Search results for "Complex."
showing 10 items of 5824 documents
Synthesis and studies of new optimised chelating agents for targeting chemokine receptor CXCR4
2012
The objective of this thesis work was to develop CXCR4-targeted tools to localize and treat cancer at an early stage. In this line, we investigated the synthesis of new target-specific radiopharmaceuticals. The work focused on two main axes, i.e. the chelating agent and the carrier, by using the know-how and the expertise of our group in polyazacycloalkanes synthesis and functionalization. In the first part, we were interested in developing new macrocyclic scaffolds of high potential for copper and gallium chelation. We first focused on the development of a new powerful route towards selectively functionalized constrained homocyclens. The second part was based on C-functionalized 1,4,7-tria…
Chemical speciation of nucleotide 5′-monophosphates in the presence of biogenic amines
2001
The interaction of adenosine-, uridine-, inosine- and guanosine-5’-monophosphates with protonated ethylenediamine, putrescine, cadaverine, spermidine and spermine, was studied potentiometrically, a...
Interactions of Dioxouranium(VI) with Amines in Aqueous Solution
2010
The interaction of the dioxouranium(VI) ion with five low molecular weight polyamines (ethylenediamine, putrescine, cadaverine, spermidine, and spermine) and with poly(allyl)amine (15 kDa) was studied potentiometrically (ISE-H + glass electrode) at T ) 298.15 K. Investigations were carried out in NaNO3 ionic medium, at I ) 0.1 mol · L -1 (and 0.5 mol · L -1 for poly(allyl)amine only), in the pH range 3.5 to 5.5, before the formation of uranyl insoluble species. The results gave evidence for the formation of two species, namely, UO2L 2+ and UO2L(OH) + for the diamine systems (ethylenediamine, putrescine, cadaverine), UO2L 2+ and UO2LH 3+ for spermidine, and UO2LH 3+ and UO2LH2 4+ for spermin…
Formation and Stability of Cadmium(II)/Phytate Complexes by Different Electrochemical Techniques. Critical Analysis of Results
2010
In the present work the stability constants of various cadmium(II)/phytate (Phy) species were determined at T = 298.15 K in NaNO3(aq) at I = 0.1 mol·L−1 by DP-ASV (Differential Pulse Anodic Stripping Voltammetry) and by potentiometric titrations using an ISE-Cd2+. Cyclic voltammograms were also recorded to check the electrochemical behavior of cadmium in the presence of phytate. The results were analyzed together with previous data determined by ISE-H+ measurements. Data obtained were used to provide an exhaustive speciation scheme for the phytate/cadmium(II) system at different conditions, as well as a comprehensive representation of the binding ability of phytate toward cadmium(II). Diffe…
Environmental cadmium, lead and nickel contamination: possible relationship between soil and vegetable content
1991
The cadmium, lead and nickel content of soils of four agricultural areas exposed to different degrees of environmental pollution and vegetables grown there were measured by Atomic Absorption Spectrophotometry (AAS). In order to ascertain the possible relationship between the heavy metal content of soils (total and extractable) and of vegetables grown in them, the correlation between the two was calculated. The highest correlation values between metal content of soil and vegetables are these corresponding to nickel: the total metal content in soils and leaves-stems are linear (p<0.01). The extractable metal content of soils and leaves-stems are linear (p<0.1). Therefore, soil seems to be the…
Well-posedness and singularity formation for the Camassa-Holm equation
2006
We prove the well-posedness of Camassa--Holm equation in analytic function spaces both locally and globally in time, and we investigate numerically the phenomenon of singularity formation for particular initial data.
X Chromosome Contribution to the Genetic Architecture of Primary Biliary Cholangitis
2021
Background & aims: Genome-wide association studies in primary biliary cholangitis (PBC) have failed to find X chromosome (chrX) variants associated with the disease. Here, we specifically explore the chrX contribution to PBC, a sexually dimorphic complex autoimmune disease. Methods: We performed a chrX-wide association study, including genotype data from 5 genome-wide association studies (from Italy, United Kingdom, Canada, China, and Japan; 5244 case patients and 11,875 control individuals). Results: Single-marker association analyses found approximately 100 loci displaying P < 5 × 10-4, with the most significant being a signal within the OTUD5 gene (rs3027490; P = 4.80 × 10-6; odds…
HLA class I antigen abnormalities and immune escape by malignant cells
2002
Abbreviations used in this paper: APM, antigen processing machinery; β2m,β2 microglobulin; bp, base pair; CTL, cytotoxic T lymphocytes; ER, endoplasmic reticulum; HC, heavy chain; HNSCC, head and neck squamous cell carcinoma; IFN, interferon; IL, interleukin; KIR, killing inhibitory receptors; LMP, low molecular weight proteins; LOH, loss of heterozygosity; mAb, monoclonal antibody; MHC, major histocompatibility complex; NK, natural killer; PA, proteasome activator; PCR, polymerase chain reaction; RCC, renal cell carcinoma; SCLC, small cell-lung carcinoma; TAA, tumor-associated antigens; TAP, transporter associated with antigen processing; TCR, T cell receptor; TNF, tumor necrosis factor; w…
Induction of tumor-cell lysis by bi-specific antibody recognizing ganglioside GD2 and T-cell antigen CD3
1993
Human tumor cells expressing ganglioside GD2 were lysed by various effector populations targeted with an anti-CD3-anti-GD2 bi-specific antibody (BAb CD3 x GD2). This antibody-heteroconjugate was prepared by chemically cross-linking the OKT-3 monoclonal antibody (MAb) reactive with CD3 antigen on T lymphocytes with the ganglioside MAb ME 361, which binds preferentially to the tumor-associated ganglioside GD2. The specificity of target-cell lysis by the cytotoxic T cells (CTL) was mediated by the specificity of the targeting antibody: GD2-negative cells were not lysed in the presence of the CD3 x GD2 BAb. A dose-dependent response was observed in a range of 10 to 10,000 ng/ml. In contrast, 2 …
Dual regulation of SPI1/PU.1 transcription factor by heat shock factor 1 (HSF1) during macrophage differentiation of monocytes
2014
International audience; : In addition to their cytoprotective role in stressful conditions, heat shock proteins (HSPs) are involved in specific differentiation pathways, e.g. we have identified a role for HSP90 in macrophage differentiation of human peripheral blood monocytes exposed to Macrophage Colony-Stimulating Factor (M-CSF). Here, we show that deletion of the main transcription factor involved in heat shock gene regulation, heat shock factor 1 (HSF1), affects M-CSF-driven differentiation of mouse bone marrow cells. HSF1 transiently accumulates in the nucleus of human monocytes undergoing macrophage differentiation, including M-CSF-treated peripheral blood monocytes and phorbol ester-…