Search results for "CoV"

showing 10 items of 9749 documents

Synthesis, antiproliferative activity, and in silico insights of new 3-benzoylamino-benzo[ b ]thiophene derivatives

2014

A new series of 3-benzoylamino-5-imidazol-5-yl-benzo[b]thiophenes and the parent amino derivatives were synthesized and screened as antitumor agents. All tested compounds showed concentration-dependent antiproliferative activity profile against HeLa cell line, exhibiting GI50 values in the low micromolar range. The most active compounds were tested in cell cycle perturbation experiments. A rapid accumulation of cells in the G2/M phase, with a concomitant reduction of cells in both the S and G0/G1 phases, was observed, suggesting that cell exposure to selected derivatives produces mitotic failure. To rationalize the biological results, the 3-benzoylamino-benzo[b]thiophenes were analyzed thro…

thiopheneVLAK protocolStereochemistryIn silicoCellAntineoplastic AgentsMechanism of actionHeLa CellHeLaAntineoplastic AgentStructure-Activity Relationship3-Benzoylamino-5-imidazol-4-yl-benzo[b]Settore BIO/10 - BiochimicaDrug DiscoverymedicineHumansMoietyComputer SimulationMitosisCell ProliferationPharmacologyAntitumor agentsbiologyDose-Response Relationship DrugMolecular StructureChemistryDrug Discovery3003 Pharmaceutical ScienceMedicine (all)Cell CycleOrganic ChemistryAntitumor agentG2/M phaseGeneral MedicineSettore CHIM/06 - Chimica OrganicaHeLa cell linebiology.organism_classificationSettore CHIM/08 - Chimica Farmaceuticamedicine.anatomical_structureCell cultureSettore CHIM/03 - Chimica Generale E InorganicathiophenesAntimitotic AgentTopoisomerase-II InhibitorDrug Screening Assays AntitumorHeLa CellsHuman
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The use of the Dark Web as a COVID-19 information source : A three-country study

2022

The Dark Web (i.e., the anonymous web or Darknet) contains potentially harmful COVID-19-related information and content such as conspiracy theories and forged certificates. The Dark Web may particularly attract individuals who are suspicious about the pandemic, but there is no research concerning the use of the Dark Web as a COVID-19 information source. In this study, we investigated the role of COVID-19 skepticism, online activities, and loneliness in the use of the Dark Web platforms as a COVID-19 information source. The data (N = 3000) were gathered in April 2021 from 18 to 75-year-old respondents from Finland (n = 1000), Sweden (n = 1000) and the United Kingdom (n = 1000). The responden…

tiedonlähteetanonymityonline informationSociology and Political Sciencesocial mediaCOVID-19sosiaalinen mediaHuman Factors and ErgonomicsDark webkansainvälinen vertailupandemiatEducationanonyymiverkotluottamusBusiness and International Managementmisinformationverkkoaineistoanonymiteettirokotevastaisuus
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"Missed" Information: A Moral Failing that Erodes Efforts to Tackle the COVID-19 Pandemic.

2021

tiedonvälitysSARS-CoV-2Public Health Archivemissed informationcoronavirusCOVID-19tiedonsaantiterveysosaaminenMoralspandemiathealth informationinfodemiainfodemiclukutaitoInfluenza HumanCommentaryHumansPublic aspects of medicineRA1-1270lukihäiriötPandemicsreading disabilitiesInternational journal of public health
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It’s Beyond Our Group ZPD : A Sociocultural Approach to the Unsuccessful Self-treatment of Writer’s Block in Times of COVID-19

2020

This study is a replication of Upper (1974). Our results are identical. We too have been unable to focus and accomplish our writing goals since the beginning of the global pandemic. We are certainly not alone, and we would like to recognize all of our colleagues who have also had to take on additional responsibilities at work and at home over the past year that have made writing nearly impossible. nonPeerReviewed

tieteellinen kirjoittaminenpoikkeusolotCOVID-19
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Associations of Work-Family Conflict with Family-Specific, Work-Specific, and Well-Being-Related Variables in a Sample of Polish and Ukrainian Adults…

2022

The conflict between work and family demands increased during the COVID-19 pandemic due to changes in lifestyle related to the lockdown. This study examines the associations between work-family conflict (WFC) and family-work conflict (FWC) with work-specific, family-specific, and well-being-related variables during the second wave of the COVID-19 pandemic. The results may be used in practice to improve the well-being of employees by adjusting home-based work and family areas of life to dynamic changes during the pandemic. The sample of 736 adults from Poland (53.26%) and Ukraine (46.74%), aged between 19 and 72 (M = 39.40; SD = 10.80), participated in the study. The cross-sectional study wa…

time pressureAdultwork-family conflictFamily ConflictHealth Toxicology and Mutagenesisperceived stressCOVID-19 pandemicYoung AdultSurveys and QuestionnairesgenderHumansChildPandemicsAgedparenthoodanxiety; COVID-19 pandemic; depression; gender; parenthood; perceived stress; time pressure; relationship status; remote work; work-family conflictPublic Health Environmental and Occupational HealthCOVID-19Middle Agedanxietyrelationship statusCross-Sectional Studiesdepressionremote workCommunicable Disease ControlFemalePolandStress PsychologicalInternational journal of environmental research and public health
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Toimitustöitä koronan aikaan

2020

toimitustyöCOVID-19
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Predictors of changing patterns of adherence to containment measures during the early stage of COVID-19 pandemic: an international longitudinal study

2023

Abstract Background Identifying common factors that affect public adherence to COVID-19 containment measures can directly inform the development of official public health communication strategies. The present international longitudinal study aimed to examine whether prosociality, together with other theoretically derived motivating factors (self-efficacy, perceived susceptibility and severity of COVID-19, perceived social support) predict the change in adherence to COVID-19 containment strategies. Method In wave 1 of data collection, adults from eight geographical regions completed online surveys beginning in April 2020, and wave 2 began in June and ended in September 2020. Hypothesized pre…

torjuntaminäpystyvyysDisease containment measuresHealth PolicyPublic Health Environmental and Occupational HealthCOVID-19sosiaalinen tukipitkittäistutkimussitoutuminenprososiaalisuuskansainvälinen vertailupandemiatVirusMedida de seguridadCoronavirusContención de riesgos biológicostoimenpiteetAdherencetartuntatauditterveyskäyttäytyminenProsocialityLongitudinal study
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Il Pnnr e le economie del turismo in Italia: le disparità regionali e le politiche

2022

The Italian regions show marked differences in the pattern of tourism development. These disparities can be offset by implementing a shared plan that supports the post-pandemic restart and strengthens its resilience to external shocks. The multiannual programming initiative launched by the EU with the National Recovery and Resilience Plan (PNRR) aims to address the consequences of the exogenous shocks triggered by the crisis from Covid-19 on the European production system. According to a top-down strategy articulated in a national plan and regional and sub-regional action plans, the large number of economic resources foreseen in the Plan will produce significant effects. The Pnrr's general …

tourism economics regional policies regional dispsrities covid-19 pandemic efgfects resilenceSettore SECS-P/06 - Economia Applicata
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Understanding prevention measures and tourist behavior in Croatia during the COVID-19 pandemic. A mixed-method approach

2022

This study investigates the adoption of prevention measures in Croatia during the COVID-19 pandemic and its relationship with tourist behavior. The research adopts a mixed-method approach as it examines both practitioners’ and tourists’ viewpoints. A qualitative study was conducted with eight destination service providers, while the quantitative study took place among 333 international tourists during their stay in the country. Results from the qualitative study show that the most frequently employed prevention measures are cleaning and disinfection of customer-use spaces, the use of hand sanitizers, mandatory face masks for employees and guests, and social distancing. Tourism service provi…

tourist destinationEconomics and Econometricsprevention measuresCOVID-19 pandemicUNESCO::CIENCIAS ECONÓMICASPrevention measures ; tourist behavior ; sociodemographics ; tourist destination ; mixed-method ; COVID-19 pandemictourist behaviorsociodemographicsmixed-methodEconomic Research-Ekonomska Istraživanja
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Environmental effects on the covariation among pace-of-life traits

2019

Pace‐of‐life syndromes (POLSs) are suites of life‐history, physiological and behavioural traits that arise due to trade‐offs between allocation to current and future reproduction. Traits generally show covariation that can arise from genetic and environmental influences on phenotypes and constrain the independent evolution of traits, resulting in fitness consequences and impacts on population dynamics. The notion that correlations among traits may vary among populations along environmental gradients suggests an important role for the environment in shaping and maintaining POLSs. However, no synthesis has been attempted of the myriad ways in which environmental factors should influence POLSs…

trait covariancemedia_common.quotation_subjectlife‐historyBiologybepress|Life Sciences|Ecology and Evolutionary BiologyDevelopmental psychologybehaviourbepress|Life SciencespersonalityplasticitypredictabilityPersonalityAnimal Science and ZoologyPredictabilityLife historybepress|Life Sciences|Ecology and Evolutionary Biology|Behavior and EthologyenvironmentEcology Evolution Behavior and SystematicsPace of lifebepress|Life Sciences|Ecology and Evolutionary Biology|Evolutionmedia_common
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