Search results for "Common"
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Validation of the Walking Behavior Questionnaire (WBQ): A tool for measuring risky and safe walking under a behavioral perspective
2020
Abstract Introduction Although daily walking implies several potential benefits for the health and well-being of people, and, besides the raise of more “walkable” cities, it is currently being promoted as an active transportation means that is rich in benefits for its users, road risks affecting pedestrians, together with their high vulnerability to suffer severe injuries as a consequence of traffic crashes, have turned into a relevant concern for both policymakers and public health practitioners. In this regard, risky and positive (proactively safe) behaviors have acquired a substantial relevance for the study and prevention of traffic causalities involving different road users, including …
Predictors of visually induced motion sickness in women
2019
Abstract Background Visually induced motion sickness (VIMS) is commonly experienced when visual motion information is in conflict with motion information provided by the vestibular system and/or tactile and kinesthetic senses. According to some studies, women experience higher levels of VIMS than men, whereas other studies do not find this to be the case. Hypothesis This study investigated whether gender differences can be attributed to changes in VIMS-susceptibility due to the menstrual cycle and perceived menstrual pain. We hypothesized that higher perceived menstrual pain correlates positively with VIMS susceptibility. Methods We measured the influence of estimated concentrations of four…
The genomics of the human endometrium
2012
AbstractThe endometrium is a complex tissue that lines the inside of the endometrial cavity. The gene expression of the different endometrial cell types is regulated by ovarian steroids and paracrine-secreted molecules from neighbouring cells. Due to this regulation, the endometrium goes through cyclic modifications which can be divided simply into the proliferative phase, the secretory phase and the menstrual phase. Successful embryo implantation depends on three factors: embryo quality, the endometrium's state of receptivity, and a synchronised dialogue between the maternal tissue and the blastocyst. There is a need to characterise the endometrium's state of receptivity in order to preven…
Personality and Defence Mechanisms in Takotsubo Cardiomyopathy
2017
IntroductionTakotsubo cardiomyopathy (TC) is an acute cardiologic syndrome, characterized by specific symptoms and ECG, echocardiographic and enzymatic abnormalities, similar to an acute myocardial infarction, with no hemodynamically significant stenosis at coronary-ventriculography.ObjectiveTo assess personality in TC patients in order to find common psychopathological elements.MethodsA series of consecutive patients suffering from TC hospitalized at the Cardiology Unit of “Ingrassia” Hospital in Palermo in 2013–2014, were included in the study. We used Structured Clinical Interview for Axis I and II, according to DSM-IV TR criteria. Further, the Defense Mechanisms Inventory (DMI), used in…
Recurrent On-Duty Sleepiness and Alertness Management Strategies in Long-Haul Airline Pilots
2018
Introduction We examined whether long-haul airline pilots without recurrent on-duty sleepiness obtain more prior sleep and use more effective in-flight alertness management strategies than their colleagues with recurrent on-duty sleepiness. Methods There were 51 pilots who flew at least twice from Helsinki to Asia. Of them, 44 flew at least twice back to Helsinki following 1 local night. On-duty sleepiness was measured by the Karolinska Sleepiness Scale (KSS), alertness management strategies by a diary, and sleep by a diary and activity monitor. Pilots who rated KSS ≥ 7 on each, some, or none of the flights were classified as "regularly", "sometimes", and "never" sleepy, respectively. This …
Advances in detection and characterization of atherosclerosis using contrast agents targeting the macrophage
2006
With advances in imaging technology and our understanding of the role of inflammation in atherosclerosis, the macrophage appears to be an excellent target for imaging the progression of disease. In addition to imaging the macrophage with only 1 modality, contrast agents can be created that can be imaged with multiple modalities. This seems extremely attractive, as lesion morphology and characteristics can be determined with modalities that provide high picture resolution, such as CT or MRI, whereas macrophage quantity can be accurately determined through the creation of a radiolabeled contrast agent such as FDG via PET. Although this combination of imaging technologies may yield clinically …
High utilizers of medical care
2004
Abstract Objective Patients with somatoform disorders (SFD) are likely to overutilize healthcare services. This study investigates (a) whether extraordinarily high medical costs can be predicted from patient characteristics or psychopathology, and (b) whether high-utilizing patients respond differently to cognitive–behavioral treatment. Methods We compared 42 SFD high utilizers with 53 SFD average utilizers and 29 patients suffering from other than SFD mental disorders. High utilization was defined by healthcare expenditures of ≥€2500 during the past 2 years. Costs were computed from medical and billing records of health insurance companies. Somatization distress, hypochondriasis, depressio…
The association between quality of care and technical efficiency in long-term care
2005
To analyse the association between quality of care and technical (productive) efficiency in institutional long-term care wards for the elderly.One hundred and fourteen public health centre hospitals and residential homes in Finland.Wards were divided into two categories according to their rank in the quality distribution, considering 41 quality variables separately. The technical efficiency scores of the good- and poor-quality groups were compared using cross-sectional data.Data envelopment analysis was used for calculating technical efficiency. The Mann-Whitney test and correlation coefficients were used to explore the association between quality and efficiency.The wards where quality indi…
Innovation in Neurosurgery: The Concept of Cognitive Mapping
2019
In recent years, advances in cortical-subcortical mapping, intraoperative neurophysiology, and neuropsychology have increased the ability to remove intrinsic brain tumors, expanding indications and maximizing the extent of resection. This has provided a significant improvement in progression-free survival, time of malignant transformation (in low-grade gliomas), and overall survival. Although current techniques enable preservation of language and motor functions during surgery, the maintenance of a complex set of functions defined with the term cognition is not always achievable. Cognition is defined as every neural process underlying a high human function and includes motor haptic and visu…
α-secretase mediated conversion of the amyloid precursor protein derived membrane stub C99 to C83 limits Aβ generation
2009
The Swedish mutation within the amyloid precursor protein (APP) causes early-onset Alzheimer's disease due to increased cleavage of APP by BACE1. While beta-secretase shedding of Swedish APP (APPswe) largely results from an activity localized in the late secretory pathway, cleavage of wild-type APP occurs mainly in endocytic compartments. However, we show that liberation of Abeta from APPswe is still dependent on functional internalization from the cell surface. Inspite the unchanged overall beta-secretase cleaved soluble APP released from APP(swe) secretion, mutations of the APPswe internalization motif strongly reduced C99 levels and substantially decreased Abeta secretion. We point out t…