Search results for "Complement"

Functional Definition of a B Cell Epitope, KGEQGEPGA, on C1q the Fc-Binding Subunit of the First Component of Complement

1999

A synthetic peptide representing the C1q epitope KGEQGEPGA has been shown to suppress or delay the onset of CII-induced arthritis when applied intravenously (i.v.) prior to an intradermal (i.d.) challenge, in a mouse model; the phenomenon being associated with the development of immunoglobulin (Ig)M antibodies specific for the KGEQGEPGA epitope. Here we show that this amino acid sequence provides an immunodominant B cell epitope that is recognised by autoantibodies present in the sera of patients with chronic inflammatory diseases such as systemic lupus erythematosus (SLE) and rheumatoid arthritis, two diseases associated with an immune response to C1q. The peptide's ability to produce pept…

Pensiero aritmetico e pensiero algebrico in ambienti multiculturali: il caso cinese

2009

Spanish null complement anaphora at the grammar-discourse interface

2018

El estudio de la anáfora de complemento nulo (null complement anaphora, NCA, en inglés) es relevante en el estudio de la interfaz gramática-discurso, dado que parece materializar algunos de los procesos centrales otros fenómenos como por ejemplo la referencia, la anáfora, la elipsis, la inferencia, la prominencia o la acomodación. A pesar de que la NCA hasido estudiada en cantidad suficiente, todavía está vivo el debate sobre si se trata de un proceso de elipsis o anafórico. Este artículo contribuye a la consideración de la NCA como una anáfora profunda a partir de evidencias discursivas en español. Defendemos que la NCA es una anáfora que selecciona el antecedente más prominente en estruct…

On the social practice of indirect reports (further advances in the theory of pragmemes)

2010

Abstract This paper deals with the social practice of indirect reports and treats them as cases of language games. It proposes a number of principles like the following: Paraphrasis/Form Principle The that-clause embedded in the verb ‘say’ is a paraphrasis of what Y said, and meets the following constraints: should Y hear what X said he (Y) had said, he would not take issue with it, as to content, but would approve of it as a fair paraphrasis of his original utterance. Furthermore, he would not object to vocalizing the assertion made out of the words following the complementizer ‘that’ on account of its form/style. Furthermore, it connects such principles with Relevance Theory consideration…

The same (as what?)

2018

Aquest article adopta un enfocament radicalment contextualista en relació amb la referència de descripcions definides que contenen l?expressió anglesa the same, tant sense complement com amb complement en forma de nucli nominal i/o de sintagma comparatiu del tipus as X. S?argumenta que les descripcions definides que contenen the same no fan referència a una entitat única, encara que el resultat de la prova de comprensió efectuada sembla donar suport a la idea que aquestes descripcions poden afavorir la interpretació que aquests sintagmes definits es refereixen directament a una entitat específica.

Anti-inflammatory activity of berenjenol and related compounds.

2008

Berenjenol ( 1), isolated from OXANDRA cf. XYLOPIOIDES (Annonaceae), was tested on two different experimental models of inflammation. The compound showed anti-inflammatory activity in the test of acute mouse ear edema induced by TPA (54 % inhibition, 1 μmol/ear) as well as in the test of subchronic inflammation induced by repeated application of TPA (57 % inhibition, 7 × 1 μmol/ear). Moreover, while it reduced the expression of both COX-2 (65 % inhibition at 50 μM) and iNOS (80 % inhibition at 50 μM), it was not active against TNF- α and IL-1 β in murine macrophages (RAW 264.7) stimulated with LPS. Structural modification of 1 gave two derivatives, berenjenol acetate ( 2) and 3-oxo-berenjen…

Isolation and expression of a novel MBL-like collectin cDNA enhanced by LPS injection in the body wall of the ascidian Ciona intestinalis

2009

Collectins are a family of calcium-dependent lectins that are characterized by their collagen-like domains. Considerable interest has been focused on this class of proteins because of their ability to interact with components of the complement system activating a cascade of events responsible for the activation of the innate immune system. A differential screening between LPS-challenged and naïve Ciona intestinalis has been performed allowing the isolation of a full length cDNA encoding for a 221 AA protein. In silico analysis has shown that this polypeptide displays protein domains with similarities to mannose-binding lectins. A phylogenetic analysis suggested that C. intestinalis MBL has …

New functional ligands for ficolin-3 among lipopolysaccharides of Hafnia alvei.

2011

Ficolin-1 (M), ficolin-2 (L), ficolin-3 (H) and mannan-binding lectin (MBL) activate the complement system and have opsonic activity. The specificity of ficolin-3 is poorly characterized and currently limited to a few ligands only. We present new specific targets for human ficolin-3, identified among lipopolysaccharides (LPSs, endotoxin) of Hafnia alvei. The interaction was restricted to LPSs of four strains: 23, Polish Collection of Microorganisms (PCM) 1200, PCM 1203 and PCM 1205 and limited to their O-specific polysaccharides (O-specific PSs) composed of different numbers of oligosaccharide (OS) repeating units (RUs). Moreover, these LPS/ficolin-3 complexes activated the lectin pathway o…

COMPLEMENT-DEPENDENT B-CELL ACTIVATION BY COBRA VENOM FACTOR AND OTHER MITOGENS?

1974

It has been proposed that two distinct signals are required for the triggering of the precursors of antibody-forming bone marrow-derived cells (B cells): (a) the binding of antigen or of a mitogen to the corresponding receptor sites on B-cell membranes and (b) the interaction of activated C3 with the C3 receptor of B lymphocytes. There is growing evidence that B-cell mitogens and T (thymus-derived cell)-independent antigens are capable of activating the alternate pathway of the complement system (bypass). Therefore, the effect of another potent bypass inducer was investigated with regard to B-cell activation and the role of C3. Purified, pyrogen-free cobra venom factor was mitogenic for bot…

Cloning and expression of a novel component of the CAP superfamily enhanced in the inflammatory response to LPS of the ascidian Ciona intestinalis.

2010

The CAP superfamily is a group of proteins that have been linked to several biological functions such as reproduction, cancer, and immune defense. A differential screening between lipopolysaccharide (LPS)-challenged and naive Ciona intestinalis has been performed to identify LPS-induced genes. This strategy has allowed the isolation of a full-length 1471-bp cDNA encoding for a 413-amino-acid protein (CiCAP). In silico analysis has shown that this polypeptide displays a modular structure with similarities to vertebrate CAP-superfamily proteins and to a collagen-binding adhesin of Streptococcus mutans. Domain organization analysis and alignment of CiCAP to other vertebrate CAP proteins have r…