Search results for "Cog"
showing 10 items of 17676 documents
Zum spezifischen Versorgungsbeitrag psychosozialer Krebsberatungsstellen – Sichtweisen der Ratsuchenden und Zuweisenden
2021
Ziel Ziel der Studie ist es, den spezifischen Versorgungsbeitrag von Krebsberatungsstellen (KBS) sowohl aus Sicht der Ratsuchenden wie aus Sicht der Zuweisenden in den Blick zu nehmen. Methodik Qualitatives Design mittels leitfadengestutzter face-to-face-Interviews mit Krebspatient/innen/Angehorigen und telefonischer Einzelinterviews mit Zuweisenden. Ergebnisse Insgesamt wurden 43 Ratsuchende und 30 Zuweisende befragt. In Bezug auf die Beratungsinhalte werden die psychoonkologische Begleitung und Hilfe zur Selbsthilfe in Kombination mit einer sozialrechtlichen Aufklarung uber zusatzliche Unterstutzungsleistungen als zentrale Merkmale wahrgenommen. In der Gruppe der Zuweisenden scheint jedoc…
Olfaction, émotions et comportements
2015
International audience; Le nez a ses raisons que la raison ignore. Les émotions olfactives sont souvent inconscientes et vont pourtant diriger nombreux de nos comportements. Ce lien étroit entre émotion et olfaction est dû au fait que certaines régions cérébrales sont à la fois impliquées dans les processus olfactifs et émotionnels (cortex frontal et amygdale). Dans les pathologies neurodégénératives, dont la maladie d’Alzheimer (MA), ces structures vont être atteintes à des stades plus ou moins sévères de la maladie. Au-delà d’une aide au diagnostic précoce, nous avons montré que l’utilisation d’odorants pourrait aider au diagnostic différentiel entre certains troubles de l’humeur et la ma…
EL PAPEL DE LA AUTOESTIMA EN LA PREVENCIÓN DEL VIH DE JÓVENES ESPAÑOLES
2017
Abstract.THE ROLE OF SELF-ESTEEM IN HIV PREVENTION AMONG SPANISH YOUNG PEOPLE SELF-ESTEEM INFLUENCES ON SEXUAL DEVELOPMENT AND RELATIONSHIPS OF YOUNG PEOPLE.Aims to examine the effects of the self-esteem on HIV prevention, 467 young people from the Valencian Community (Mage = 20.62; SD = 2.14) completed the Rosenberg Self-esteem Scale and the Aids Prevention Questionnaire by Ballester et al. (2007). Results showed statistically significant positive correlation between self-esteem and self-efficacy in condom use (p = .000), perceived competence (p = .041) or number of sexual partners (p = .001). On the other hand, statistically significant negative correlation were found between solidarity t…
Pediatric Psychology
2021
The attention and the intervention of psychology in the field of pediatrics, especially regarding mothers and childcare, whether in a hospital or not, is extremely longstanding [...]
Building Robustness into Translational Research
2020
AbstractNonclinical studies form the basis for the decision whether to take a therapeutic candidate into the clinic. These studies need to exhibit translational robustness for both ethical and economic reasons. Key findings confirmed in multiple species have a greater chance to also occur in humans. Given the heterogeneity of patient populations, preclinical studies or at least programs comprising multiple studies need to reflect such heterogeneity, e.g., regarding strains, sex, age, and comorbidities of experimental animals. However, introducing such heterogeneity requires larger studies/programs to maintain statistical power in the face of greater variability. In addition to classic sourc…
Analysis of Activity States of Local Neuronal Microcircuits in Mouse Brain
2018
Time series of neuronal activity corresponding to different activity states in mouse brain are analyzed in the time domain and the time-frequency domain. The signals are associated with either a slow wave brain state or a persistent brain state. For both states, characteristic spectral features are identified and a simple detector is proposed that is able to identify the brain state with low latency and high accuracy. In practice, being able to monitor the brain state online and in real time is crucial for improved in vivoexperiments and, ultimately, for a causal understanding of brain dynamics.
Predicción del estado nutricional a través de la calidad de vida y el patrón del sueño en ancianos con deterioro cognitivo
2019
Resumen Objetivo: establecer y analizar una posible relación entre el estado nutricional, el patrón de sueño y la calidad de vida en una muestra de pacientes con disfunción cognitiva. Participantes y método: estudio observacional y descriptivo de un grupo de casos con una muestra constituida por 48 personas mayores (65 años o más) que aceptaron participar en el estudio y vivían en Valencia (España). EuroQol (EQ-5D), Cuestionario de Oviedo del sueño (COS), Mini Mental State de Folsteisn (MMSE) y Mini Nutritional Assessment (MNA) se utilizaron para evaluar el caso de cada individuo. La asociación de variables se evaluó mediante la correlación entre las tres variables. Finalmente, para verific…
Betulinic Acid Exerts Cytotoxic Activity Against Multidrug-Resistant Tumor Cells via Targeting Autocrine Motility Factor Receptor (AMFR).
2018
Betulinic acid (BetA) is a naturally occurring pentacyclic triterpene isolated from the outer bark of white-barked birch trees and many other medicinal plants. Here, we studied betulinic acid's cytotoxic activity against drug-resistant tumor cell lines. P-glycoprotein (MDR1/ABCB1) and BCRP (ABCG2) are known ATP-binding cassette (ABC) drug transporters that mediating MDR. ABCB5 is a close relative to ABCB1, which also mediates MDR. Constitutive activation of the EGF receptor is tightly linked to the development of chemotherapeutic resistance. BetA inhibited P-gp, BCRP, ABCB5 and mutation activated EGFR overexpressing cells with similar efficacy as their drug-sensitive parental counterparts. …
2,3-Dihydrobenzofuran privileged structures as new bioinspired lead compounds for the design of mPGES-1 inhibitors
2016
International audience; 2,3-Dihydrobenzofurans are proposed as privileged structures and used as chemical platform to design small compound libraries. By combining molecular docking calculations and experimental verification of biochemical interference, we selected some potential inhibitors of microsomal prostaglandin E2 synthase (mPGES)-1. Starting from low affinity natural product 1, by our combined approach we identified the compounds 19 and 20 with biological activity in the low micromolar range. Our data suggest that the 2,3-dihydrobenzofuran derivatives might be suitable bioinspired lead compounds for development of new generation mPGES-1 inhibitors with increased affinity.
Exposure to a Highly Caloric Palatable Diet During Pregestational and Gestational Periods Affects Hypothalamic and Hippocampal Endocannabinoid Levels…
2016
Journal Article; Exposure to unbalanced diets during pre-gestational and gestational periods may result in long-term alterations in metabolism and behavior. The contribution of the endocannabinoid system to these long-term adaptive responses is unknown. In the present study, we investigated the impact of female rat exposure to a hypercaloric-hypoproteic palatable diet during pre-gestational, gestational and lactational periods on the development of male offspring. In addition, the hypothalamic and hippocampal endocannabinoid contents at birth and the behavioral performance in adulthood were investigated. Exposure to a palatable diet resulted in low weight offspring who exhibited low hypotha…