Search results for "Clero"
showing 10 items of 2052 documents
Membrane fluidity and cytosolic Ca2+ concentration of the circulating polymorphonuclear leukocytes in diabetes mellitus
2014
Improvement of the expression of upper limb muscle strength and balance in a group of patients with multiple sclerosis, through a proprioceptive reha…
2022
In multiple sclerosis (MS) patients, symptoms such as: fatigue, lack of physical energy, spasticity, difficulty in performing movements, and motor coordination disorders, and with tremors, dizziness and postural instability are among the most common complications. Cattaneo et al. (2007) studied the effects of stability training on MS patients and described it as an effective intervention in reducing falls risk, improving stability, and strength. Therefore, the present study aimed to confirm early observations by the application of a proprioceptive rehabilitation program targeting balance and strength on MS patients. 13 subjects with MS, 5 male and 8 female, volunteered in the study. A MAP h…
Effectiveness of low flow vascular lesions sclerosis with monoetanolamine: Report of six cases
2007
Vascular malformations or even hemangiomas need therapeutic intervention if they start to cause clinical symptoms or personal discomfort. Different therapeutic modalities, including cryotherapy, corticosteroids, laser therapy, sclerotherapy, surgery, and/or embolization, can be performed successfully. Sclerotherapy with monoethanolamine is a relatively simple and effective method to treat low flow vascular lesions. We presented a report of six cases of vascular malformations treated with monoethanolamine. There were 3 male and 3 female patients, with an age range of 20 to 68 years. The patients were submitted to applications according to clinical response and/or tolerability. In all cases, …
Separating the Mechanism-Based and Off-Target Actions of Cholesteryl Ester Transfer Protein Inhibitors With CETP Gene Polymorphisms
2010
Background— Cholesteryl ester transfer protein (CETP) inhibitors raise high-density lipoprotein (HDL) cholesterol, but torcetrapib, the first-in-class inhibitor tested in a large outcome trial, caused an unexpected blood pressure elevation and increased cardiovascular events. Whether the hypertensive effect resulted from CETP inhibition or an off-target action of torcetrapib has been debated. We hypothesized that common single-nucleotide polymorphisms in the CETP gene could help distinguish mechanism-based from off-target actions of CETP inhibitors to inform on the validity of CETP as a therapeutic target. Methods and Results— We compared the effect of CETP single-nucleotide polymorphisms …
Influencia de la variabilidad glucémica sobre la salud micro y macrovascular en niños y adolescentes con diabetes tipo 1
2015
INTRODUCCIÓN: La enfermedad cardiovascular precoz es la principal causa de morbi-mortalidad en el paciente diabético. Se ha demostrado que el estrés oxidativo, responsable del daño vascular, es mayor en condiciones de hiperglucemia intermitente que durante la hiperglucemia mantenida. La implicación de la variabilidad glucemia como causa de las complicaciones vasculares de la diabetes es controvertida y prácticamente no estudiada en la edad pediátrica. HIPÓTESIS: La variabilidad glucémica se relaciona en niños y adolescentes diabéticos tipo 1 con las complicaciones subclínicas macro y microvasculares. MATERIAL Y MÉTODOS: Estudio transversal, analítico y observacional realizado en la Unidad d…
Angiomyolipoma of the upper lip : case report and review of the literature
2007
Angiomyolipoma (AML) is a hamartomatous growth that usually affects the kidney. One third of patients with AML present with manifestations of tuberous sclerosis. Oral AML is rare with only 6 cases reported in the English-language literature. In the present case, AML was located in the upper lip of a 43 year-old woman. Clinically, it presented as a firm nodule, well circumscribed and measuring 1x2 cm. It was surgically excised. Histopathological analysis showed a lesion composed of an admixture of smooth muscle cells, blood vessels, and adipose tissue. The immunohistochemical study revealed positivity for vimentin, smooth muscle actin, pan specific muscle actin and desmin. CD68, CD34 and mas…
In vitro model of blood-brain barrier and application on the study of the multiple sclerosis.
2008
In vitro models of blood-brain barrier and application in the study of the multiple sclerosis
2008
Alteraciones metabólicas de la Hiperlipemia Familiar Combinada y su asociación con la obesidad abdominal y la inflamación de bajo grado
2015
La HFC es un síndrome dislipémico descrito por Goldstein et al en 1973 identificado al estudiar a jóvenes supervivientes de un infarto agudo de miocardio y a sus familias. Observaron en ellos diferentes fenotipos metabólicos y lipoproteicos, con presencia de elevaciones de los niveles de colesterol total y/o triglicéridos, junto con elevación de lipoproteínas VLDL, de LDL, o de ambas lipoproteínas. La HFC presenta el desarrollo de arteriosclerosis como la manifestación clínica responsable de la enfermedad cardiovascular típica de esta enfermedad cuya expresión final es el infarto agudo de miocardio. El comienzo de la lesión ateromatosa se produce casi siempre al inicio de la vida en los pri…
Estudio de la interacción leucocito-endotelio en niños obesos
2017
Se ha descrito que la obesidad infantil conlleva una serie de alteraciones metabólicas que pueden generar a nivel vascular una respuesta inflamatoria crónica de baja intensidad y subclínica, que podría ser la base de un proceso aterosclerótico responsable del desarrollo precoz de enfermedades cardiovasculares. Teniendo en cuenta que este tipo de respuesta se inicia con la interacción entre células leucocitarias y el endotelio, el objetivo de la presente Tesis Doctoral fue estudiar de forma directa, en un modelo experimental “in vitro”, el comportamiento de la interacción entre leucocitos y células endoteliales en muestras de sangre de niños y niñas con sobrepeso u obesidad, en comparación c…