Search results for "Colon"
showing 10 items of 2038 documents
Glimmering utopias: 50 years of African film
2010
The history of African film began in the 1960s with the independence of the colonies. Despite all kinds of political and economic difficulties, numerous films have been made since then, featuring wide-ranging processes of consolidation, differentiation and transformation which were characteristic of post-colonial sub-Saharan Africa. However, these feature films should not merely be viewed as back references to specifically African problems. The glimmering fictions are imagination spaces. They preserve ideas about how the post-colonial circumstances should be approached. Seen from this perspective, the history of African film may be studied as a history of African utopias. Die Geschichte des…
Reimagining cultural memory of the arctic in the graphic narratives of Oqaluttuaq
2021
The Greenlandic oral story-telling tradition, Oqaluttuaq, meaning “history,” “legend,” and “narrative,” is recognized as an important entry point into Arctic collective memory. The graphic artist Nuka K. Godtfredsen and his literary and scientific collaborators have used the term as the title of graphic narratives published from 2009 to 2018, and focused on four moments or ‘snippets’ from Greenland’s history (from the periods of Saqqaq, late Dorset, Norse settlement, and European colonization). Adopting a fragmentary and episodic approach to historical narrativization, the texts frame the modern European presence in Greenland as one of multiple migrations to and settlements in the Artic, ra…
Decolonising European minds through Heritage
2019
By analysing three museums exhibition, this article investigates how the history of European colonialism is approached in an attempt to identify potential for decolonising European minds. The case studies consist of a temporary exhibition (2016–2017) concerning German colonialism at the Deutsches Historisches Museum in Berlin; the permanent exhibition of the House of European History in Brussels and the permanent exhibition of the Sagres Promontory (Portugal), a heritage site related to the conquest of the Americas. The analysis will focus on three aspects: 1) acknowledgement of connections between colonial histories and their contemporary influences in and for Europe; 2) the role of histor…
Génesis y resolución de conflictos relacionados con la instalación de mezquitas y oratorios: el caso del oratorio de Singuerlín (Santa Coloma de Gram…
2017
Durante los últimos años, se han sucedido, en diferentes territorios del Estado español, los conflictos relacionados con la instalación de mezquitas y oratorios destinados a la práctica del culto musulmán. Este artículo analiza uno de los conflictos más intensos, el desatado en 2004 ante el intento de apertura del oratorio del barrio de Singuerlín en Santa Coloma de Gramenet. Se estudia su raíz, su evolución y el papel que jugó la mediación intercultural en su gestión. A partir de las entrevistas en profundidad efectuadas con los actores implicados, varios años después, se analizan los elementos estructurales del conflicto y se plantea una reflexión acerca de la forma en la que se ha ido co…
Molecular Identification of Yeasts Associated with Traditional Egyptian Dairy Products
2009
This study aimed to examine the diversity and ecology of yeasts associated with traditional Egyptian dairy products employing molecular techniques in yeast identification. A total of 120 samples of fresh and stored Domiati cheese, kariesh cheese, and "Matared" cream were collected from local markets and examined. Forty yeast isolates were cultured from these samples and identified using the restriction-fragment length polymorphism (RFLPs) of 5.8S-ITS rDNA region and sequencing of the domains D1 and D2 of the 26S rRNA gene. Yeasts were identified as Issatchenkia orientalis (13 isolates), Candida albicans (4 isolates), Clavispora lusitaniae (Candida lusitaniae) (9 isolates), Kodamaea ohmeri (…
Antitumoral activity of curcumin: an adjuvant therapeutic strategy
2021
Curcumin, an active substance contained in an Indian spice called turmeric or curcuma, is well known for its anti-inflammatory and antioxidant properties. In recent times, it was taken into account and studied as an antitumoral molecule, by relying on its interference on several biological mechanisms, such as the inhibition of inflammatory mediators, the enhancement of detoxifying enzymes’ action and processes of cell growth and proliferation. Studies show how the high dosage of curcumin in vitro inhibits colorectal tumor cells, pancreatic tumor cells, lung cancer cells and glioblastoma’s cells, interfering in signaling pathways as Wnt/β-catenin, NF-kB and PI3K/Akt and leading to cell cycle…
Activated kRas protects colon cancer cells from cucurbitacin-induced apoptosis: The role of p53 and p21
2008
Cucurbitacins have been shown to inhibit proliferation in a variety of cancer cell lines. The aim of this study was to determine their biological activity in colon cancer cell lines that do not harbor activated STAT3, the key target of cucurbitacin. In order to establish the role of activated kRas in the responsiveness of cells to cucurbitacins, we performed experiments in isogenic colon cancer cell lines, HCT116 and Hke-3, which differ only by the presence of an activated kRas allele. We compared the activity of 23, 24-dihydrocucurbitacin B (DHCB) and cucurbitacin R (CCR), two cucurbitacins that we recently isolated, with cucurbitacin I (CCI), a cucurbitacin with established antitumorigeni…
The role of reactive oxygen species and subsequent DNA-damage response in the emergence of resistance towards resveratrol in colon cancer models
2014
AbstractIn spite of the novel strategies to treat colon cancer, mortality rates associated with this disease remain consistently high. Tumour recurrence has been linked to the induction of resistance towards chemotherapy that involves cellular events that enable cancer cells to escape cell death. Treatment of colon cancer mainly implicates direct or indirect DNA-damaging agents and increased repair or tolerances towards subsequent lesions contribute to generate resistant populations. Resveratrol (RSV), a potent chemosensitising polyphenol, might share common properties with chemotherapeutic drugs through its indirect DNA-damaging effects reported in vitro. In this study, we investigated how…
The efficient bovine insulin presentation capacity of bone marrow-derived macrophages activated by granulocyte-macrophage colony-stimulating factor c…
1993
Bone marrow-derived macrophages (BMM phi) were shown before to function as antigen-presenting cells. We show here, that the antigen presentation capacity of BMM phi depends on the nature of the antigen and is differently regulated by the lymphokines interferon-gamma (IFN-gamma) and granulocyte/macrophage-colony-stimulating factor (GM-CSF). When bovine insulin (BI) was employed as antigen, only BMM phi treated with GM-CSF (GM-CSF-M phi) were efficient presenters, but when presentation of the antigens ovalbumin and conalbumin was tested, IFN-gamma-pulsed BMM phi (IFN-gamma-M phi) proved superior to GM-CSF-M phi. The lack of efficient BI presentation function of IFN-gamma-M phi was only obviou…
Chemotherapy Sensitizes Colon Cancer Initiating Cells to Vγ9Vδ2 T Cell-Mediated Cytotoxicity
2013
Colon cancer comprises a small population of cancer initiating stem cells (CIC) that is responsible for tumor maintenance and resistance to anti-cancer therapies, possibly allowing for tumor recapitulation once treatment stops. Combinations of immune-based therapies with chemotherapy and other anti-tumor agents may be of significant clinical benefit in the treatment of colon cancer. However, cellular immune-based therapies have not been experimented yet in the population of colon CICs. Here, we demonstrate that treatment with low concentrations of commonly used chemotherapeutic agents, 5- fluorouracyl and doxorubicin, sensitize colon CICs to Vc9Vd2 T cell cytotoxicity. Vc9Vd2 T cell cytotox…