Search results for "Cod"
showing 10 items of 2985 documents
The Nucleosome Remodeling Factor ISWI Functionally Interacts with the Hsr-ω non-coding RNA
2009
Rescuing CFTR Protein Function: 1,3,4-oxadiazoles versus 1,2,4-oxadiazoles as readthrough inducing drugs
In Cystic fibrosis (CF) disease nonsense mutations in the CFTR gene cause the absence of the CFTR protein expression and a more severe form of the disease. About 10% of patient affected by CF show a nonsense mutation. A potential treatment of this alteration is to promote translational readthrough of premature termination codons (PTCs) by translational readthrough inducing drugs such as Ataluren (1). We reported a rationale for Ataluren promoted readthrough of PTCs by computational approach and GFP-reporter cell-based assay (2) and the observed enhancement of readthrough activity by some Ataluren derivatives (3, 4). In this context we aimed to compare the 1,2,4-oxadiazole core of Ataluren w…
Comprehensive analysis of interacting proteins and genome-wide location studies of the Sas3-dependent NuA3 histone acetyltransferase complex
2014
Highlights • We characterise Sas3p and Gcn5p active HAT complexes in WT and deleted TAP-strains. • We confirm that Pdp3p interacts with NuA3, histones and chromatin regulators. • Pdp3p MS-analysis reveals its phosphorylation, ubiquitination and methylation. • Sas3p can substitute Gcn5p in acetylation of histone H3K14 but not of H3K9. • Genome-wide profiling of Sas3p supports its involvement in transcriptional elongation.
Wykorzystanie stopu Ni-Co jako katalizatora katody w jednokomorowym mikrobiologicznym ogniwie paliwowym
2017
Technologią, która wykorzystuje ścieki jako surowiec, zapewniając jednocześnie ich oczyszczanie oraz produkcję prądu, jest technologia mikrobiologicznych ogniw paliwowych. Technologia ta postrzegana jest jako wspomaganie tradycyjnego oczyszczania ścieków. Jednym z podstawowych problemów związanych z mikrobiologicznymi ogniwami paliwowymi jest niewielka ilość produkowanej energii elektrycznej. Gęstość prądu zależy od szybkości zarówno reakcji anodowych, jak i katodowych. Celem pracy było wykazanie możliwości wykorzystania stopu Ni-Co jako katalizatora elektrody tlenowej w jednokomorowym mikrobiologicznym ogniwie paliwowym. Badania objęły pomiary szybkości rozkładu H2O2 na analizowanym katali…
Tutkimusdatan avoimuussuositukset puntarissa – Amsterdamissa
2014
Hypervisor-Based White Listing of Executables
2019
We describe an efficient system for ensuring code integrity of an operating system (OS), both its own code and application code. The proposed system can protect from an attacker who has full control over the OS kernel. An evaluation of the system's performance suggests the induced overhead is negligible. peerReviewed
Radiation Response of Ce-Codoped Germanosilicate and Phosphosilicate Optical Fibers
2016
We report an experimental investigation on the effects of Ce-codoping in determining the radiation response of germanosilicate and phosphosilicate Optical Fibers (OFs) in the UV-Visible domain and up to doses of $1~\hbox{MGy}({\rm SiO}_{2})$ . We show that the addition of Ce strongly impacts the Radiation Induced Attenuation (RIA) of both types of fibers. In the first case the radiation induced losses increase, whereas in the second one decrease. By combining the online RIA measurements with the Electron Paramagnetic Resonance (EPR) ones, we are able to infer the basic microscopic mechanisms taking place under irradiation, which involve the cerium codopant and some of the known Ge-related o…
FREE SPACE OPTICS LINKS AFFECTED BY OPTICAL TURBULENCE: CHANNEL MODELING, MEASUREMENTS AND CODING TECHNIQUES FOR ERROR MITIGATION
2014
FSO is an optical wireless line-of-sight communication system able to offer good broadband performance, electromagnetic interference immunity, high security, license-free operation, low power consumption, ease of relocation, and straightforward installation. It represents a modern technology, significantly functional when it is impossible, expensive or complex to use physical connections or radio links. Unfortunately, since the transmission medium in a terrestrial FSO link is the air, these communications are strongly dependent on various atmospheric phenomena (e.g., rain, snow, optical turbulence and, especially, fog) that can cause losses and fading. Therefore, in worst-case conditions, i…
Optimización del tratamiento de daptomicina mediante índices farmacocinéticos y farmacodinámicos
2023
La antibioterapia óptima implica la utilización del régimen de dosificación del antimicrobiano adecuado para conseguir los mejores resultados clínicos con los mínimos efectos adversos para el paciente y el mínimo impacto en el desarrollo de resistencias. Con el fin de conseguir estos resultados en los tratamientos con daptomicina en la práctica clínica, se ha desarrollado un modelo farmacocinético/farmacodinámico de daptomicina, cuyo objetivo es seleccionar las pautas de administración más adecuadas para cada paciente de acuerdo con la sensibilidad del microorganismo causal de la infección garantizando la consecución de los parámetros farmacocinético/farmacodinámico objetivo (área bajo la c…
Il perché di alcuni vuoti
2011
Il saggio propone un'analisi del Codice antimafia approvato nell'ultimo scorcio del periodo di attività del governo Berlusconi. Più che soffermarsi su quanto in esso contenuto il saggio mette in evidenza quanto, nella stesusa del Codice, è stato omesso o taciuto. L’immagine che emerge delle organizzazioni criminali non tiene conto delle profonde evoluzioni attraversate negli anni. E la centralità della formazione e della cultura, pilastri fondamentali per coadiuvare le azioni di contrasto, non sono in alcun modo riconosciute.