized Spirulina platensis peptide named SP6 (GIVAGDVTPI) on the modulation of metabolism in a high fat diet ApoE-/- mice atherosclerotic model. A direct infusion Fourier transform ion cyclotron resonance mass spectrome…

Synthetic studies on neoclerodane diterpenes from Salvia splendens: oxidative modifications of ring A.

2011

Salvinorin A (1), a neoclerodane diterpene from the hallucinogenic mint Salvia divinorum, is the only known naturally occurring non-nitrogenous and specific κ-opioid agonist. Some oxidative modifications of the A ring in the congeners of 1 isolated from Salvia splendens salviarin, splenolide B, splendidin and in the non-natural 8-epi-salviarin gave new derivatives, some of which were tested as agonists at opioid receptors. However, none of these compounds were active. The presence of the C-18, C-19 lactone could be at the origin of the observed lack of binding affinity.

The role of paraoxonase 1 (PON1) as an oxidation marker, in muscle improvement after increased beta-hydroxybutyrate (BHB) in blood, in patients with …

2020

Various studies have concluded that in multiple sclerosis (MS) metabolic changes related to energy alterations are generated at the mitochondrial level. These changes produce loss of muscle mass and lead to high levels of oxidative stress related to low levels of the enzyme Paraoxonase 1 (PON1). The ketone bodies, mainly beta-hydroxybutyrate (BHB), restore this energetic alteration by improving muscular activity. This pilot study was conducted over 4 months with 51 patients diagnosed with MS, randomly divided into: an intervention group that received an isocaloric diet of a Mediterranean origin supplemented with 60 ml of coconut oil; and a control group that received the same base diet but …

Zinc and inflammatory/immune response in aging

2007

Life-long antigenic burden determines a condition of chronic inflammation, with increased lymphocyte activation and proinflammatory cytokine production. A large number of studies have documented changes in zinc metabolism in experimental animal models of acute and chronic inflammation and in human chronic inflammatory conditions. In particular, modification of zinc plasma concentration, as well as intracellular disturbance of antioxidant intracellular pathways, has been found in aging and in some age-related diseases. Zinc deficiency is diffused in aged individuals in order to avoid meat and other high zinc content foods due to fear of cholesterol. Rather, they increase the consumption of r…

An overview of randomized controlled trials on endovascular treatment for chronic cerebrospinal venous insufficiency in multiple sclerosis patients

2021

About ten years ago it was hoped that venous angioplasty for abnormal veins, primarily the internal jugular veins, will be a much awaited treatment for multiple sclerosis. Yet, a majority of randomized clinical trials on endovascular treatment for chronic cerebrospinal venous insufficiency did not reveal clinical efficacy of these procedures in multiple sclerosis patients. Still, a detailed analysis of these trials suggests that they were poorly designed, underpowered and endovascular techniques used were often far from being optimal. Nonetheless, even considering weak points of these trials, it can be concluded that venous angioplasty should not be used as a routine treatment modality in m…