Search results for "CoDA"

Pyriproxyfen, a juvenoid hormone analog, does not induce male production in parthenogenetic lineages of Eucypris virens (Crustacea: Ostracoda)

2007

Analogs of juvenoid hormones are increasingly recommended for controlling insect pests in agriculture. One of these analogs, pyriproxyfen, was found to be very potent in inducing male production in Daphnia under laboratory conditions, even after acute exposure. Other studies also demonstrated a major role of juvenoid hormones for the sex determination in arthropods that have sex chromosomes. We exposed parthenogenetic lineages of the freshwater ostracod Eucypris virens to a wide range of pyriproxyfen concentrations, and compared mortality and fecundity between treated and control animals. Animals exposed to the highest concentrations of pyriproxyfen (3-30 nM) experienced a higher mortality …

The role of Aurora-A inhibitors in cancer therapy

2007

Recently, new chemotherapy agents which target the non-structural components of mitosis have been developed. An important protein involved in several mitotic phases is the Aurora-A protein. By means of the phosphorylation of different substrates, Aurora-A regulates the correct development of the various phases of mitosis. The kinase activity of this protein makes Aurora-A an excellent candidate as an oncogene. The first data of Aurora-A involvement in cancer regarded the identification of Aurora-A overexpression in primary breast and colon tumour samples. With regard to the predictive role of Aurora-A, it has been shown that its overexpression disrupts the spindle checkpoint activated by pa…

Transcodage des nombres chez l'enfant : approche développementale, inter-linguistique et différentielle

2010

Number transcoding in children is a domain rarely investigated. The PhD goal is to test the main predictions allowed by the transcoding model “ADAPT” of Barrouillet et al. (2004) in particular its ADAPTBASIC version concerning transcoding at the beginning of learning. Unlike the other transcoding models (e.g., McCloskey on 1992), ADAPT is a developmental, asemantic and procedural model. In this research the concerned transcoding allows to shift the verbal form of number to Arabic form. This thesis questions the acquisition of transcoding and its development with learning, as well as the impact of the inter-linguistic and individual differences. To reach these objectives, we adopted a develo…

Intracellular route of canine parvovirus entry.

1998

ABSTRACT The present study was designed to investigate the endocytic pathway involved in canine parvovirus (CPV) infection. Reduced temperature (18°C) or the microtubule-depolymerizing drug nocodazole was found to inhibit productive infection of canine A72 cells by CPV and caused CPV to be retained in cytoplasmic vesicles as indicated by immunofluorescence microscopy. Consistent with previously published results, these data indicate that CPV enters a host cell via an endocytic route and further suggest that microtubule-dependent delivery of CPV to late endosomes is required for productive infection. Cytoplasmic microinjection of CPV particles was used to circumvent the endocytosis and membr…

Three-dimensional kernel-based coda attenuation imaging of caldera structures controlling the 1982-84 Campi Flegrei unrest

2019

Abstract Coda-wave attenuation imaging has risen as a state-of-the-art technique to depict volcanic structures using their dispersion effects. The 1982–84 seismic and deformation unrest at Campi Flegrei caldera (Italy) is a unique example of non-eruptive volcanic activity in a structured caldera. Here, we propose the first application of 3D coda-attenuation kernels to image caldera structures at multiple frequencies during unrest. Using sensitivity kernels is necessary to assess the effective resolution of coda imaging in highly heterogeneous volcanoes. The technique relies on the solution of Paasschens' equations in the framework of radiative transfer theory. The results map coda attenuati…

The site of fertilisation determines dorsoventral polarity but not chirality in the zebra mussel embryo

1998

The dorsoventral polarity of unequally cleaving spiralian embryos becomes established at an early stage. The factors determining the position of the dorsoventral axis are still unknown. We present data showing that the sperm entry point (SEP) in both normal development and under experimental conditions determines the position of the first cleavage furrow in Dreissena embryos. The position of the spindles at second cleavage is directed by the site of fertilisation also, and the large, dorsal D quadrant of the 4-cell stage always forms opposite the SEP. The spiral chirality at third cleavage seems to be independent of both the fertilisation point and the arrangement of the quadrants. Dextral …

Understanding seismic path biases and magmatic activity at Mount St Helens volcano before its 2004 eruption

2020

SUMMARY In volcanoes, topography, shallow heterogeneity and even shallow morphology can substantially modify seismic coda signals. Coda waves are an essential tool to monitor eruption dynamics and model volcanic structures jointly and independently from velocity anomalies: it is thus fundamental to test their spatial sensitivity to seismic path effects. Here, we apply the Multiple Lapse Time Window Analysis (MLTWA) to measure the relative importance of scattering attenuation vs absorption at Mount St Helens volcano before its 2004 eruption. The results show the characteristic dominance of scattering attenuation in volcanoes at lower frequencies (3–6 Hz), while absorption is the primary atte…

Ostracods of Mediterranean temporary inland waters (Greece, Southern Italy, and Malta)

2015

Occlusion-derived baculovirus: interaction with human cells and evaluation of the envelope protein P74 as a surface display platform.

2008

To develop complementary baculovirus-based tools for gene delivery and display technologies, the interaction of occlusion-derived baculovirus (ODV) with human cells, and the functionality of the P74 ODV envelope protein for display of the IgG-binding Z domains (ZZP74) were evaluated. The cellular binding of ODV was concentration-dependent and saturable. Only minority of the bound virions were internalized at both 37 and 4 degrees C, suggesting usage of direct membrane fusion as the entry mode. The intracellular transport of ODV was confined in vesicular structures peripheral to the plasma membrane, impeding subsequent nuclear entry and transgene expression. Transduction of ODV was not rescu…

A Laboratory Dust Generator Applying Vibration to Soil Sample: Mineralogical Study and Compositional Analyses

2020

International audience; A laboratory study was carried out using a vibrating system (SyGAVib) to produce aerosols from four soils collected in the central Tunisian region around Sfax. The aim of this device is to mimic dust emission by natural wind erosion. Using compositional analysis, the dust produced was compared to (i) dust generated in a wind tunnel by the same soils, (ii) fine sieved and (iii) original bulk soils, and (iv) naturally occurring aerosol samples collected in the same area. The relative quartz content strongly decreases from bulk to fine soils, and again from fine soils to both wind tunnel and vibration‐generated aerosols. Compositional data analysis (CoDA) clearly shows …