Search results for "Clusterin"
showing 10 items of 478 documents
Short term Dynamics of tourist Arrivals: What do destination have in common?
2012
This work aims to detect the common short term dynamics to yearly time series of 413 Italian tourist areas. We adopt the clustering technique of Abraham et al. (Scand J Stat. 30:581–595, 2003) who propose a two-stage method which fits the data by B-splines and partitions the estimated model coefficients using a k-means algorithm. The description of each cluster, which identifies a specific kind of dynamics, is made through simple descriptive cross tabulations in order to study how the location of the areas across the regions or their prevailing typology of tourism characterize each group.
Topographic maps for clustering and fast identification of bacteria using 16s housekeeping gene
2012
In microbial identification the standard method to attribute a specific name to a bacterial isolate relays on the comparison of morphologic and phenotypic characters to those described for type or typical strains. In the last years a new standard for identifying bacteria using genotypic information began to be developed. In this new approach phylogenetic relationships of bacteria could be determined by comparing a stable part of the bacteria genetic code, the so called "housekeeping genes". The most commonly used gene for taxonomic purposes for bacteria is the 16S rRNA. The goal of this chapter is to show that genotypic features can be used to build a topographic map for clustering of a lar…
CLUSTERING TOURIST LOCAL SYSTEMS BY VERTEX PARTITIONING AND LOCAL SEARCH
2014
Nonostante l’industria del turismo venga riconosciuta come un settore trainante per l’intera economia di un Paese, a tutt’oggi si registra una mancanza di criteri e metodologie ai fini della localizzazione, promozione e gestione di un Sistema Turistico Locale (STL). A tal fine, nel presente lavoro viene proposto un approccio di tipo quantitativo al problema sia della localizzazione che del dimensionamento ottimale di un STL tenendo conto di criteri e/o vincoli di natura geografica, economica e demografica. Il problema di ottimizzazione è rappresentato su grafo ed è risolto ricorrendo all’algoritmo di ricerca locale di Threshold Accepting (TA). Despite the importance of tourism as a leading …
Nerve growth factor and epidermal growth factor stimulate clusterin gene expression in PC12 cells
1999
Clusterin (apolipoprotein J) is an extracellular glycoprotein that might exert functions in development, cell death and lipid transport. Clusterin gene expression is elevated at sites of tissue remodelling, such as differentiation and apoptosis; however, the signals responsible for this regulation have not been identified. We use here the clusterin gene as a model system to examine expression in PC12 cells under the control of differentiation and proliferation signals produced by nerve growth factor (NGF) and by epidermal growth factor (EGF) respectively. NGF induced clusterin mRNA, which preceded neurite outgrowth typical of neuronal differentiation. EGF also activated the clusterin mRNA, …
Relation entre transitivité et structure de communauté dans les réseaux complexes
2011
The relation between community structure and other topological properties in complex networks, has not been analyzed clearly. In this preliminary study, we explore experimentally the potential link between transitivity and community structure. We study the evolution of transitivity based on the quality of the community structure on artificially generated networks. Then we observe the evolution of community structure according to transitivity value. The results show a relationship between high transitivity and community structure. Additional analytical work is needed to identify the exact nature of this relationship.
Wildfire Monitoring Based on Energy Efficient Clustering Approach for FANETS
2022
Forest fires are a significant threat to the ecological system’s stability. Several attempts have been made to detect forest fires using a variety of approaches, including optical fire sensors, and satellite-based technologies, all of which have been unsuccessful. In today’s world, research on flying ad hoc networks (FANETs) is a thriving field and can be used successfully. This paper describes a unique clustering approach that identifies the presence of a fire zone in a forest and transfers all sensed data to a base station as soon as feasible via wireless communication. The fire department takes the required steps to prevent the spread of the fire. It is proposed in this study…
Cilvēkresursu ietekme organizācijas inovācijas procesā.
2016
Mūsdienās viss ir vērsta uz inovāciju. Ja mēs skatāmies uzmanīgāk jauninājumiem, tā saistīta ar radīšanu kā evolūcija un procesu dzīvē, kas noved, kā arī citu sugu, pastāvēt. No ekonomiskā viedokļa patērētājs būs pirkt preci vai pakalpojumu, ja tās īpašības ir kaut kas atkal vai pievilcīgs, tikai, vai tas ir vai šķiet, ka jauns vismaz iegūt mūsu uzmanību. Visā pasaulē, uzņēmumiem un uzņēmējiem ir pilnībā izprata šo parādību un tas kopš tirdzniecisko apmaiņu sākumstadijā. Kopš tā laika uzņēmums piedzīvoja lielu attīstību tautsaimniecībā un zinātnē. Pēc piecpadsmit gadus pavadīja divdesmit pirmajā gadsimtā, inovāciju nekad nav bijis tik ātri, un, šķiet, lai apturētu. Tas ir iemesls, kāpēc ino…
Molecular docking and pharmacogenomics of vinca alkaloids and their monomeric precursors, vindoline and catharanthine.
2011
International audience; Vinblastine and vincristine are dimeric indole alkaloids derived from (formerly: ). Their monomeric precursor molecules are vindoline and catharanthine. While vinblastine and vincristine are well-known mitotic spindle poisons, not much is known about vindoline and catharanthine. Vindoline and catharanthine showed weak cytotoxicity, while vinblastine, vincristine, and the semisynthetic vindesine and vinorelbine revealed high cytotoxicity towards cancer cells. This may reflect a general biological principle of poisonous plants. Highly toxic compounds are not only active towards predators, but also towards plant tissues. Hence, plants need mechanisms to protect themselv…
Part-of-Speech Induction by Singular Value Decomposition and Hierarchical Clustering
2006
Part-of-speech induction involves the automatic discovery of word classes and the assignment of each word of a vocabulary to one or several of these classes. The approach proposed here is based on the analysis of word distributions in a large collection of German newspaper texts. Its main advantage over other attempts is that it combines the hierarchical clustering of context vectors with a previous step of dimensionality reduction that minimizes the effects of sampling errors.
Data Stream Clustering for Application-Layer DDoS Detection in Encrypted Traffic
2018
Application-layer distributed denial-of-service attacks have become a serious threat to modern high-speed computer networks and systems. Unlike network-layer attacks, application-layer attacks can be performed using legitimate requests from legitimately connected network machines that make these attacks undetectable by signature-based intrusion detection systems. Moreover, the attacks may utilize protocols that encrypt the data of network connections in the application layer, making it even harder to detect an attacker’s activity without decrypting users’ network traffic, and therefore violating their privacy. In this paper, we present a method that allows us to detect various application-l…