Search results for "Comment"

Hybrid minimally invasive esophagectomy for esophageal cancer : less is more

2019

In a recently published multi-center randomized controlled trial ( New England Journal of Medicine 2019;380:152-162) Christophe Mariette and colleagues compared open transthoracic esophagectomy to hybrid esophagectomy (open thoracic phase, laparoscopic abdominal phase) for patients with resectable cancer of the middle or lower third of the esophagus (MIRO trial) (1).

Weight cycling in combat sports: revisiting 25 years of scientific evidence

2021

Abstract Background As combat sports are classified by body mass, many athletes engage in rapid weight loss (RWL) prior to competition so they can gain an advantage over lighter opponents. Following the weigh-in, athletes engage in rapid weight gain (RWG), whereby some athletes have been able to compete up to three weight categories greater than the official division weighed in at. Results Although the impact of weight cycling on performance remains equivocal, robust scientific evidence indicates serious acute and chronic negative consequences on physiological and health-related parameters. Still, weight cycling remains highly prevalent in combat sports, and interventions to limit or stop t…

Amazing IL-9: revealing a new function for an “old” cytokine

2012

Th9 cells are a subset of CD4+ Th cells that produce the pleiotropic cytokine IL-9. IL-9/Th9 can function as both positive and negative regulators of immune response, but the role of IL-9/Th9 in tumor immunity is unknown. We examined the role of IL-9/Th9 in a model of pulmonary melanoma in mice. Lack of IL-9 enhanced tumor growth, while tumor-specific Th9 cell treatment promoted stronger antitumor responses in both prophylactic and therapeutic models. Th9 cells also elicited strong host antitumor CD8+ CTL responses by promoting Ccl20/Ccr6-dependent recruitment of DCs to the tumor tissues. Subsequent tumor antigen delivery to the draining LN resulted in CD8+ T cell priming. In agreement with…

Misguided Effort with Elusive Implications

2016

Good self-control has been linked to adaptive outcomes such as better health, cohesive personal relationships, success in the workplace and at school, and less susceptibility to crime and addictions. In contrast, self-control failure is linked to maladaptive outcomes. Understanding the mechanisms by which self-control predicts behavior may assist in promoting better regulation and outcomes. A popular approach to understanding self-control is the strength or resource depletion model. Self-control is conceptualized as a limited resource that becomes depleted after a period of exertion resulting in self-control failure. The model has typically been tested using a sequential-task experimental p…

Future Research in Graves' Orbitopathy: From Priority Setting to Trial Design Through Patient and Public Involvement

2015

Graves' orbitopathy (GO) is a disfiguring autoimmune condition, which can sometimes cause blindness (1). The disease has profound effects on quality of life (2), psychological health (3), and socioeconomic status (4). Progress in understanding and treating this disease has been slow. However, recent advances include delineation of plausible immunological mechanisms (5), development of an animal model (6), and publication of randomized studies defining the role and limitations of intravenous steroids (7), rituximab (8,9), and selenium (10). Yet, some of this knowledge remains to be translated into improvement in clinical care. Access of patients to specialist treatments is patchy and seems t…

Review of: S. Seelentag, Der Pseudovergilische Culex, Stuttgart 2012

2013

Guidelines and Current Assessment of Health Care Responsibility in Italy

2020

Stefania Zerbo, Ginevra Malta, Antonina Argo Department of Health Promotion, Maternal and Child Care, “G. D’Alessandro”, Legal Medicine Section, University of Palermo, Palermo, ItalyCorrespondence: Stefania ZerboDepartment of Health Promotion, Maternal and Child Care, “G. D’Alessandro”, Legal Medicine Section, University of Palermo, via del Vespro N. 129, Palermo 90127, ItalyTel +39 33 3725 0209Fax +39 09 1655 3203Email stefania.zerbo@unipa.itAbstract: Clinical guidelines are a potential tool for improving the effectiveness and quality of healthcare, decreasing variability in clinical practice, and preventing adverse events. In the…

(Table 1) Age determination of sediment profile SO90-41KL/63KA

2002

The 14C ages of planktonic foraminifers Globigerinoides sacculifer bracketing the Younger Dryas in a d18O record of Globigerinoides ruber from a laminated sediment core on the Pakistani continental margin suggest that surface reservoir ages in the Arabian Sea were in excess of 1000 years during the deglaciation. A least squares error fit of a detailed 14C chronology to the (atmospheric) tree ring record gave variable early Holocene reservoir ages between 780 and 1120 years, well above the prebomb value of 640 years. Mid-Holocene reservoir ages are less well constrained but were probably closer to the prebomb value. The method used to fit individual core sections to the tree ring record was …

Oxygen isotope and salinity measurements of coastal surface waters in the Gulf of Maine

2020

These data include salinity and oxygen isotope measurements of water samples collected from coastal sites along the Gulf of Maine between 2003 and 2015. In particular, a suite of samples were collected along the coast of Maine, east of Penobscot Bay, on a monthly basis between April 2014 and March 2015. These data also include several freshwater samples collected from the Kennebec and Penobscot Rivers on a semi-monthly basis in 2014 and 2015. For the water samples with sample IDs starting with DSW, JSW, NSW, or OSW: The water samples were collected by hand from shore or boat using French square glass bottles with phenolic polycone lined caps. Salinity was measured using a Oakton SALT 6+ han…

(Table 2) Age determination of sediment core NIOP-C2_929

2007

In this study we present a sea surface temperature (SST) record from the western Arabian Sea for the last 20,000 years. We produced centennial-scale d18O and Mg/Ca SST time series of core NIOP929 with focus on the glacial-interglacial transition. The western Arabian Sea is influenced by the seasonal NE and SW monsoon wind systems. Lowest SSTs occur during the SW monsoon season because of upwelling of cold water, and highest SSTs can be found in the low-productivity intermonsoon season. The Mg/Ca-based temperature record reflects the integrated SST of the SW and NE monsoon seasons. The results show a glacial-interglacial SST difference of ~2°C, which is corroborated by findings from other Ar…