Search results for "Complement"
showing 10 items of 2113 documents
Grafici di funzione nella Scuola Primaria
2009
Il seguente articolo mostra i risultati di una sperimentazione didattica condotta in una quarta classe di Scuola Primaria relativa alla lettura e comprensione di grafici di funzioni. Le lezioni si sono svolte in assetto laboratoriale, facendo uso di un sensore di movimento. La nostra ricerca corrobora i precedenti lavori sugli strumenti MBL, secondo cui l’uso del sensore di movimento permette agli studenti di migliorare le competenze riguardanti la lettura, comprensione e interpretazione di grafici cinematici; inoltre mostra che l’utilizzo del sensore di movimento migliora tali competenze rispetto ad altri tipi di grafici, e in particolare, grafici di funzioni rappresentati fenomeni statist…
La nueva oportunidad de la hipoteca inversa
2021
The reverse mortgage is a credit or loan guaranteed by a mortgage that falls on the applicant?s habitual residence, granted at once, or through periodic benefits, to a person who must be over a certain age or prove a degree of disability or dependency, and is not due until the time of death. In view of the doubts that the future of the public pension is raising and the concentration of savings in Spanish property, the reverse mortgage is once again being put on the table as a viable alternative to complement a public pension with little revaluation, in view of the increase in life expectancy and expenses after retirement.
A tribute to Massimo Lanza de Cristoforis
2020
It is with great pleasure that we dedicate the special issue Functional Analytic Methods in Partial Differential Equations of Complex Variables and Elliptic Equations to the 60th birthday of Massim...
Analyse statistique implicative. Objet de recherche et de formation en analyse de données, outil pour la recherche multidisciplinaire
2010
El Análisis Factorial Exploratorio de los Ítems: una guía práctica, revisada y actualizada
2014
El Análisis Factorial Exploratorio es una de las técnicas más usadas en el desarrollo, validación y adaptación de instrumentos de medida psicológicos. Su uso se extendió durante los años 60 y ha ido creciendo de forma exponencial al ritmo que el avance de la informática ha permitido. Los criterios empleados en su uso, como es natural, también han evolucionado. Pero los investigadores interesados en asuntos sustantivos que utilizan rutinariamente esta técnica permanecen en muchos casos ignorantes de todo ello. En las últimas décadas numerosos trabajos han denunciado esta situación. La necesidad de actualizar los criterios clásicos para incorporar aquellos más adecuados es una necesidad urgen…
Rivalutazione ad un anno di ANA e complementemia in personale afferente ad un laboratorio di chimica organica esposto a solventi.
2008
Isopetasin and S-isopetasin as novel P-glycoprotein inhibitors against multidrug-resistant cancer cells
2019
Abstract Background A major problem of cancer treatment is the development of multidrug resistance (MDR) to chemotherapy. MDR is caused by different mechanisms such as the expression of the ABC-transporters P-glycoprotein (P-gp, MDR1, ABCB1) and breast cancer resistance protein (BCRP, ABCG2). These transporters efflux xenobiotic toxins, including chemotherapeutics, and they were found to be overexpressed in different cancer types. Purpose Identification of novel molecules that overcome MDR by targeting ABC-transporters. Methods Resazurin reduction assay was used for cytotoxicity test. AutoDock 4.2. was used for molecular docking. The function of P-gp and BCRP was tested using a doxorubicin …
Collateral sensitivity of drug-resistant ABCB5- and mutation-activated EGFR overexpressing cells towards resveratrol due to modulation of SIRT1 expre…
2019
Abstract Background In the drug discovery field, natural products deemed a precious source of novel lead compounds. They have the ability to bypass or overcome multidrug resistance (MDR) in cancer cells. Purpose In this study, the natural polyphenolic stilbene resveratrol (RES) has been studied for its cytotoxic activity toward MDR cancer cells. Methods Resazurin assay was used to investigate the cytotoxicity of RES not only against a panel of drug-resistant cancer cells overexpressing P-glycoprotein/ABCB1, BCRP/ABCG2, ABCB5 (ATP-binding cassette transporters), but also mutation-activated EGFR. The assessment of proteins expression was done by Western blot analysis. COMPARE and hierarchical…
Nitensidine A, a guanidine alkaloid from Pterogyne nitens, is a novel substrate for human ABC transporter ABCB1.
2014
The Pterogyne nitens (Fabaceae) tree, native to South America, has been found to produce guanidine alkaloids as well as bioactive flavonols such as kaempferol, quercetin, and rutin. In the present study, we examined the possibility of interaction between human ATP-binding cassette (ABC) transporter ABCB1 and four guanidine alkaloids isolated from P. nitens (i.e., galegine, nitensidine A, pterogynidine, and pterogynine) using human T cell lymphoblast-like leukemia cell line CCRF-CEM and its multi-drug resistant (MDR) counterpart CEM/ADR5000. In XTT assays, CEM/ADR5000 cells were resistant to the four guanidine alkaloids compared to CCRF-CEM cells, although the four guanidine alkaloids exhibi…
The lignan, (-)-sesamin reveals cytotoxicity toward cancer cells: pharmacogenomic determination of genes associated with sensitivity or resistance.
2013
(-)-Sesamin is a lignan present in sesam oil and a number of medicinal plants. It exerts various pharmacological effects, such as prevention of hyperlipidemia, hypertension, and carcinogenesis. Moreover, (-)-sesamin has chemopreventive and anticancer activity in vitro and in vivo. Multidrug resistance (MDR) of tumors leads to fatal treatment outcome in many patients and novel drugs able to kill multidrug-resistant cells are urgently needed. P-glycoprotein (MDR1/ABCB1) is the best known ATP-binding cassette (ABC) drug transporter mediating MDR. ABCB5 is a close relative to ABCB1, which also mediates MDR. We found that the mRNA expressions of ABCB1 and ABCB5 were not related to the 50% inhibi…