Search results for "Comparative"

showing 10 items of 1371 documents

Integrated CGH/WES Analyses Advance Understanding of Aggressive Neuroblastoma Evolution: A Case Study

2021

Neuroblastoma (NB) is the most common extra-cranial malignancy in preschool children. To portray the genetic landscape of an overly aggressive NB leading to a rapid clinical progression of the disease, tumor DNA collected pre- and post-treatment has been analyzed. Array comparative genomic hybridization (aCGH), whole-exome sequencing (WES), and pharmacogenetics approaches, respectively, have identified relevant copy number alterations (CNAs), single nucleotide variants (SNVs), and polymorphisms (SNPs) that were then combined into an integrated analysis. Spontaneously formed 3D tumoroids obtained from the recurrent mass have also been characterized. The results prove the power of combining C…

3D tumoroids; Array CGH; Clonal evolution; Neuroblastoma; Pharmacogenetics; Recurrent tumor; Single nucleotide variants; Whole exome sequencing; Child Preschool; Disease Progression; Drug Resistance Neoplasm; Fatal Outcome; Humans; Immunophenotyping; Neuroblastoma; Polymorphism Single Nucleotide; Comparative Genomic Hybridization; Whole Exome SequencingQH301-705.5Drug Resistanceclonal evolutionCase Report3D tumoroidsSingle-nucleotide polymorphismDiseaseComputational biologyBiologyMalignancyPolymorphism Single NucleotideSomatic evolution in cancerImmunophenotypingwhole exome sequencingNeuroblastomaFatal OutcomeNeuroblastomaExome SequencingmedicineHumansarray CGHrecurrent tumorPolymorphismBiology (General)ChildPreschoolExome sequencingTumorsComparative Genomic HybridizationSingle NucleotideGeneral Medicinemedicine.diseaseSingle nucleotide variantsDrug Resistance NeoplasmPharmacogeneticsChild PreschoolDisease ProgressionFarmacogenèticaNeoplasmPharmacogeneticsComparative genomic hybridization
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Suomen tiedontuotannon regiimi : yksi vai monta?

2021

Poliittisen talouden tutkimuksessa tapahtui 1990-luvulla niin kutsuttu ideakäänne. Viimeisen reilun vuosikymmenen aikana on alettu systemaattisesti tutkia ideoiden tuotantoa ja kanavointia poliittis-taloudelliseen päätöksentekoon. Vertailevan poliittisen talouden tutkimuksen piirissä on kehitetty tiedontuotannon regiimin teoria, joka tarkastelee tiedontuotannon institutionaalisia ja organisatorisia koneistoja, jotka tuottavat ideoita ja asiantuntijatietoa poliittis-taloudellista päätöksentekoa varten. Tämä artikkeli esittelee ja problematisoi tiedontuotannon regiimien tutkimusta. Artikkeli problematisoi tutkimuksen taustaoletusta regiimiin kuuluvien tiedontuottajien muodostaman organisaatio…

5171 Valtio-oppitiedontuotannon regiimitknowledge regimescomparative political economypoliittinen taloustiede5142 Sosiaali- ja yhteiskuntapolitiikkaSuomiproblematisointivertaileva poliittinen talousAlkuperäisartikkelitproblematizationtiedontuotantoFinland
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Teaching perspectives on CLIL in different educational contexts. Italy, Spain and Turkey

2020

La tesis realiza un estudio comparado internacional sobre el Aprendizaje Integrado de Contenidos y Lenguas Extranjeras (AICLE; en inglés Content and Language Integrated Learning, CLIL) basado en la impartición de diversas materias de una etapa educativa en inglés. El estudio se lleva a cabo en centros educativos de Italia, España y Turquía. El diseño de investigación utiliza un enfoque mixto cualtitativo-cualitativo, con cuestionarios y entrevistas en profundidad como herramientas de recolección de datos. Los datos de la investigación muestran la importancia de la colaboración del profesorado en cuanto a la creación de proyectos, el diseño de materiales, la planificación de las clases y la …

6303.03 MetodologíaEducational planningCLILEducación-PlanificaciónIntegrated learningComparative educationForeign languagesAprendizaje integradoLenguas extranjerasAICLEEuropeEnglish languageEducación comparadaCLIL Perception Foreign Language Teaching Content Teaching Diverse Educational Contexts5701.11 Enseñanza de LenguasInglésEuropaSettore M-PED/01 - Pedagogia Generale E Sociale
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Evolution and comparative genomics of di-symbiotic systems in aphids from the Lachninae subfamily and genome reduction in Serratia symbiotica

2016

Ph.D. thesis presented by Alejandro Manzano Marín Director: Prof. Dr. Amparo Latorre Castillo Institution: Universiat de València

:CIENCIAS DE LA VIDA::Simbiosis [UNESCO]BuchneraUNESCO::CIENCIAS DE LA VIDA::SimbiosisUNESCO::CIENCIAS DE LA VIDA::Microbiología ::Metabolismo bacterianoUNESCO::CIENCIAS DE LA VIDAcomparative genomicsgenome reduction:CIENCIAS DE LA VIDA::Microbiología ::Metabolismo bacteriano [UNESCO]symbiosisserratia symbiotica:CIENCIAS DE LA VIDA [UNESCO]
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Hacia la ley europea del clima: las evaluaciones científicas y el futuro papel de las respuestas jurídicas de los estados miembros

2021

Los problemas climáticos son temas persistentes y omnipresentes dentro de las políticas y legislaciones contemporáneas, que exigen un enfoque interdisciplinario para promover soluciones jurídicas adecuadas para la complejidad del tema. Paradójicamente, las propagandas negacionistas, lejos de bloquear las acciones climáticas, las han propiciado, lo que ha llevado al establecimiento de un organismo científico super partes que reconociese las cuestiones climáticas a través de informes científicos avanzados: el Grupo Intergubernamental de Expertos sobre el Cambio Climático de la ONU (IPCC). Desde entonces, muchos países han usado los hallazgos del IPCC como base científica para desarrollar polí…

:CIENCIAS JURÍDICAS [UNESCO]Cambio Climático; Ley Europea del Clima; Pacto Verde Europeo IPCC; Derecho Público Comparadoas well as on the role that EU Members States? legislations will play in facing climate issues. Cambio climáticoIPCC2070-8157 22082 Revista Boliviana de Derecho 584568 2021 32 8055237 Hacia la ley europea del clima las evaluaciones científicas y el futuro papel de las respuestas jurídicas de los estados miembros ViolaEuropean Climate Lawinstead of blocking climate actionsleading to the establishment of a super partes scientific body that has acknowledged climate issues through the most advanced scientific reports: the UN Intergovernmental Panel on Climate Change (IPCC). Since thenPublic Comparative Law. 758 773demanding an interdisciplinary approach to foster legal solutions suitable for the complexity of the subject. Paradoxicallyhave fostered themEU Green DealPasquale Climate issues are persistent and pervasive topics within contemporary policies and legislationsmany countries have adopted the findings of the IPCC as scientific basis for developing strategic policies and legislation with the aim of combining adaptation and mitigation efforts. To this extentmainly focusing on the IPCC scientific basis and the proposed EU regulation related to climate changePacto Verde Europeo IPCCUNESCO::CIENCIAS JURÍDICASPacto Verde EuropeoCambio ClimáticoDerecho Público Comparadothe EU Green Deal and the future European Climate Law exemplify such contemporary attitude. This essay analyses the aforementioned assumptionsClimate changeLey Europea del Climanegationist claimsthe UN Intergovernmental Panel on Climate Change (IPCC). Since then [leading to the establishment of a super partes scientific body that has acknowledged climate issues through the most advanced scientific reports]
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Las obras de Heiner Müller en torno a Shakespeare, reescritura paródica

2001

:LINGÜÍSTICA [UNESCO]Literature ComparativeUNESCO::LINGÜÍSTICA
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Genome and phenotype microarray analyses of rhodococcus sp. BCP1 and rhodococcus opacus R7: Genetic determinants and metabolic abilities with environ…

2015

In this paper comparative genome and phenotype microarray analyses of Rhodococcus sp. BCP1 and Rhodococcus opacus R7 were performed. Rhodococcus sp. BCP1 was selected for its ability to grow on short-chain n-alkanes and R. opacus R7 was isolated for its ability to grow on naphthalene and on o-xylene. Results of genome comparison, includ- ing BCP1, R7, along with other Rhodococcus reference strains, showed that at least 30% of the genome of each strain presented unique sequences and only 50% of the predicted proteome was shared. To associate genomic features with metabolic capabilities of BCP1 and R7 strains, hundreds of different growth conditions were tested through Phenotype Microarray, b…

AROMATIC-COMPOUNDS; GENUS RHODOCOCCUS; HIGH-THROUGHPUT; PATHWAY; DEGRADATION; BIODEGRADATION; EQUI; PERFORMANCE; CATABOLISMGenomics RhodococcusGene predictionBacterial Proteinlcsh:MedicineBiologyGenomeXenobioticsRhodococcus opacusBacterial ProteinsRhodococcuslcsh:ScienceGenePhylogenyGeneticsComparative genomicsMultidisciplinarylcsh:RMetabolic Networks and PathwayPhenotype microarrayHigh-Throughput Nucleotide SequencingRhodococcus sp. BCP1 Rhodococcus opacus R7Genome analysisGene Expression Regulation BacterialGenomicsSequence Analysis DNAbiology.organism_classificationBIO/19 - MICROBIOLOGIA GENERALEBiodegradation EnvironmentalPhenotypeProteomeGenomiclcsh:QPhenotype MicroarrayRhodococcusMetabolic Networks and PathwaysRhodococcuhydrocarbon degradationResearch Article
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Endovenous ablation of refluxing saphenous and perforating veins.

2017

Abstract. Since the end of the nineties endovenous thermal ablation and more recently non-thermal, non-tumescent techniques have been developed and improved. Until now, because of their favourable side effect profile in conjunction to sustained efficacy, in many countries they already replaced high ligation and stripping in the treatment of refluxing saphenous veins as well as for treatment of perforators and selected tributaries. Now, studies and comparative trials are available with long-term follow-ups for most of the techniques, providing valid data on occlusion and reflux rates, side effect profiles, and health related quality of life.

Ablation Techniquesmedicine.medical_specialtyTime FactorsSide effectRadiofrequency ablationThermal ablation030204 cardiovascular system & hematologylaw.invention030207 dermatology & venereal diseases03 medical and health sciences0302 clinical medicinePostoperative ComplicationslawRisk FactorsOcclusionMedicineHumansSaphenous VeinHealth related quality of lifebusiness.industryEndovenous ablationComparative trialSurgerySteamTreatment OutcomeVenous InsufficiencyCatheter AblationLaser TherapyPerforating veinsCardiology and Cardiovascular MedicinebusinessVASA. Zeitschrift fur Gefasskrankheiten
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Utilización de muestras clínicas para la investigación científica

2004


 SUMARIO: 1. Introducción. 2. Clasificación de las muestras con fundamento en criterios que afecten al régimen de su utilización para la investigación. 2.1. Clasificación de las muestras atendiendo a la posible identificación de su origen. 2.2. Otros tipos relevantes de clasificaciones de muestras clínicas. 3. Consentimiento informado en materia sanitaria y consentimiento para la utilización de datos personales. 3.1. Normas que aparentemente regulan la utilización de muestras para la docencia y la investigación. 3.2. Sentido y funcionalidad del consentimiento informado. 3.3. Remisión a la protección a la intimidad. 4. Algunas cuestiones jurídicas previas en orden a la determinación de…

Acceso a la informaciónlcsh:K1-7720lcsh:Law in general. Comparative and uniform law. Jurisprudencelcsh:International relationsGeneral Medicinelcsh:JZ2-6530
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False positive rate of an arrayCGH platform for single-cell preimplantation genetic screening and subsequent clinical application on day-3

2013

In this work, false positive rate of an arrayCGH platform for its use in day-3 single-blastomere analysis was calculated. For this purpose, 38 embryos diagnosed as abnormal on day-3 by FISH were re-biopsied on day-4. Single-cell day-4 arrayCGH diagnosis was then performed. A successful amplification was obtained in 97.4 % (37/38) of the day-4 cells analysed by arrayCGH. Day-3 FISH and day-4 arrayCGH diagnosis were concordant in 35/37 cases. The two discordant embryos were spread and all the cells from each embryo were re-analysed by FISH on day 5. The same error rate (2.7 %) for day-3 FISH and day-4 arrayCGH was obtained when comparing day-5 FISH re-analysis. After this pre-clinical phase, …

AdultBlastomeresmedicine.medical_specialtyTime FactorsPregnancy RateBiopsyConcordanceClinical pregnancyBiologySensitivity and SpecificityMiscarriagePregnancyarrayCGHDay-5 FISH re-analysisGeneticsmedicineChromosomes HumanHumansFalse Positive ReactionsEmbryo ImplantationGenetic TestingProspective StudiesIn Situ Hybridization FluorescenceGenetics (clinical)CryopreservationGynecologyComparative Genomic HybridizationReproducibility of ResultsObstetrics and GynecologyGeneral MedicineAneuploidyEmbryo Transfermedicine.diseaseBlastocystReproductive MedicineBlastomere biopsyBlastomere biopsyFish <Actinopterygii>Day-3 PGSFemaleFalse positive rateDevelopmental Biology
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