Search results for "Computer Science Application"
showing 10 items of 3998 documents
RIP-Chip analysis supports different roles for AGO2 and GW182 proteins in recruiting and processing microRNA targets.
2019
Background MicroRNAs (miRNAs) are small non-coding RNA molecules mediating the translational repression and degradation of target mRNAs in the cell. Mature miRNAs are used as a template by the RNA-induced silencing complex (RISC) to recognize the complementary mRNAs to be regulated. To discern further RISC functions, we analyzed the activities of two RISC proteins, AGO2 and GW182, in the MCF-7 human breast cancer cell line. Methods We performed three RIP-Chip experiments using either anti-AGO2 or anti-GW182 antibodies and compiled a data set made up of the miRNA and mRNA expression profiles of three samples for each experiment. Specifically, we analyzed the input sample, the immunoprecipita…
Topological structure analysis of chromatin interaction networks.
2019
Abstract Background Current Hi-C technologies for chromosome conformation capture allow to understand a broad spectrum of functional interactions between genome elements. Although significant progress has been made into analysis of Hi-C data to identify biologically significant features, many questions still remain open, in particular regarding potential biological significance of various topological features that are characteristic for chromatin interaction networks. Results It has been previously observed that promoter capture Hi-C (PCHi-C) interaction networks tend to separate easily into well-defined connected components that can be related to certain biological functionality, however, …
The Evolving Role of Fetuin-A in Nonalcoholic Fatty Liver Disease: An Overview from Liver to the Heart
2021
Nonalcoholic fatty liver disease (NAFLD) is strongly associated to the features of metabolic syndrome which can progress to cirrhosis, liver failure and hepatocellular carcinoma. However, the most common cause of mortality in people with NAFLD is not liver-related but stems from atherosclerotic cardiovascular disease (CVD). The prevalence of NAFLD is on the rise, mainly as a consequence of its close association with two major worldwide epidemics, obesity and type 2 diabetes (T2D). The exact pathogenesis of NAFLD and especially the mechanisms leading to disease progression and CVD have not been completely elucidated. Human fetuin-A (alpha-2-Heremans Schmid glycoprotein), a glycoprotein produ…
Fotovoz como metodología innovadora en educación superior
2022
La adaptación al EEES ha exigido el surgimiento de metodologías activas adscritas a la educación, siendo fotovoz clave en diferentes niveles educativos. Sin embargo, la investigación en el contexto educativo, y en concreto en el de Educación Superior, es escaso. Por tanto, el objetivo de este trabajo es analizar el uso de fotovoz en educación superior, a través de una revisión sistemática basada en la Declaración PRISMA 2020 en tres bases de datos. Quince de los 408 estudios identificados cumplieron con los criterios de inclusión. Los resultados posicionan Fotovoz como una alternativa educativa con potencial en entornos de Educación Superior. The adaptation to the EHEA has demanded the emer…
On Duality in Learning and the Selection of Learning Teams
1996
AbstractPrevious work in inductive inference dealt mostly with finding one or several machines (IIMs) that successfully learn collections of functions. Herein we start with a class of functions and considerthe learner setof all IIMs that are successful at learning the given class. Applying this perspective to the case of team inference leads to the notion ofdiversificationfor a class of functions. This enable us to distinguish between several flavours of IIMs all of which must be represented in a team learning the given class.
Positive Versions of Polynomial Time
1998
Abstract We show that restricting a number of characterizations of the complexity class P to be positive (in natural ways) results in the same class of (monotone) problems, which we denote by posP . By a well-known result of Razborov, posP is a proper subclass of the class of monotone problems in P . We exhibit complete problems for posP via weak logical reductions, as we do for other logically defined classes of problems. Our work is a continuation of research undertaken by Grigni and Sipser, and subsequently Stewart; indeed, we introduce the notion of a positive deterministic Turing machine and consequently solve a problem posed by Grigni and Sipser.
The expressive power of the shuffle product
2010
International audience; There is an increasing interest in the shuffle product on formal languages, mainly because it is a standard tool for modeling process algebras. It still remains a mysterious operation on regular languages.Antonio Restivo proposed as a challenge to characterize the smallest class of languages containing the singletons and closed under Boolean operations, product and shuffle. This problem is still widely open, but we present some partial results on it. We also study some other smaller classes, including the smallest class containing the languages composed of a single word of length 2 which is closed under Boolean operations and shuffle by a letter (resp. shuffle by a l…
Stochastic Stability Analysis for Markovian Jump Neutral Nonlinear Systems
2012
In this paper, the stability problem is studied for a class of Markovian jump neutral nonlinear systems with time-varying delay. By Lyapunov-Krasovskii function approach, a novel mean-square exponential stability criterion is derived for the situations that the system's transition rates are completely accessible, partially accessible and non-accessible, respectively. Moreover, the developed stability criterion is extended to the systems with different bounded sector nonlinear constraints. Finally, some numerical examples are provided to illustrate the effectiveness of the proposed methods.
Filtering design for two-dimensional Markovian jump systems with state-delays and deficient mode information
2014
This paper is concerned with the problem of H"~ filtering for a class of two-dimensional Markovian jump linear systems described by the Fornasini-Marchesini local state-space model. The systems under consideration are subject to state-delays and deficient mode information in the Markov chain. The description of deficient mode information is comprehensive that simultaneously includes the exactly known, partially unknown and uncertain transition probabilities. By invoking the properties of the transition probability matrix, together with the convexification of uncertain domains, a new H"~ performance analysis criterion for the filtering error system is firstly derived. Then, via some matrix i…
Impact of chaotic dynamics on the performance of metaheuristic optimization algorithms : An experimental analysis
2022
Random mechanisms including mutations are an internal part of evolutionary algorithms, which are based on the fundamental ideas of Darwin's theory of evolution as well as Mendel's theory of genetic heritage. In this paper, we debate whether pseudo-random processes are needed for evolutionary algorithms or whether deterministic chaos, which is not a random process, can be suitably used instead. Specifically, we compare the performance of 10 evolutionary algorithms driven by chaotic dynamics and pseudo-random number generators using chaotic processes as a comparative study. In this study, the logistic equation is employed for generating periodical sequences of different lengths, which are use…