Search results for "Colon"
showing 10 items of 2038 documents
Tecnologías de secuenciación masiva y PCR digital en la detección de ADN tumoral procedente de tejido y plasma en pacientes de colon localizado
2022
El cáncer de colon se sitúa como uno de los tumores más relevantes a nivel social, con una tasa de entre el 30 y 50% de recaídas tras la resección. Como herramienta de estudio en este tumor, la biopsia líquida se ha abierto paso en diferentes ámbitos, tales como la detección de la heterogeneidad tumoral o la enfermedad mínima residual (EMR). El fundamento de esta estrategia es detectar el ADN tumoral circulante (ctDNA), que se encuentra diluido en el ADN libre circulante (cfDNA), siendo necesario el uso de tecnologías aptas para la detección a frecuencias bajo el 1%. La hipótesis de esta tesis se apoya en variantes somáticas para detectar el ctDNA y definir la heterogeneidad tumoral, la EMR…
EFFICACY OF ZOLEDRONIC ACID IN PATIENTS WITH COLORECTAL CANCER METASTATIC TO BONE
2010
Introduction. Bone metastases are an emerging clinical problem in colorectal cancer patients probably related to survival increase. There are no data in literature about the role of BPs in the treatment of bone disease from colorectal cancer. We present the final data of a large Italian multicenter retrospective analysis. Methods. 264 colorectal cancer patients with occurrence of bone metastases have been included in the study. All patients were dead due to cancer at the moment of the study inclusion. Patients characteristics, Skeletal Related Events (SRE) data and median survival after bone metastases appearance have been collected in a master data base and statistically analyzed. The prim…
On the origin and diversification of Podolian cattle breeds: testing scenarios of European colonization using genome-wide SNP data
2021
AbstractBackgroundDuring the Neolithic expansion, cattle accompanied humans and spread from their domestication centres to colonize the ancient world. In addition, European cattle occasionally intermingled with both indicine cattle and local aurochs resulting in an exclusive pattern of genetic diversity. Among the most ancient European cattle are breeds that belong to the so-called Podolian trunk, the history of which is still not well established. Here, we used genome-wide single nucleotide polymorphism (SNP) data on 806 individuals belonging to 36 breeds to reconstruct the origin and diversification of Podolian cattle and to provide a reliable scenario of the European colonization, throug…
Damage identification by Lévy ant colony optimization
2010
This paper deals with the identification of incipient damage in structural elements by non-destructive test based on experimentally measured structural dynamical response. By applycation of the Hilbert transform to the recorded signal the so-called phase of the analytical signal is recovered and a proper functional is constructed in such a way that its global minimum gives a measure of the damage level, meant as stiffness reduction. Minimization is achieved by applying a modified Ant Colony Optimization (ACO) for continuous variables, inspired by the ants’ forageing behavior. The modification consists in the application of a new perturbation operator, based on alpha stable Lévy distribution…
Mechanisms of Autocrine and Paracrine Growth Control in Acute Myelogenous Leukemia
1990
Blast cells of a high proportion of patients with acute myelogenous leukemia (AML) proliferate in response to exogenous hematopoetic growth factors, both in vitro [9, 14, 26, 36, 48, 65] and in vivo [20]. Whereas leukemic colony-forming cells (L-CFCs) from most patients share their growth factor dependence with normal committed myeloid progenitor cells (CFU-GMs), some AML samples autonomously form colonies in agar and are therefore believed to bypass growth factor requirements [17, 42, 72]. Autocrine growth factor production has been identified as one mechanism used by AML blasts to supply various growth-promoting molecules. Moreover nontransformed accessory bone marrow cells have been show…
Histologie in vivo avec endomicroscopie confocale dans le diagnostic des cancers colorectaux
2005
L’endomicroscopie confocale constitue un nouvel outil diagnostique destine au diagnostic in vivo des modifications epitheliales constatees en cours de coloscopie. Apres l’application d’agents fluorescents, la technique permet d’obtenir en temps reel, une imagerie de la surface muqueuse et de la couche sous-muqueuse sous microscopie a haute resolution.
Hematopoietic Stem Cell Mobilization for Gene Therapy: The Combination of G-CSF+Plerixafor in Patients with Beta-Thalassemia Major Provides High Yiel…
2015
Abstract Hematopoietic stem cell engineering is a promising therapy to cure b-thalassemia, in particular for patients who lack a suitable BM donor for allogeneic transplantation. Since the engrafted gene-corrected stem cells will not have any selective advantage over the unmodified ones, the effectiveness of the therapy in this setting largely depends on the infusion of high numbers of gene-modified cells and on the conditioning regimen. The quality of the infused cells is also crucial for the clinical outcome and the duration of the therapeutic effect. HSPCs mobilization, particularly when G-CSF and plerixafor are used in combination, has been proved to be the optimal approach to harvest a…
B cells assume the command
2015
A proinflammatory B cell cytokine activates autoimmunity, and B cell depletion treats multiple sclerosis (Li et al., this issue).
Combining conventional chemotherapy and γδ T cell-based immunotherapy to target cancer-initiating cells.
2013
According to common beliefs, conventional anticancer chemotherapy is deleterious for the immune system. We have recently provided in vitro evidence indicating that conventional chemotherapy may potentiate, rather than impair, the long-term efficacy of γδ T cell-based anticancer immunotherapy.
A perspective analysis: microRNAs, glucose metabolism, and drug resistance in colon cancer stem cells
2021
Metabolism sustains the stemness of Cancer Stem Cells (CSCs), affecting, in turn, tumor heterogeneity, metastatic potential, and therapy resistance. Therefore, it is appealing to target CSCs metabolism as a new therapeutic approach. Consequently, we paid considerable attention to the anti-apoptotic microRNA miR-483-3p, that we reported being regulated by glucose metabolism in liver cancer cells. We investigated the therapeutic potential of targeting miR-483-3p by using the anti-glucose metabolism 2-deoxyglucose (2-DG) molecule in tumor Xenograft mouse model originating from two different Colon-Cancer Stem Cell lines (CCSC lines). We show that 2-DG treatment does not affect CCSCs during tumo…