Search results for "Computer Science Applications"
showing 10 items of 3993 documents
In Search of Evidence for Model-Driven Development Claims: An Experiment on Quality, Effort, Productivity and Satisfaction
2015
Context: Model-Driven Development (MDD) is a paradigm that prescribes building conceptual models that abstractly represent the system and generating code from these models through transformation rules. The literature is rife with claims about the benefits of MDD, but they are hardly supported by evidences. Objective: This experimental investigation aims to verify some of the most cited benefits of MDD. Method: We run an experiment on a small set of classes using student subjects to compare the quality, effort, productivity and satisfaction of traditional development and MDD. The experiment participants built two web applications from scratch, one where the developers implement the code by h…
The harp: a vehicle crash test apparatus for full-scale crash test experiments
2012
Published version of an article in the journal: The International Journal of Advanced Manufacturing Technology. Also available from the publisher at: http://dx.doi.org/10.1007/s00170-012-3960-3 The current paper describes an apparatus for full-scale vehicle crash test experimentation. This apparatus is referred to as the harp. In brief, the harp may either accelerate a trolley which is impacted into a test vehicle or the test vehicle itself may be accelerated and impacted into an object such as a barrier, a pole, or another vehicle. If a trolley is accelerated, it is equipped with load cells to record the axial crushing force. If a test vehicle is accelerated, it is equipped with a three-ax…
An expert system hybrid architecture to support experiment management
2014
Specific expert systems are used for supporting, speeding-up and adding precision to in silico experimentation in many domains. In particular, many experimentalists exhibit a growing interest in workflow management systems for making a pipeline of experiments. Unfortunately, these type of systems does not integrate a systematic approach or a support component for the workflow composition/reuse. For this reason, in this paper we propose a knowledge-based hybrid architecture for designing expert systems that are able to support experiment management. This architecture defines a reference cognitive space and a proper ontology that describe the state of a problem by means of three different per…
Fifth Generation Networking Principles for a Service Driven Future Internet Architecture
2010
Published version of an article published in Wireless Personal Communications, vol. 57:393-411. Also available from the publisher at: http://dx.doi.org/10.1007/s11277-010-0076-7 The vision of all-IP networks where IP forms the simple common layer understandable across the whole network has undeniable advantages. However, such simplicity comes as a major hurdle to flexibility and functionality to the architecture. This is evident from the increasingly numerous and complex engineering solutions and optimizations required to accommodate essential qualities like mobility, security, realtime communication support etc or to mitigate the shortcomings inherent in the 'traditional Internet' architec…
Collaborative innovation: the decade that radically changed drilling performance
2012
This article sheds light on key factors associated with innovations that are mainly based on experiential learning. The history of a company engaged in the offshore oil and gas industry exemplifies the points: Hitec started out as a small company with limited financial resources, but over a 10-year period, its innovations and improvements radically transformed offshore oil and gas drilling operations. An evolutionary methodological approach is balanced by theoretically informed analysis. A main finding is that customer–supplier interaction was crucial. Hitec's success, crowned by its eventual acquisition by American capital, can be attributed in part to the know-how and technology provided …
Nonlinear extended thermodynamics of a dilute nonviscous gas
2002
This paper deals with further developments of a nonlinear theory for a nonviscous gas in the presence of heat flux, which has been proposed in previous papers, using extended thermodynamics. The fundamental fields used are the density, the velocity, the internal energy density, and the heat flux. Using the Liu procedure, the constitutive theory is built up without approximations and the consistence of the model is showed: it is shown that the model is determined by the choice of three scalar functions which must satisfy a system of partial differential equations, which always has solutions. Different changes of field variables are carried out, using different Legendre transformations, passi…
Metabolic and Vascular Effect of the Mediterranean Diet
2019
Several studies indicated how dietary patterns that were obtained from nutritional cluster analysis can predict disease risk or mortality. Low-grade chronic inflammation represents a background pathogenetic mechanism linking metabolic risk factors to increased risk of chronic degenerative diseases. A Mediterranean diet (MeDi) style has been reported as associated with a lower degree of inflammation biomarkers and with a protective role on cardiovascular and cerebrovascular events. There is heterogeneity in defining the MedDiet, and it can, owing to its complexity, be considered as an exposome with thousands of nutrients and phytochemicals. Recently, it has been reported a novel positive ass…
To Be or Not to Be a Germ Cell: The Extragonadal Germ Cell Tumor Paradigm
2021
In the human embryo, the genetic program that orchestrates germ cell specification involves the activation of epigenetic and transcriptional mechanisms that make the germline a unique cell population continuously poised between germness and pluripotency. Germ cell tumors, neoplasias originating from fetal or neonatal germ cells, maintain such dichotomy and can adopt either pluripotent features (embryonal carcinomas) or germness features (seminomas) with a wide range of phenotypes in between these histotypes. Here, we review the basic concepts of cell specification, migration and gonadal colonization of human primordial germ cells (hPGCs) highlighting the analogies of transcriptional/epigene…
Epigenomic k-mer dictionaries: shedding light on how sequence composition influences in vivo nucleosome positioning
2014
Abstract Motivation: Information-theoretic and compositional analysis of biological sequences, in terms of k-mer dictionaries, has a well established role in genomic and proteomic studies. Much less so in epigenomics, although the role of k-mers in chromatin organization and nucleosome positioning is particularly relevant. Fundamental questions concerning the informational content and compositional structure of nucleosome favouring and disfavoring sequences with respect to their basic building blocks still remain open. Results: We present the first analysis on the role of k-mers in the composition of nucleosome enriched and depleted genomic regions (NER and NDR for short) that is: (i) exhau…
The Binomial “Inflammation-Epigenetics” in Breast Cancer Progression and Bone Metastasis: IL-1β Actions Are Influenced by TET Inhibitor in MCF-7 Cell…
2022
The existence of a tight relationship between inflammation and epigenetics that in primary breast tumor cells can lead to tumor progression and the formation of bone metastases was investigated. It was highlighted how the induction of tumor progression and bone metastasis by Interleukin-1 beta, in a non-metastatic breast cancer cell line, MCF-7, was dependent on the de-methylating actions of ten-eleven translocation proteins (TETs). In fact, the inhibition of their activity by the Bobcat339 molecule, an inhibitor of TET enzymes, determined on the one hand, the modulation of the epithelial-mesenchymal transition process, and on the other hand, the reduction in the expression of markers of bo…