Search results for "Coi"

Affidabilità del bright liver nella diagnosi di steatosi epatica in pazienti con infezione da virus dell'immunodeficienza acquisita (HIV), da virus d…

2009

Imation of land surface emissivity differences in the split-window channels of AVHRR

1994

Abstract A method for estimating the difference between the channel emissivities in NOAA-AVHRR Channels 4 and 5 is proposed and applied to a data set from the HAPEX-MOBILHY experiment. The method is based on the separation between the atmospheric and emissivity effects in the brightness temperature difference measured with AVHRR Channels 4 and 5. Atmospheric profiles coincident to the satellite overpass and a radiative transfer model are required to estimate the atmospheric correction for brightness temperatures. With this procedure, the emissivity difference Δe is obtained at the satellite spatial and spectral resolution, which has a great interest for correcting thermal images with the sp…

Two new species of Brusqeulia Razowski & Becker, 2000 from the Neotropics, with comments on the systematic position of the genus in relation to the A…

2018

Two new species of the neotropical genus Brusqeulia Razowski & Becker, 2000, are described and illustrated: B. yunkensis Pérez Santa-Rita & Baixeras, sp. n. from Bolivia and B. araguensis Pérez Sant-Rita & Baixeras, sp. n. from Venezuela. The systematic position and diagnostic characters of the genus are reviewed, resulting in the synonymy of Pinhaisania Razowski & Becker, 2000, with Brusqeulia, and the combination B. crispula (Razowski & Becker, 2000), comb. n. New characters of the female genitalia are discussed.

Differences in the efficacy and safety among inhaled corticosteroids (ICS)/long-acting beta2-agonists (LABA) combinations in the treatment of chronic…

2015

Inhaled corticosteroids (ICS) are frequently recommended for the treatment of asthma and COPD, often in combination with long-acting beta2-agonists (LABA), depending on the severity of the disease and/or on the specific phenotype. Several ICS/LABA combinations are currently available that differ in their pharmacokinetic characteristics and dose of both components. Thus, this review assesses differences in the efficacy and the safety profiles of the ICS components in the two more frequently used ICS/LABA combinations (budesonide/formoterol and fluticasone/salmeterol) for the management of COPD. Whereas the basic mechanism of action is similar for all ICS (binding with the intracellular gluco…

Biotransformation in vitro of the 22R and 22S epimers of budesonide by human liver, bronchus, colonic mucosa and skin.

2001

The pharmacological effects of glucocorticoids are greatly influenced by their pharmacokinetic properties. In the present report, the in vitro biotransformation of the 22R and 22S epimers of the topical steroid budesonide was studied in the S-9 fraction of human liver, bronchus, skin and colonic mucosa. The disappearance of unchanged epimers of budesonide was measured during 90 min of incubation by high performance liquid chromatography. The rate of disappearance was high in human liver while little biotransformation occurred in bronchial tissue and colonic mucosa, and none was detected in the skin. A marked decay of the initial concentration of unchanged budesonide epimers was noticed afte…

La reconstrucción de la iglesia de san Juan de Elche y otras empresas neobizantinas de Serrano Peral

2016

Se lleva a cabo el estudio de la reconstrucción de la iglesia San Juan Bautista de Elche por Serrano Peral, a partir del análisis de los documentos custodiados en el Archivo General de la Administración del Estado correspondientes a la Junta Nacional de Reconstrucción de Templos Parroquiales, en los que se ponen de manifiesto dos modos de entender la arquitectura por parte de un mismo autor: un primer proyecto, dentro de las características acciones reconstructivas de la posguerra, y un segundo, enmarcado en los cambios experimentados por la arquitectura española a partir de los años 50, ejemplificadores del quehacer polifacético del arquitecto ilicitano y en el que se destaca su peculiar e…

Reduced T-cell receptor CD3ζ-chain protein and sustained CD3ε expression at the site of mycobacterial infection

2001

Control of mycobacterial infection by the cellular immune system relies both on antigen-presenting cells and on T lymphocytes. The quality of an effective cellular immune response is dependent on functional signal transduction residing in the cytoplasmic tails of the T-cell receptor CD3 components. In order to investigate potential effects of mycobacteria on T-cell receptor signalling, we examined the protein expression of T-cell signal transduction molecules (CD3zeta, ZAP-70, p59fyn, p56lck). In Western blots of peripheral blood mononuclear cells of Mycobacterium tuberculosis infected patients, only the CD3zeta-chain showed a marked reduction in protein expression. To investigate the situa…

Antibodies to PECAM-1 and glucocorticoids reduce leukocyte adhesion in adjuvant arthritis of the rat knee synovium in vivo.

2002

Objective and design: To demonstrate the effect of monoclonal antibodies to the adhesion-molecule PECAM-1 (CD31) and of prednisolone on leukocyte adhesion in rat adjuvant arthritis.¶Material: Adjuvant arthritis was induced in male CD®-rats (five groups of n=6) 18 days prior to measurements.¶Treatment: Mouse-monoclonal antibody to rat CD-31 at 200 μg/kg or prednisolone at 24 mg/kg were administered i.v. 15 minutes prior to measurements.¶Methods: Venules within the intact rat-knee synovium were focused by confocal laser scanning microscopy. Numbers of rolling and adherent leukocytes were assessed in vivo.¶Results: Induction of arthritis significantly increased rolling and adherent leukocytes …

A Key Regulatory Role of the Transcription Factor NFATc2 in Bronchial Adenocarcinoma via CD8+ T Lymphocytes

2009

AbstractThe Ca2+-regulated calcineurin/nuclear factor of activated T cells (NFAT) cascade controls alternative pathways of T-cell activation and peripheral tolerance. Here, we describe reduction of NFATc2 mRNA expression in the lungs of patients with bronchial adenocarcinoma. In a murine model of bronchoalveolar adenocarcinoma, mice lacking NFATc2 developed more and larger solid tumors than wild-type littermates. The extent of central tumor necrosis was decreased in the tumors in NFATc2(−/−) mice, and this finding was associated with reduced tumor necrosis factor-α and interleukin-2 (IL-2) production by CD8+ T cells. Adoptive transfer of CD8+ T cells of NFATc2(−/−) mice induced transforming…

Assessment of local cellular immunity in lung cancer by bronchoalveolar lavage.

1990

Small cell lung cancer (SCLC) is the most malignant of the pulmonary neoplasms and is associated with a poor local cellular immune response. 16 patients with non small cell lung cancer (NSCLC) and 11 patients with SCLC underwent bronchoalveolar lavage (BAL) in the lung which harbored the tumor in order to investigate the lymphocyte surface antigens utilizing the immunoperoxidase technique. Analysis of blood lymphocytes was performed in parallel. 8 patients with previous sarcoidosis in complete remission who underwent BAL and 10 normal blood donors served as controls. Among blood lymphocytes the CD3+, CD4+ and CD16+ cell populations were elevated significantly and the T4/T8 ratio was elevate…