Search results for "Commentaries"
showing 10 items of 28 documents
Anti-inflammatory lipoxin A4 is an endogenous allosteric enhancer of CB1 cannabinoid receptor.
2012
Allosteric modulation of G-protein–coupled receptors represents a key goal of current pharmacology. In particular, endogenous allosteric modulators might represent important targets of interventions aimed at maximizing therapeutic efficacy and reducing side effects of drugs. Here we show that the anti-inflammatory lipid lipoxin A 4 is an endogenous allosteric enhancer of the CB 1 cannabinoid receptor. Lipoxin A 4 was detected in brain tissues, did not compete for the orthosteric binding site of the CB 1 receptor (vs. 3 H-SR141716A), and did not alter endocannabinoid metabolism (as opposed to URB597 and MAFP), but it enhanced affinity of anandamide at the CB1 receptor, thereby potentiating …
Physical inactivity and cardiovascular disease at the time of coronavirus disease 2019 (COVID-19).
2020
Commenting on Historical Writings in Medieval Latin Europe : A Reconnaissance
2015
Modern scholarship seems to undervalue medieval commentaries on historical writings. This article intends to bring this phenomenon to scholars’ attention by providing a preliminary overview of the forms and subjects of such commentaries. It examines various types of evidence including not only a few commentaries proper (Nicolas Trevet’s on Livy and John of Dąbrówka’s on Vincent of Cracow), but also different apparatus consisting of more or less systematic interlinear and marginal glosses and commentary-like additions to vernacular translations, mostly of Italian and French origin. It begins by considering various consultation-related signs and annotations, such as cross-references. Then, it…
Searching for Syntax in the Early Medieval Commentaries on Donatus
2023
This study aims at contributing to the reconstruction of the metalanguage and the specific terminology used by grammarians with reference to the reflection on syntax, as it emerges from the analysis of Late Antiquity and Early Middle Ages grammar texts. The study focuses on the description of prepositions within the commentaries on Donatus’s Artes. Despite the overall lack of a systematic treatment of syntax within the Greek-Latin grammatical tradition, the description of specific partes orationis, e.g. praepositio, shows actually traces of a certain reflection on syntax. The metaterminology used by grammarians to describe the mutual relation between linguistic elements seems to go even bey…
Per la storia delle Interpretationes Vergilianae di Tiberio Claudio Donato: dagli esemplari tardo antichi alla fase insulare e carolingia a Luxeuil
2013
Translations, versions and commentaries on poetry in the 15th- and 16th centuries
2020
This article introduces the monograph “Translations, versions and commentaries on poetry in the 15th- and 16th centuries”, which includes four studies dealing with translations from vernacular to vernacular, of works by Dante, Petrarch, Alain Chartier and Jan van der Noot.
Human Immunodeficiency Virus Continuum of Care in 11 European Union Countries at the End of 2016 Overall and by Key Population: Have We Made Progress?
2020
Abstract Background High uptake of antiretroviral treatment (ART) is essential to reduce human immunodeficiency virus (HIV) transmission and related mortality; however, gaps in care exist. We aimed to construct the continuum of HIV care (CoC) in 2016 in 11 European Union (EU) countries, overall and by key population and sex. To estimate progress toward the Joint United Nations Programme on HIV/AIDS (UNAIDS) 90-90-90 target, we compared 2016 to 2013 estimates for the same countries, representing 73% of the population in the region. Methods A CoC with the following 4 stages was constructed: number of people living with HIV (PLHIV); proportion of PLHIV diagnosed; proportion of those diagnosed …
Are we confident that final‐year medical students know at least basics about diabetes?: A preliminary report from the multicenter, survey‐based Diabe…
2021
Abstract Background We present the results of the pilot study of a multinational “Diabetes Know‐Me” project investigating knowledge regarding diabetes of medical students. This is the first collaborative project of the ISPAD JENIOUS group. Methods Students of the final year of medical studies from six countries answered a 25‐question survey regarding basic knowledge concerning diabetes (1091 surveys handed out, response rate 86%). Results Among the responders (58% female) 90% confirmed attending diabetology classes; 11% planned to specialize in diabetology. There were significant differences between countries in the median score of correct answers ranging from 10/25 to 22/25. Attending diab…
Human Immunodeficiency Virus Infection and Diverse Physical Health Outcomes: An Umbrella Review of Meta-analyses of Observational Studies.
2019
Abstract Background Our aim was to assess both the credibility and strength of evidence arising from systematic reviews with meta-analyses of observational studies and physical health outcomes associated with human immunodeficiency virus (HIV) but not acquired immunodeficiency syndrome. Methods We performed an umbrella review of observational studies. Evidence was graded as convincing, highly suggestive, suggestive, weak, or nonsignificant. Results From 3413 studies returned, 20 were included, covering 55 health outcomes. Median number of participants was 18 743 (range 403–225 000 000). Overall, 45 (81.8%) of the 55 unique outcomes reported nominally significant summary results (P < .05). O…
Experimental and theoretical evidence for bilayer-by-bilayer surface melting of crystalline ice
2017
On the surface of water ice, a quasi-liquid layer (QLL) has been extensively reported at temperatures below its bulk melting point at 273 K. Approaching the bulk melting temperature from below, the thickness of the QLL is known to increase. To elucidate the precise temperature variation of the QLL, and its nature, we investigate the surface melting of hexagonal ice by combining noncontact, surface-specific vibrational sum frequency generation (SFG) spectroscopy and spectra calculated from molecular dynamics simulations. Using SFG, we probe the outermost water layers of distinct single crystalline ice faces at different temperatures. For the basal face, a stepwise, sudden weakening of the hy…