Search results for "Clero"

European guidelines on chronic mesenteric ischaemia - joint United European Gastroenterology, European Association for Gastroenterology, Endoscopy an…

2020

Chronic mesenteric ischaemia is a severe and incapacitating disease, causing complaints of post-prandial pain, fear of eating and weight loss. Even though chronic mesenteric ischaemia may progress to acute mesenteric ischaemia, chronic mesenteric ischaemia remains an underappreciated and undertreated disease entity. Probable explanations are the lack of knowledge and awareness among physicians and the lack of a gold standard diagnostic test. The underappreciation of this disease results in diagnostic delays, underdiagnosis and undertreating of patients with chronic mesenteric ischaemia, potentially resulting in fatal acute mesenteric ischaemia. This guideline provides a comprehensive overvi…

Effect of Bariatric Surgery on Intima Media Thickness: A Systematic Review and Meta-Analysis

2022

Background: Obesity, and in particular extreme obesity, as a global health problem is an important risk factor for many diseases, including atherosclerotic cardiovascular disease (ACVD). Bariatric surgery might stop or slow atherogenesis by decreasing excessive weight in the early stages of atherogenesis, by suppressing low-grade systemic inflammation as well as by inhibiting oxidative stress and endothelial dysfunction. The aim of this meta-analysis was to provide an answer to whether bariatric surgery has a significant effect on intima-media thickness (IMT) which is a surrogate marker of early atherosclerosis and has a good correlation with atherosclerotic coronary heart disease. Methods:…

Atherosclerosis: risk assessment and the role of aiming for optimal glycaemic control in young patients with type 1 diabetes

2023

Wprowadzenie: Dzieci z cukrzycą typu 1 (type 1 diabetes mellitus – DM1) mają w porównaniu ze zdrowymi rówieśnikami podwyższone ryzyko rozwoju zaawansowanej miażdżycy oraz choroby sercowo-naczyniowej (cardiovascular disease – CVD), a niedostateczna kontrola glikemii jest najważniejszym modyfikowalnym czynnikiem ryzyka CVD w DM1. Aktualne metody oceny kontroli glikemii to ocena hemoglobiny glikowanej (HbA1c), samokontrola glikemii za pomocą glukometru (SMBG), a także stosowanie systemów ciągłego monitorowania glukozy (CGM). Do pośredniej oceny ryzyka rozwoju CVD mogą służyć badania rozszerzenia tętnicy w odpowiedzi na niedokrwienie (flow-mediated dilatation – FMD) i prędkości fali tętna (PWV)…

Czy należy rutynowo wykonywać endoskopię górnego odcinka przewodu pokarmowego przed naczyniowymi zabiegami rekonstrukcyjnymi?

2001

Badaniu poddano dwie grupy chorych z niedokrwieniem kończyn kwalifikowanych do leczenia rekonstrukcyjnego. W grupie pierwszej (300 chorych) u wszystkich pacjentów wykonano rutynową przedoperacyjną endoskopię górnego odcinka przewodu pokarmowego. W grupie drugiej (300 chorych) badanie endoskopowe wykonywano u chorych objawowych. Nadżerki lub też owrzodzenia w żołądku lub dwunastnicy stwierdzono u 81 chorych (27%) z grupy pierwszej — w 56 przypadkach bez jakichkolwiek klinicznych objawów choroby. U chorych niepoddanych badaniu endoskopowemu w okresie pooperacyjnym u 8 wystąpiło krwawienie z przewodu pokarmowego powodowane czynnym owrzodzeniem trawiennym. Dodatkowo u 4 chorych zmarłych z innyc…

Estudio de la acción proinflamatoria de Angiotensina II y su posible modulación. Papel de Angiotensina II en disfunciones endoteliales.

2002

La acumulación leucocitaria es una característica de los primeros estadios de la lesión aterosclerótica, de infarto agudo de miocardio y de enfermedades renales de diversa etiología. Receptores para Angiotensina-II (Ang-II) han sido hallados en monocitos y Ang-II puede promover la activación y adhesión de estas células. Este proceso podría desencadenar o perpetuar el daño endotelial asociado a aterosclerosis e hipertensión. Los resultados de nuestro estudio demuestran que Ang-II, a dosis subvasoconstrictoras y fisiológicas, presenta propiedades proinflamatorias in vivo a nivel agudo; en concreto, produce acumulación leucocitaria en vénulas de la microcirculación mesentérica de la rata a tra…

Frequency of Mitoxantrone related heart involvement in patients affected by Multiple Sclerosis

2010

Application of tRNS to improve Multiple Sclerosis Fatigue: a sham-controlled study

2018

Background and aims: Fatigue is one of the most common, early, and disabling symptom in Multiple Sclerosis (MS). tDCS on Dorso-Lateral Prefrontal Cortex seems to give positive results on MS fatigue. Recently, a new stimulation protocol, transcranial Random Noise Stimulation (tRNS), showed powerful facilitatory effects on motor cortex in healthy subjects and ameliorated pain in MS patients. Here we aimed to explore effects of motor cortex tRNS in MS fatigue.Methods: 13 MS fatigued patients were enrolled in a blind, sham controlled tRNS study. 7 patients received 1.5 mA, 101-640 Hz tRNS stimulation and 6 patient received sham stimulation, both stimulations applied daily over M1 for 15 minutes…

Positive or negative involvement of heat-shock proteins in multiple sclerosis pathogenesis: an overview.

2014

The management of multiple sclerosis by reference centers in Italy: health demands and needs in Campania region.

2015

This cross-sectional study has investigated the diagnostic and therapeutic management of patients suffering from multiple sclerosis (MS) in the Campania Region (Italy). A survey involving all the reference centers for MS in Campania Region was conducted from March to August 2011. Centers responded to a web-administered questionnaire on management and clinical characteristics of MS patients. In the study period, 3263 patients (mean age 37 years, 66 % females) accessed the centers. Patients received a first diagnosis of MS in 161 cases (4.9 %). About 37 % of the subjects without a previous diagnosis came to the centers on their own initiative. All patients underwent a complete neurological ex…

Genetic burden in multiple sclerosis families

2013

A previous study using cumulative genetic risk estimations in multiple sclerosis (MS) successfully tracked the aggregation of susceptibility variants in multi-case and single-case families. It used a limited description of susceptibility loci available at the time (17 loci). Even though the full roster of MS risk genes remains unavailable, we estimated the genetic burden in MS families and assess its disease predictive power using up to 64 single-nucleotide polymorphism (SNP) markers according to the most recent literature. A total of 708 controls, 3251 MS patients and their relatives, as well as 117 twin pairs were genotyped. We validated the increased aggregation of genetic burden in mult…