Search results for "Complexes"
showing 10 items of 875 documents
Water oxidation catalyzed by molecular di- and nonanuclear Fe complexes: importance of a proper ligand framework.
2016
The synthesis of two molecular iron complexes, a dinuclear iron(III,III) complex and a nonanuclear iron complex, based on the di-nucleating ligand 2,2-(2-hydroxy-5-methyl-1,3-phenylene)bis(1H-benzo[d]imidazole-4-carboxylic acid) is described. The two iron complexes were found to drive the oxidation of water by the one-electron oxidant [Ru(bpy)(3)](3+). Funding Agencies|Knut and Alice Wallenberg Foundation; Swedish Research Council [621-2013-4872]; Carl Trygger Foundation; DFG (Metal Sites in Biomolecules: Structures, Regulation and Mechanisms) [IRTG 1422]; Swedish Energy Agency
New heteronuclear gold(I)-platinum(II) complexes with cytotoxic properties: are two metals better than one?
2014
A series of mono- and heterodinuclear gold(I) and platinum(II) complexes with a new bipyridylamine-phosphine ligand have been synthesized and characterized. The X-ray structures of the ligand precursor 4-iodo-N,N-di(pyridin-2-yl)benzamide, and of one gold derivative are reported. All the complexes display antiproliferative properties in vitro in human cancer cells in the range of cisplatin or higher, which appear to correlate with compounds' uptake. Interestingly, studies of the interactions of the compounds with models of DNA indicate different mechanisms of actions with respect to cisplatin. The biological activity study of these complexes provides useful information about the interest of…
Metal complexes of oxadiazole ligands: An overview
2019
Oxadizoles are heterocyclic ring systems that find application in different scientific disciplines, from medicinal chemistry to optoelectronics. Coordination with metals (especially the transition ones) proved to enhance the intrinsic characteristics of these organic ligands and many metal complexes of oxadiazoles showed attractive characteristics for different research fields. In this review, we provide a general overview on different metal complexes and polymers containing oxadiazole moieties, reporting the principal synthetic approaches adopted for their preparation and showing the variety of applications they found in the last 40 years.
Flow-chemiluminescence: a growing modality of pharmaceutical analysis.
2001
The present article deals with a review of the applications of the chemiluminescence to pharmaceutical analyses by using continuous-flow assemblies. A comprehensive study on the fundamentals of the chemiluminescence is also included.
Interaction between heterobinuclear molecules and nature of the ground spin state in oximato-bridged [CuIIMII]2 bis-binuclear complexes (M=Cu, Ni, Mn…
1999
[EN] Two new heterobimetallic complexes [Cu(pdmg)Ni(Me-3[12]N-3)(CH3CH2OH)](ClO4)(2)(2) and [Cu(pdmg) Mn(bipy)(2)]-ClO4)(2) . H2O (3) (H(2)pdmg = 3,9-dimethyl-4,8-diazaundeca-3,8-diene-2 10-dione dioxime; Me-3[12]N-3 = 2,4,4-trimethyl-1,5,9-triazacyclododeca-1-ene; bipy = 2,2'-bipyridyl) have been prepared and characterized. The structure of 2 has been determined by single-crystal X-ray diffraction methods. It consists of [Cu(pdmg)Ni(Me-3[12]N-3)(CH3CH2OH)](2+) cations and non-coordinated perchlorate anions. The [Cu(pdmg)(CH3CH2OH)] complex coordinates to the [Ni(Me-3[12]N-3)](2+) fragment to afford the binuclear unit doubly-bridged by oximato groups in cis arrangement. The coordination geo…
Synthesis and structural characterisation of germanium(II) halide complexes with neutral N-donor ligands.
2010
The Ge(II) complexes [GeX(2)(L-L)] (L-L = 1,10-phen (X = Cl, Br); L-L = Me(2)N(CH(2))(2)NMe(2), 2,2'-bipy (X = Cl)), [GeX(L-L)][GeX(3)] (L-L = 2,2'-bipy (X = Br); L-L = pmdta (MeN(CH(2)CH(2)NMe(2))(2)) (X = Cl, Br)) have been prepared and their crystal structures determined. The crystal structure of [GeCl(2){Me(2)N(CH(2))(2)NMe(2)}] shows a weakly associated centrosymmetric dimer based upon distorted square-pyramidal coordination at Ge(II) and containing asymmetrically chelating diamine ligands. The structure of [GeCl(2)(2,2'-bipy)] contains a chelating 2,2'-bipy ligand and forms a zig-zag chain polymer via long-range intermolecular Ge...Cl bridging interactions, leading to a very distorted…
"DEVELOPMENT OF A DECISION SUPPORT SYSTEM FOR BIOINFORMATICS. EXTRACTION OF PROTEIN COMPLEXES FROM A PROTEIN-PROTEIN INTERACTION NETWORK: A CASE STUD…
2011
Decision Support Systems and Workflow Management Systems have become essential tools for some business and scientific field. This thesis propose a new hybrid architecture for problem solving expertise and decision-making process, that aims to support high-quality research in the field of bioinformatics and system biology. The first part of the dissertation introduces the project to which belong this thesis work, i.e. the “Bioinformatics Organized Resources - an Intelligent System” (BORIS) project of the ICAR-CNR; the main goal of BORIS is to provide an helpful and effective support to researchers or experimentalist, that have no familiarity with tools and techniques to solve computational p…
Reorganization of Nuclear Pore Complexes and the Lamina in Late-Stage Parvovirus Infection
2015
Article
Htid-1, the human homolog of the Drosophila melanogaster l(2)tid tumor suppressor, defines a novel physiological role of APC.
2007
Htid-1, the human counterpart of the Drosophila tumor suppressor gene lethal(2)tumorous imaginal discs (l(2)tid) encodes three splice forms translated into three cytosolic - Tid50, Tid48 and Tid46 - and three mitochondrial - Tid43, Tid40 and Tid38 - proteins. Here we provide evidence for the association of the endogenous Tid50/Tid48 proteins with the adenomatous polyposis coli (APC) tumor suppressor in normal colon epithelium, colorectal cancer cells and mouse NIH3T3 fibroblasts. Using the Glutathione S-transferase binding assay we show that the N-terminal region including the Armadillo domain (ARM) of APC is sufficient to bind the Tid molecules. Using immunoprecipitation and confocal micro…
The Impact of Humic Substances as Remediation Agents to the Speciation Forms of Metals in Soil
2013
Abstract Humic substances (HS) are the most widespread group of organic substances in natural environment and have high stability. The main terrestrial reserves are found in the form of naturally occurring ore, peat or lignite. The aim of this paper is to study possibilities to use HS as agents for remediation of contaminated with heavy metals soil and impacts of HS of metal speciation forms in it. It has been proved that HS are able to bind to metal ions and change their speciation forms in soils. The ability to form complexes with metal ions depends on the type of soil, type of metal, as well as concentrations of HS in soil. The study was carried out in experimental conditions and analyti…