Search results for "Clinical Laboratory Sciences"

showing 3 items of 13 documents

Differences between Human Plasma and Serum Metabolite Profiles

2011

BackgroundHuman plasma and serum are widely used matrices in clinical and biological studies. However, different collecting procedures and the coagulation cascade influence concentrations of both proteins and metabolites in these matrices. The effects on metabolite concentration profiles have not been fully characterized.Methodology/principal findingsWe analyzed the concentrations of 163 metabolites in plasma and serum samples collected simultaneously from 377 fasting individuals. To ensure data quality, 41 metabolites with low measurement stability were excluded from further analysis. In addition, plasma and corresponding serum samples from 83 individuals were re-measured in the same plate…

MaleSerumClinical Research DesignEpidemiologyScienceMetaboliteProtein metabolismType 2 diabetesPharmacologyBiologyBiochemistryPlasmachemistry.chemical_compoundDiagnostic MedicineBlood plasmaPathologymedicineMetabolomeHumansClinical EpidemiologyBiologyAgedAged 80 and overClinical ChemistryReproducibilityMultidisciplinaryChromatographyQChromatography; Metabolomics; Collection; Samples; Issues; AcidRReproducibility of ResultsMiddle Agedmedicine.diseaseClinical Laboratory SciencesBiomarker EpidemiologychemistrySmall MoleculesBlood ChemistryMetabolomeMedicineBiomarker (medicine)FemaleBiomarkersDrug metabolismResearch ArticleGeneral PathologyPLoS ONE
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White blood cell counts as risk markers of developing metabolic syndrome and its components in the Predimed study.

2013

Journal Article; Multicenter Study; Randomized Controlled Trial; Research Support, Non-U.S. Gov't; TRIAL REGISTRATION Controlled-Trials.comISRCTN35739639. BACKGROUND The Metabolic Syndrome (MetS) is a cluster of metabolic abnormalities that includes hyperglucemia, hypertension, dyslipidemia and central obesity, conferring an increased risk of cardiovascular disease. The white blood cell (WBC) count has been proposed as a marker for predicting cardiovascular risk. However, few prospective studies have evaluated the relationship between WBC subtypes and risk of MetS. METHODS Participants were recruited from seven PREDIMED study centers. Both a baseline cross-sectional (n = 4,377) and a prospe…

MaleSíndrome metabòlicaMediterranean dietNeutrophilsEpidemiologyEstudios transversalesMetabolic disorders:Named Groups::Persons::Age Groups::Adult::Aged::Aged 80 and over [Medical Subject Headings]Disease:Named Groups::Persons::Age Groups::Adult::Middle Aged [Medical Subject Headings]Diet Mediterranean:Analytical Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Statistics as Topic::Probability::Risk::Risk Factors [Medical Subject Headings]:Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans [Medical Subject Headings]Leukocyte CountLymphocitesRisk FactorsBlood plasmaPathologyMedicineProspective StudiesProspective cohort studyAged 80 and overMetabolic SyndromeClinical ChemistryMultidisciplinary:Analytical Diagnostic and Therapeutic Techniques and Equipment::Therapeutics::Nutrition Therapy::Diet Therapy::Diet Mediterranean [Medical Subject Headings]QRMiddle AgedMetabolic syndromeClinical Laboratory Sciences1932-6203:Analytical Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Epidemiologic Study Characteristics as Topic::Epidemiologic Studies::Cross-Sectional Studies [Medical Subject Headings]medicine.anatomical_structureCholesterolCardiovascular diseasesCardiovascular DiseasesMedicineWhite blood cellsFemalePublic HealthEnfermedades cardiovascularesResearch Articlemedicine.medical_specialty:Analytical Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Epidemiologic Study Characteristics as Topic::Epidemiologic Studies::Cohort Studies::Longitudinal Studies::Prospective Studies [Medical Subject Headings]Recuento de linfocitosScience:Check Tags::Male [Medical Subject Headings]Mediterranean cookingDiagnostic MedicineInternal medicineWhite blood cell:Analytical Diagnostic and Therapeutic Techniques and Equipment::Diagnosis::Diagnostic Techniques and Procedures::Clinical Laboratory Techniques::Cytological Techniques::Cell Count::Blood Cell Count::Leukocyte Count::Lymphocyte Count [Medical Subject Headings]Cuina mediterràniaHumansLymphocyte CountObesity:Named Groups::Persons::Age Groups::Adult::Aged [Medical Subject Headings]:Diseases::Cardiovascular Diseases [Medical Subject Headings]Cardiovascular Disease EpidemiologyAged:Diseases::Nutritional and Metabolic Diseases::Metabolic Diseases::Metabolic Syndrome X [Medical Subject Headings]business.industryMalalties cardiovascularsRecuento de leucocitosSíndrome X metabólicomedicine.diseaseObesityLong-Term CareDieta mediterránea:Analytical Diagnostic and Therapeutic Techniques and Equipment::Diagnosis::Diagnostic Techniques and Procedures::Clinical Laboratory Techniques::Cytological Techniques::Cell Count::Blood Cell Count::Leukocyte Count [Medical Subject Headings]Biomarker EpidemiologyCross-Sectional Studies:Check Tags::Female [Medical Subject Headings]GeriatricsImmunologyClinical ImmunologyPreventive MedicineMetabolic syndrome:Anatomy::Cells::Blood Cells::Leukocytes::Granulocytes::Neutrophils [Medical Subject Headings]businessDyslipidemiaBiomarkersGeneral Pathology
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Blood Component Therapy and Coagulopathy in Trauma: A Systematic Review of the Literature from the Trauma Update Group

2016

Background Traumatic coagulopathy is thought to increase mortality and its treatment to reduce preventable deaths. However, there is still uncertainty in this field, and available literature results may have been overestimated. Methods We searched the MEDLINE database using the PubMed platform. We formulated four queries investigating the prognostic weight of traumatic coagulopathy defined according to conventional laboratory testing, and the effectiveness in reducing mortality of three different treatments aimed at contrasting coagulopathy (high fresh frozen plasma/packed red blood cells ratios, fibrinogen, and tranexamic acid administration). Randomized controlled trials were selected alo…

Tranexamic acidPhysiologyGlycobiologylcsh:MedicineCardiovascular MedicinePathology and Laboratory MedicineBiochemistryVascular Medicinelaw.inventionDatabase and Informatics MethodsFresh frozen plasma0302 clinical medicineRandomized controlled trialCoagulopathyAnimal CellslawAntifibrinolytic agentFibrinogen; Fresh frozen plasma; Tranexamic acid; Antifibrinolytic agent.Medicine and Health Sciences030212 general & internal medicineDatabase Searchinglcsh:ScienceMultidisciplinaryPlasma ExchangeHematologyBlood Coagulation DisordersClinical Laboratory SciencesAntifibrinolytic AgentsBody FluidsBloodtraumaTranexamic AcidCardiovascular DiseasesResearch DesignMeta-analysisObservational StudiesFresh frozen plasmaAnatomyCellular TypesResearch ArticlePlateletsmedicine.medical_specialtyDeath RatesHemorrhageBlood Component TransfusionResearch and Analysis MethodsExternal validity03 medical and health sciencesSigns and SymptomsPopulation MetricsDiagnostic MedicinemedicineCoagulopathyHumansBlood TransfusionMortalityIntensive care medicineBlood CoagulationAntifibrinolytic Agents; Blood Coagulation Disorders; Humans; Mortality; Plasma Exchange; Tranexamic Acid; Wounds and Injuries; Blood Component Transfusion; Biochemistry Genetics and Molecular Biology (all); Agricultural and Biological Sciences (all)DemographyGlycoproteinsBlood CellsAntifibrinolytic agentPopulation BiologyCoagulation DisordersTransfusion Medicinebusiness.industrylcsh:RBleedingAntifibrinolytic agent.Biology and Life SciencesFibrinogen030208 emergency & critical care medicineCell Biologymedicine.diseaseSurgeryPeople and PlacesWounds and Injurieslcsh:QObservational studyPacked red blood cellsbusinessPLOS ONE
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