Search results for "Complex."
showing 10 items of 5824 documents
Oral Glycoprotein IIb/IIa Antagonists for Unstable Angina — Is There Still a Chance for the Oral Substances?
2001
The intravenous glycoprotein IIb/IIIa antagonists abciximab, tirofiban and eptifibatide are well accepted for the therapy of patients with unstable angina and/or as concomitant medication during coronary interventions. Despite the fact that these drugs are not used in all patients presenting with unstable angina during coronary interventions, the scientific evidence is overwhelming including the substantial reduction in mortality 3 years after utilisation of abciximab for coronary interventions in patients with unstable angina. In addition to these two indications, intravenous glycoprotein IIb/IIIa antagonists are currently being investigated for use in patients undergoing carotid artery in…
Mitochondrial compartment: a possible target of cadmium effects on breast epithelial cells.
2009
Cadmium–breast epithelial cell interactions were studied by analyzing some mitochondria-related aspects of stress response. We treated immortalized non-tumor breast cells with 5 or 50 μM CdCl2 for 24 or 96 h demonstrating that the exposure did not cause a significant mitochondrial proliferation, while it induced a significant increase in the respiratory activity and mitochondrial polarization. In addition, we found that hsp60 was up-regulated while hsp70 and COXII and COXIV were down-regulated. The mRNA for hsp70 remained constant and only the inducible form of the 70-kDa heat shock protein was over expressed. The mRNAs for COXII and COXIV remained constant after 24 h and increased after lo…
Co-morbidity does not reflect complexity in internal medicine patients
2006
Internal medicine patients are mostly elderly; they have multiple co-morbidities, which are usually chronic, rather than self-limiting or acute diseases. Neither administrative indicators nor co-morbidity indexes, though validated in elderly patients, are able to completely define these "complex" patients or to allow physicians to correctly "cope" with them. For the complex patients found in internal medicine wards, internists need not only to find the best diagnosis and treatment, but also to apply a complex intervention (i.e., a comprehensive assessment and both continuous and multi-disciplinary care) in order to maintain their health and ability to function and to prevent or delay disabi…
Premature diagnostic closure: An avoidable type of error
2013
A well-developed clinical interview makes it possible to adequately focus the diagnosis. However, cognitive psychology shows that mistakes are made when the persons face complex problems, such as those faced when making a diagnosis, especially if time or resources are limited. The main cause of failures in clinical reasoning is using "cognitive shortcuts". Among them, premature closure is a key factor triggering a diagnostic error. Cognitive errors are predictable and thus, it is possible to learn strategies to reduce or avoid them. Knowing the main features of cognitive shortcuts and identifying those automatically used is the first step towards preventing errors or minimizing their conseq…
Singular solutions to p-Laplacian type equations
1999
We construct singular solutions to equations $div\mathcal{A}(x,\nabla u) = 0,$ similar to the p-Laplacian, that tend to ∞ on a given closed set of p-capacity zero. Moreover, we show that every Gδ-set of vanishing p-capacity is the infinity set of some A-superharmonic function.
A numerical model of the cloud-topped planetary boundary-layer: Impact of aerosol particles on the radiative forcing of stratiform clouds
1997
In a numerical sensitivity study, the microphysical model of stratus MISTRA, is used to investigate the impact of aerosol particles on the evolution of stratiform clouds. Four model runs are presented, each for a different type of background aerosol. Two include aerosol particle size-distributions which are typical of marine and rural continental air masses; a third represents a mixture of marine and rural continental aerosol particles, and the fourth rural continental aerosol particles with a reduced solubility in water. The results show that the microphysical structure of layer clouds was strongly affected by the physico-chemical properties of the aerosol particles from which the cloud dr…
A numerical model of the cloud-topped planetary boundary-layer: radiative forcing of aerosols in stratiform clouds
1998
In a numerical sensitivity study with the microphysical stratus model MISTRA the impact of aerosol particles on the time evolution of stratiform clouds is investigated. Four model runs with different aerosol size distributions are presented. Two size distributions are typical for maritime and continental air masses. The third model run consists of a mixture of maritime and rural aerosol particles, while in the fourth case study rural aerosol particles with a reduced water solubility are utilized. The numerical results show that the microphysical structure of the clouds is strongly affected by the physico-chemical properties of the aerosol particles. In the maritime case, with a relatively l…
A local complexity based combination method for decision forests trained with high-dimensional data
2012
Accurate machine learning with high-dimensional data is affected by phenomena known as the “curse” of dimensionality. One of the main strategies explored in the last decade to deal with this problem is the use of multi-classifier systems. Several of such approaches are inspired by the Random Subspace Method for the construction of decision forests. Furthermore, other studies rely on estimations of the individual classifiers' competence, to enhance the combination in the multi-classifier and improve the accuracy. We propose a competence estimate which is based on local complexity measurements, to perform a weighted average combination of the decision forest. Experimental results show how thi…
Calcification is not the Achilles' heel of cold-water corals in an acidifying ocean
2015
Ocean acidification is thought to be a major threat to coral reefs: laboratory evidence and CO2 seep research has shown adverse effects on many coral species, although a few are resilient. There are concerns that cold-water corals are even more vulnerable as they live in areas where aragonite saturation (?ara) is lower than in the tropics and is falling rapidly due to CO2 emissions. Here, we provide laboratory evidence that net (gross calcification minus dissolution) and gross calcification rates of three common cold-water corals, Caryophyllia smithii, Dendrophyllia cornigera, and Desmophyllum dianthus, are not affected by pCO2 levels expected for 2100 (pCO2 1058 ?atm, ?ara 1.29), and nor a…
Effect of kind and content of organo-modified clay on properties of PET nanocomposites
2011
In this work we report the properties of nanocomposite based on PET with two different samples of organically modified montmorillonites. In particular, we studied the effect of the filler concentration on morphology, rheology, and mechanical performance, focusing our attention on the effect of the degradation phenomena of the clay modifiers. The results indicate that at low clay level the morphology achieved is mainly intercalated. On increasing the filler level, coalescence and/or bad defragmentation phenomena induce a coarser morphology, as confirmed by XRD, SEM, and TEM observations. When a more polar organic modifier is used to modify the clay, the particle adhesion and distribution is …