Search results for "Colore"
showing 10 items of 1250 documents
Context matters-consensus molecular subtypes of colorectal cancer as biomarkers for clinical trials
2019
Abstract The Colorectal Cancer Subtyping Consortium identified four gene expression consensus molecular subtypes, CMS1 (immune), CMS2 (canonical), CMS3 (metabolic), and CMS4 (mesenchymal), using multiple microarray or RNA-sequencing datasets of primary tumor samples mainly from early stage colon cancer patients. Consequently, rectal tumors and stage IV tumors (possibly reflective of more aggressive disease) were underrepresented, and no chemo- and/or radiotherapy pretreated samples or metastatic lesions were included. In view of their possible effect on gene expression and consequently subtype classification, sample source and treatments received by the patients before collection must be ca…
Introduzione
2017
Nella cornice del Piano Colore Isole Egadi, il convegno internazionale “Identity | The Colors of Project” evidenzia il ruolo strategico dell’identità – di un’istituzione, di un’azienda, di un territorio – con particolare riferimento alle connotazioni identificative del colore. Qui, studiosi con competenze disciplinari diverse si confrontano sul tema spaziando in ambiti molto diversi: dal prodotto al cibo, dal web al car design, dalla fotografia alla brand identity.
Endoscopic confocal imaging.
2005
In vivo fluorescence endomicroscopy is a newly developed diagnostic tool enabling virtual in vivo histology of the mucosal layer during ongoing endoscopy. This review summarizes currently available data about the technique and clinical use of confocal endomicroscopy. Indications discussed include colorectal cancer evaluation, ulcerative colitis and surveillance, Barrett's esophagus, and detection of Helicobacter pylori infection in vivo.
What new endoscopic imaging modalities will become important in the diagnosis of IBD?
2008
Evaluation and management of hemorrhoids: Italian society of colorectal surgery (SICCR) consensus statement
2015
Hemorrhoids are one of the most common medical and surgical diseases and the main reason for a visit to a coloproctologist. This consensus statement was drawn up by the Italian society of colorectal surgery in order to provide practice parameters for an accurate assessment of the disease and consequent appropriate treatment. The authors made a careful search in the main databases (MEDLINE, PubMed, Embase and Cochrane), and all results were classified on the basis of the grade of recommendation (A-C) of the American College of Chest Physicians.
Natural polyphenols in cancer therapy.
2011
Natural polyphenols are secondary metabolites of plants involved in defense against different types of stress. Extracts containing these compounds have been used for thousands of years in traditional eastern medicine. Polyphenols act on multiple targets in pathways and mechanisms related to carcinogenesis, tumor cell proliferation and death, inflammation, metastatic spread, angiogenesis, or drug and radiation resistance. Nevertheless, reported effects claimed for polyphenols are controversial, since correlations between in vitro effects and in vivo evidence are poorly established. The main discrepancy between health claims versus clinical observations is the frequent use of nonphysiological…
Pharmacogenomics in colorectal carcinomas: Future perspectives in personalized therapy
2005
The recent introduction of new drugs such as capecitabine, irinotecan, and oxaliplatinum has greatly improved the clinical outcome of patients with advanced/metastatic colorectal cancer. Nevertheless, some patients may suffer from the adverse drug reactions which will probably be the main cause of chemotherapy failure. The goal of pharmacogenomics is to find correlations between therapeutic responses to drugs and the genetic profiles of patients; the different responses to a particular drug are due, in fact, not only to the specific clinico-pathological features of the patient or to environmental factors, but also to the ethnic origins and the particular individual's genetic profile. Genes …
Colorectal cancer: pharmacogenetics support for the correct drug prescription
2019
Pharmacogenetics (PGx) in clinical practice is a tool that the clinician can use to guide, in a personalized way, the most suitable treatment that will be administered to the patient. The objective of this review is to summarize in a practical and accessible rational way, the advances that currently exist for the application of PGx in colorectal cancer chemotherapy management through the study of the patients’ germline polymorphisms. To define the polymorphisms that can be applied, we rely on three fundamental cornerstones: the recommendations of drug regulatory agencies; the implementation guidelines prepared by expert consortia in PGx and information from clinical annotations (the drug/p…
LA VALUTAZIONE DELLA DURABILITÀ DI INTONACI FOTOCATALITICI
2014
Energy saving and the rational use of natural resources in the building process, nowadays, are very debated environmental issues, involving researchers and companies in the production and testing of innovative materials. Reducing the consumption of resources means more durable buildings, thus an important contribution in this way is given by the knowledge of the durability of products and building components. This is fundamental when innovative products are applied and no information are available on their service life. The research concerns the evaluation of the durability of cement-based photocatalytic coatings, containing different types of pigments, used for external finishing of buildi…
Valutazione sperimentale della durabilità di intonaci finalizzata alla manutenzione programmata
2010
La Legge 109/94 ha imposto per i nuovi interventi pubblici, la programmazione della manutenzione da redigersi in fase di progettazione esecutiva. La fase di gestione del bene edilizio assume, infatti, un’importanza strategica, nell’ottica di una ragionevole durata di vita utile espletata in un equilibrato rapporto qualità-costo globale, per la sostenibilità dell’intervento. Un contributo in tal senso è costituito dal contenimento nel consumo di risorse e di materie prime conseguibile attraverso il miglioramento del requisito di durabilità dell’edificio e delle sue parti, cosa possibile se si conosce il comportamento nel tempo di componenti e sistemi edilizi contestualizzati. Ciò vale anche …