Search results for "Component"
showing 10 items of 1682 documents
Scalable Monitoring System for Clouds
2013
Although cloud computing has become an important topic over the last couple of years, the development of cloud-specific monitoring systems has been neglected. This is surprising considering their importance for metering services and, thus, being able to charge customers. In this paper we introduce a monitoring architecture that was developed and is currently implemented in the EASI-CLOUDS project. The demands on cloud monitoring systems are manifold. Regular checks of the SLAs and the precise billing of the resource usage, for instance, require the collection and converting of infrastructure readings in short intervals. To ensure the scalability of the whole cloud, the monitoring system mus…
Comprehensive System for Systematic Case-Driven Software Reuse
2010
Reuse of software artifacts (blueprints and code) is normally associated with organising a systematic reuse framework most often constructed for a specific problem domain. In this paper we present a system (language, tool, reuse process) where software reuse is based on building and retrieving of so-called software cases (large compound artifacts) that can be reused between domains. The system is opportunistic in that software cases result from usual (non-reuse oriented) activities where also semantic information is added. This information is used to support regular development but may serve later to retrieve software cases. Having this common semantic basis, we can organise a systematic cr…
A framework for data quality handling in enterprise service bus
2013
Enterprise Service Bus (ESB) is proposed to address the application integration problem by facilitating communication among different systems in a loosely coupled, standard-based, and protocol independent manner. Data sources are maintained out of the ESB's control and there should be a mechanism to select the most suitable data source among all available data sources. Especially, when two or more data sources are about the same object. For instance, it is normal to use more than one sensor to measure pressure or temperature at a particular point. Data quality can play an important role in selecting data sources in ESB since quality of data is an essential factor in the success of organizat…
Principal component analysis on molecular descriptors as an alternative point of view in the search of new Hsp90 inhibitors
2009
Inhibiting a protein that regulates multiple signal transduction pathways in cancer cells is an attractive goal for cancer therapy. Heat shock protein 90 (Hsp90) is one of the most promising molecular targets for such an approach. In fact, Hsp90 is a ubiquitous molecular chaperone protein that is involved in folding, activating and assembling of many key mediators of signal transduction, cellular growth, differentiation, stress-response and apoptothic pathways. With the aim to analyze which molecular descriptors have the higher importance in the binding interactions of these classes, we first performed molecular docking experiments on the 187 Hsp90 inhibitors included in the BindingDB, a pu…
Increasing the Coverage of Medicinal Chemistry-Relevant Space in Commercial Fragments Screening
2014
Analyzing the chemical space coverage in commercial fragment screening collections revealed the overlap between bioactive medicinal chemistry substructures and rule-of-three compliant fragments is only ∼25%. We recommend including these fragments in fragment screening libraries to maximize confidence in discovering hit matter within known bioactive chemical space, while incorporation of nonoverlapping substructures could offer novel hits in screening libraries. Using principal component analysis, polar and three-dimensional substructures display a higher-than-average enrichment of bioactive compounds, indicating increasing representation of these substructures may be beneficial in fragment …
Genomic determinants of speciation and spread of the Mycobacterium tuberculosis complex
2019
14 páginas, 6 figuras
ELECTRE III to dynamically support the decision maker about the periodic replacements configurations for a multi-component system
2013
The problem tackled by the present paper concerns the selection of the elements of a repairable and stochastically deteriorating multi-component system to replace (replacements configuration) during each scheduled and periodical system stop within a finite optimization cycle, by ensuring the simultaneous minimization of both the expected total maintenance cost and the system unavailability. To solve the considered problem, a combined approach between multi-objective optimization problem (MOOP) and multi-criteria decision making (MCDM) resolution techniques is proposed. In particular, the @e constraint method is used to single out the optimal Pareto frontier whereas the ELECTRE III multi-cri…
Optimal extension of multispectral image demosaicking algorithms for setting up a one-shot camera video acquisition system
2022
Multispectral images are acquired using multispectral cameras equipped with CCD or CMOS sensors which sample the visible or near infrared spectrum according to specific spectral bands. A mosaic of multispectral MSFA filters is superimposed on the surface of the sensors to acquire a raw image called an MSFA image. In the MSFA image, only one spectral band is available per pixel, the demosaicking process is necessary to estimate the multispectral image at full spatio-spectral resolution. Motivated by the success of single-sensor cameras capturing the image in a single exposure that use CFA filters, we performed a comparative study of a few recent color image demosaicking algorithms and experi…
Space-Time FPCA Clustering of Multidimensional Curves.
2018
In this paper we focus on finding clusters of multidimensional curves with spatio-temporal structure, applying a variant of a k-means algorithm based on the principal component rotation of data. The main advantage of this approach is to combine the clustering functional analysis of the multidimensional data, with smoothing methods based on generalized additive models, that cope with both the spatial and the temporal variability, and with functional principal components that takes into account the dependency between the curves.
Ultra-high performance liquid chromatography-quadrupole time-of-flight mass spectrometry to identify contaminants in water: an insight on environment…
2013
Ultra-high pressure liquid chromatography-quadrupole time-of-flight mass spectrometry (UHPLC-QqTOF-MS) acquiring full scan MS data for quantification, and automatic data dependent information product ion spectra (IDA-MS/MS) without any predefinition of the ions by the user was checked for identifying organic contaminants in water samples. The use of a database with more than 2000 compounds achieved high confidence results for a wide number of contaminants based upon retention time, accurate mass, isotopic pattern and MS/MS library searching. More than 20 contaminants, mostly pharmaceuticals, but also mycotoxins and polyphenols were unambiguously identified. Furthermore, the combination of s…